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您的检索式：作者名="Qianglong Han"
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| 1 | A hierarchical vascularized engineered bone inspired by intramembranous ossification for mandibular regeneration显示文摘Mandibular defects caused by injuries,tumors,and infections are common and can severely affect mandibular function and the patient's appearance.However,mandible reconstruction with a mandibular bionic structure remains challenging.Inspired by the process of intramembranous ossification in mandibular development,a hierarchical vascularized engineered bone consisting of angiogenesis and osteogenesis modules has been produced.Moreover,the hierarchical vascular network and bone structure generated by these hierarchical vascularized engineered bone modules match the particular anatomical structure of the mandible.The ultra-tough polyion complex has been used as the basic scaffold for hierarchical vascularized engineered bone for ensuring better reconstruction of mandible function.According to the results of in vivo experiments,the bone regenerated using hierarchical vascularized engineered bone is similar to the natural mandibular bone in terms of morphology and genomics.The sonic hedgehog signaling pathway is specifically activated in hierarchical vascularized engineered bone,indicating that the new bone in hierarchical vascularized engineered bone underwent a process of intramembranous ossification identical to that of mandible development.Thus,hierarchical vascularized engineered bone has a high potential for clinical application in mandibular defect reconstruction.Moreover,the concept based on developmental processes and bionic structures provides an effective strategy for tissue regeneration. | Xin Ye Jianxiang He Shaolong Wang Qianglong Han Dongqi You Bin Feng Feiya Zhao Jun Yin Mengfei Yu Huiming Wang Huayong Yang | 2022 | International Journal of Oral Science2022，14，3： | 1 |
| 2 | 2D Minimum Compliance Topology Optimization Based on a Region Partitioning Strategy显示文摘This paper presents an extended sequential element rejection and admission(SERA)topology optimizationmethod with a region partitioning strategy.Based on the partitioning of a design domain into solid regions and weak regions,the proposed optimizationmethod sequentially implements finite element analysis(FEA)in these regions.After standard FEA in the solid regions,the boundary displacement of the weak regions is constrained using the numerical solution of the solid regions as Dirichlet boundary conditions.This treatment can alleviate the negative effect of the material interpolation model of the topology optimization method in the weak regions,such as the condition number of the structural global stiffness matrix.For optimization,in which the forward problem requires nonlinear structural analysis,a linear solver can be applied in weak regions to avoid numerical singularities caused by the over-deformedmesh.To enhance the robustness of the proposedmethod,the nonmanifold point and island are identified and handled separately.The performance of the proposed method is verified by three 2D minimum compliance examples. | Chong Wang Tongxing Zuo Haitao Han Qianglong Wang Han Zhang Zhenyu Liu | 2023 | Computer Modeling in Engineering & Sciences2023，，7： | 0 |
| 3 | Numerical simulation and printability analysis of fused deposition modeling with dual-temperature control显示文摘Ideal tissue engineering scaffolds need interconnected pores and high porosity to enable cell survival,migration,proliferation,and differentiation.However,obtaining a high-resolution structure is difficult with traditional one-temperature control fused deposition modeling(FDM).In this study,we propose a dual-temperature control method to improve printability.A numerical model is developed in which the viscosity is a function of temperature and shear rate to study the influence of two different temperature control modes.Quantitative tests are used to assess filament formation and shape fidelity,including one-dimensional filament printing,deposition at corners,fusion,and collapse.By using dual-temperature control,the width of the deposited poly(ε-caprolactone)filament is reduced to 50μm.The comparative results of both the experimental method and numerical simulation suggest that the dual-temperature control FDM can manufacture spatially arranged constructs and presents a promising application in tissue engineering。 | Xiaodan Huo Bin Zhang Qianglong Han Yong Huang Jun Yin | 2023 | Bio-Design and Manufacturing2023，6，2： | 0 |
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