|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ABNORMAL FLOWER AND GRAIN 1 encodes OsMADS6 and determines palea identity and affects rice grain yield and quality显示文摘The palea and lemma are floral organ structures unique to grasses;these structures form the hull and directly affect grain size and quality. However, the molecular mechanisms controlling the development of the hull are not well understood. In this study, we characterized the rice(Oryza sativa) abnormal flower and grain1(afg1) mutant, a new allele of OsMADS6. Similar to previously characterized osmads6 alleles, in the afg1 floret, the palea lost its marginal region and acquired the lemma identity. However, in contrast to other osmads6 alleles, the afg1 mutant showed altered grain size and grain quality, with decreased total starch and amylose contents, and increased protein and soluble sugar contents. The analysis of transcriptional activity suggested that AFG1 is a transcriptional activator and may affect grain size by regulating the expression levels of several genes related to cell expansion and proliferation in the afg1 mutant. These results revealed that AFG1 plays an important role in determining palea identity and affecting grain yield and quality in rice. | Xiaoqi Yu Saisai Xia Qiankun Xu Yuanjiang Cui Ming Gong Dali Zeng Qiang Zhang Lan Shen Guiai Jiao Zhenyu Gao Jiang Hu Guangheng Zhang Li Zhu Longbiao Guo Deyong Ren Qian Qian | 2020 | Science China(Life Sciences)2020，63，2： | 10 |
| 2 | Mussel-inspired agarose hydrogel scaffolds for skin tissue engineering显示文摘Polysaccharide hydrogels are widely used in tissue engineering because of their superior biocompatibility and low immunogenicity.However,many of these hydrogels are unrealistic for practical applications as the cost of raw materials is high,and the fabrication steps are tedious.This study focuses on the facile fabrication and optimization of agarose-polydopamine hydrogel(APG)scaffolds for skin wound healing.The first study objective was to evaluate the effects of polydopamine(PDA)on the mechanical properties,water holding capacity and cell adhesiveness of APG.We observed that APG showed decreased rigidity and increased water content with the addition of PDA.Most importantly,decreased rigidity translated into significant increase in cell adhesiveness.Next,the slow biodegradability and high biocompatibility of APG with the highest PDA content(APG3)was confirmed.In addition,APG3 promoted full-thickness skin defect healing by accelerating collagen deposition and promoting angiogenesis.Altogether,we have developed a straightforward and efficient strategy to construct functional APG scaffold for skin tissue engineering,which has translation potentials in clinical practice. | Ting Su Mengying Zhang Qiankun Zeng Wenhao Pan Yijing Huang Yuna Qian Wei Dong Xiaoliang Qi Jianliang Shen | 2021 | Bioactive Materials2021，6，3： | 6 |
| 3 | The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice显示文摘Moderate plant height and successful establishment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study,we characterized a rice gene, ABNORMAL FLOWER AND DWARF1(AFD1) that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull-like lodicules.AFD1 encoded a DUF640 domain protein and was expressed in all tested tissues and organs. Subcellular localization showed AFD1-green fluorescent fusion protein(GFP) was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes. | Deyong Ren Yuchun Rao Liwen Wu Qiankun Xu Zizhuang Li Haiping Yu Yu Zhang Yujia Leng Jiang Hu Li Zhu Zhenyu Gao Guojun Dong Guangheng Zhang Longbiao Guo Dali Zeng Qian Qian | 2016 | Journal of Integrative Plant Biology2016，58，6： | 4 |
| 4 | Ductile and ultrahigh-strength eutectic high-entropy alloys by large-volume 3D printing显示文摘1.Introduction Additive manufacturing or 3D printing outweighs conventional casting methods in the aspect of complex parts fabrication,which can realize one-step formation without the need of complicated cast dies.3D printing significantly promotes industrial production for making near-net shaped components.However,this promising technique is not always ideally applicable for metals and alloys.For example,titanium alloys prepared by 3D printing often suf-fer from poor plasticity,and usually require further complex heat treatment or hot isostatic pressing treatment,in order to remove internal stress and regulate plasticity and strength[1,2],which de-feats the original intention of employing additive manufacturing.One of the fundamental causes for such issues is the low fluidity of the alloys upon melting,leading to great chemical heterogeneity,high porosity content and residual stresses.This limitation hinders further design and fabrication of high-performance printable alloys from large scale production and application. | Yiping Lu Xiaoxiang Wu Zhenghong Fu Qiankun Yang Yong Zhang Qiming Liu Tianxin Li Yanzhong Tian Hua Tan Zhiming Li Tongmin Wang Tingju Li | 2022 | Journal of Materials Science & Technology2022，，31： | 4 |
| 5 | Nitrogen doped tin oxide nanostructured catalysts for selective electrochemical reduction of carbon dioxide to formate显示文摘Tin/tin oxide materials are key electrocatalysts for selective conversion of CO_2 to formate/formic acid.Herein we report a tin oxide material with nitrogen doping by using ammonia treatment at elevated temperature. The N doped material demonstrated enhanced electrocatalytic CO_2 reduction activity, showing high Faradaic efficiency(90%) for formate at -0.65 V vs. RHE with partial current density of 4 mA/cm^2.The catalysis was contributed to increased electron negativity of N atom compared to O atom. Additionally, the N-doped catalyst demonstrates sulfur tolerance with retained formate selectivity. The analysis after electrolysis shows that the catalyst structure partially converts to metallic Sn, and thus the combined Sn/N-SnO_2 is the key for the active CO_2 catalysis. | Qiankun Li Zhuo Wang Miao Zhang Pengfei Hou Peng Kang | 2017 | Journal of Energy Chemistry2017，26，5： | 3 |
| 6 | A fiber Bragg grating based earth and water pressures transducer with three-dimensional fused deposition modeling for soil mass显示文摘A novel fiber Bragg grating(FBG)sensor with three-dimensional(3D)fused deposition modeling(FDM)approach is proposed for effective stress measurement in soil mass.The three-diaphragm structure design is developed to measure earth and water pressures simultaneously.The proposed transducer has advantages of small size,high sensitivity,low cost,immunity to electromagnetic interference and rapid prototyping.The working principle,design parameters,and manufacturing details are discussed.The proposed transducer was calibrated for earth and water pressures measurement by using weights and a specially designed pressure chamber,respectively.The calibration results showed that the wavelength of the transducer was proportional to the applied pressure.The sensitivity coefficients of the earth and water pressures were 12.633 nm/MPa and 6.282 nm/MPa,respectively.Repeated tests and error analysis demonstrated the excellent stability and accuracy of the earth and water pressure measurements.The performance of the proposed transducer was further verified by a model experimental test and numerical analysis,which indicated that the proposed transducer has great potential for practical applications. | Yue Qin Qiankun Wang Dongsheng Xu Jiaming Yan Shanshan Zhang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 3 |
| 7 | Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice显示文摘Advanced maternal age is characterized by declines in the quantity and quality of oocytes in the ovaries,and the aging process is accompanied by changes in gut microbiota composition.However,little is known about the relationship between gut microbiota and ovarian aging.By using fecal microbiota transplantation(FMT)to transplant material from young(5-week-old)into aged(42-week-old)mice,we find that the composition of gut microbiota in FMT-treated mice presents a“younger-like phenotype”and an increase of commensal bacteria,such as Bifidobacterium and Ruminococcaceae.Moreover,the FMT-treated mice show increased anti-inflammatory cytokine IL-4 and decreased pro-inflammatory cytokine IFN-γ.Fertility tests for assessing ovarian function reveal that the first litter size of female FMT-treated mice is significantly higher than that of the non-FMT group.Morphology analysis demonstrates a dramatic decrease in follicle atresia and apoptosis as well as an increase in cellular proliferation in the ovaries of the FMT-treated mice.Our results also show that FMT improves the immune microenvironment in aged ovaries,with decreased macrophages and macrophage-derived multinucleated giant cells(MNGCs).These results suggest that FMT from young donors could be a good choice for delaying ovarian aging. | Li Xu Qiankun Zhang Xiaowei Dou Yipeng Wang Jianwei Wang Yong Zhou Xingyin Liu Jing Li | 2022 | Journal of Genetics and Genomics2022，49，11： | 2 |
| 8 | A High-Performance Composite Epoxy Coating Based on the Cooperative Enhancement of 2D Co_(2)(OH)2BDC and Electrospun PAN Nanofiber Membrane显示文摘Based on a two-dimensional(2D)Co-MOF(Co_(2)(OH)_(2)BDC)with a self-contained organic interface and low conductivity,a composite epoxy coating(2D Co_(2)(OH)_(2)BDC-PAN/EP)was constructed by a two-step preparation.First,a polyacrylonitrile(PAN)nanofiber membrane was electrospuned on the surface of Q235 steel,followed by coating using the epoxy coating(EP)containing 2D Co_(2)(OH)_(2)BDC.The 2D Co_(2)(OH)_(2)BDC-PAN/EP composite epoxy coatings showed robust mechanical performance and excellent corrosion resistance capacity. | Zhao Huarong Zhang Yueshuang Gan Shaojie Yue Qiankun Liu Zan Cheng Zhilin | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 2 |
| 9 | Rapid microwave-assisted synthesis of graphene nanosheet/Co 3 O 4 composite for supercapacitors显示文摘 | Jun Yan Tong Wei Wenming Qiao Bo Shao Qiankun Zhao Lijun Zhang Zhuangjun Fan | 2010 | Electrochimica Acta2010，，： | 2 |
| 10 | Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs显示文摘Ammonia,a common toxic gas,is not only one of the main causes of haze,but also can enter respiratory tract and directly affect the health of humans and animals.Pig was used as an animal model for exploring the molecular mechanism and dose effect of ammonia toxicity to lung.In this study,the apoptosis of type II alveolar epithelial cells was observed in high ammonia exposure group using transmission electron microscopy.Gene and protein expression analysis using transcriptome sequencing and western blot showed that low ammonia exposure induced T-cell-involved proinflammatory response,but high ammonia exposure repressed the expression of DNA repair-related genes and affected ion transport.Moreover,high ammonia exposure significantly increased 8-hydroxy-2-deoxyguanosine (8-OHdG) level,meaning DNA oxidative damage occurred.In addition,both low and high ammonia exposure caused oxidative stress in pig lungs.Integrated analysis of transcriptome and metabolome revealed that the up-regulation of LDHB and ND2 took part in high ammonia exposure-affected pyruvate metabolism and oxidative phosphorylation progress,respectively.Inclusion,oxidative stress mediated ammonia-induced proinflammatory response and apoptosis of porcine lungs.These findings may provide new insights for understanding the ammonia toxicity to workers in livestock farms and chemical fertilizer plants. | Daojie Li Long Shen Di Zhang Xiaotong Wang Qiankun Wang Wenhao Qin Yun Gao Xiaoping Li | 2023 | Journal of Environmental Sciences2023，，4： | 2 |
| 11 | MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1显示文摘Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious strategies.Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment.Here,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound healing.Silk fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were constructed.The designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac protein.Gluc signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of SGM-Exo.Moreover,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in miR146a-Exos.Superior to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and neovascularization.The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment.Here,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering. | Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang Jianlong Su Mengli Sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 12 | Global exponential stability of impulsive Cohen Grossberg neural network with time-varying delays显示文摘 | SONG Qiankun ZHANg Jiye | 2008 | Nonlinear Analysis: Real World Applications2008，9，2： | 1 |
| 13 | Ameliorative effect of scutellarin on acute alcohol brain injury in mice显示文摘Drinking culture has high significance in both China and the world,whether in the entertainment sector or in social occasions;according to the World Health Organization's 2018 Global Alcohol and Health Report,about 3 million people died from excessive drinking in 2016,accounting for 5.3%of the total global deaths that year.Oxidative stress and inflammation are the most common pathological phenomena caused by alcohol abuse(Snyder et al.,2017). | Tianmeng ZHANG Kun WANG Hui FAN Qiankun YANG Xiao ZHANG Feixue LIU Xin FENG Yi CHEN Daoyang TENG Panpan ZHAO Jingquan DONG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 1 |
| 14 | In vitro myogenic and adipogenic differentiation model of genetically engineered bovine embryonic fibroblast cell lines显示文摘 | Jinlong Yin Xun Jin Samuel Beck Dong Ho Kang Zhongshan Hong Zhehu Li Yongcheng Jin Qiankun Zhang Yun-Jaie Choi Sung-Chan Kim Hyunggee Kim | 2010 | Biotechnology Letters2010，，2： | 1 |
| 15 | Fabrication of tungsten carbide–vanadium carbide core–shell structure powders and their application as an inhibitor for the sintering of cemented carbides显示文摘 | Nan Lin Yuehui He Chonghu Wu Qiankun Zhang Jin Zou Zhongwei Zhao | 2012 | Scripta Materialia2012，，10： | 1 |
| 16 | Global exponential stability of impulsive Cohen-Grossberg neural network with time- varying delays 显示文摘 | SONG Qiankun ZHANG Jiye | 2008 | Nonlinear Analysis: Real World Applications2008，9，2： | 1 |
| 17 | Global exponential stability of impulsive Cohen Grossberg neural network with time-varying delays显示文摘 | SONG Qiankun ZHANG Jiye | 2008 | Nonlinear Analysis:Real World Applications2008，9，2： | 1 |
| 18 | Cordierite Ceramics Prepared from Poor Quality Kaolin for Electric Heater Supports: Sintering Process, Phase Transformation, Microstructure Evolution and Properties显示文摘To efficiently utilize the kaolin, an economical way of preparing cordierite ceramic with high performance for electric heater supports was put forward. In this study, sintering process, phase transformation, microstructure evolutions were systematically studied by heating microscope, X-ray diffraction, scanning electronic microscope and thermal analysis. Properties(physical properties, electrical properties and coefficient of thermal expansion(CTE)) were tested for comprehensive performance evaluation. The results showed that the utilization of poor quality kaolin broadened the firing range of cordierite ceramic which was from 1 200 to 1 380 ℃. Microstructure becomes loose with increasing of the pore size, which had significant influence on bending strength and electrical properties. High content of K2 O in poor quality kaolin was the reason for liquid phase generation in sintering process, which further leads to microstructural changes. The cordierite ceramic sintered at 1 320 ℃ had the properties as follows: CTE of 1.98×10^(-6) ℃^(-1)(500 ℃), bending strength of 90 MPa, apparent porosity of 15.1%, dielectric constant of 7.5(100 Hz), and volume resistivity of 1.05×109 Ω·cm(100 Hz). The comprehensive properties are very suitable for use as electric heater supports. | 吴建锋 陆成龙 XU Xiaohong ZHANG Yaxiang WANG Dongbin ZHANG Qiankun | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，3： | 1 |
| 19 | Rapid microwave-assisted synthesis of graphene nanosheet/Co 3 O 4 composite for supercapacitors显示文摘 | Jun Yan Tong Wei Wenming Qiao Bo Shao Qiankun Zhao Lijun Zhang Zhuangjun Fan | 2010 | Electrochimica Acta2010，，23： | 1 |
| 20 | Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT,p38 MAPK/NF-κB pathways显示文摘Alcoholic liver disease(ALD)is the most frequent liver disease worldwide,resulting in severe harm to personal health and posing a serious burden to public health.Based on the reported antioxidant and anti-inflammatory capacities of scutellarin(SCU),this study investigated its protective role in male BALB/c mice with acute alcoholic liver injury after oral administration(10,25,and 50 mg/kg).The results indicated that SCU could lessen serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels and improve the histopathological changes in acute alcoholic liver;it reduced alcohol-induced malondialdehyde(MDA)content and increased glutathione peroxidase(GSH-Px),catalase(CAT),and superoxide dismutase(SOD)activity.Furthermore,SCU decreased tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and IL-1βmessenger RNA(mRNA)expression levels,weakened inducible nitric oxide synthase(iNOS)activity,and inhibited nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome activation.Mechanistically,SCU suppressed cytochrome P450 family 2 subfamily E member 1(CYP2E1)upregulation triggered by alcohol,increased the expression of oxidative stress-related nuclear factor erythroid 2-related factor 2(Nrf2)and heme oxygenase-1(HO-1)pathways,and suppressed the inflammation-related degradation of inhibitor of nuclear factor-κB(NF-κB)-α(IκBα)as well as activation of NF-κB by mediating the protein kinase B(AKT)and p38 mitogen-activated protein kinase(MAPK)pathways.These findings demonstrate that SCU protects against acute alcoholic liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and suppressing inflammation by regulating the AKT,p38 MAPK/NF-κB pathways. | Xiao ZHANG Zhicheng DONG Hui FAN Qiankun YANG Guili YU Enzhuang PAN Nana HE Xueqing LI Panpan ZHAO Mian FU Jingquan DONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员