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| 1 | Genomic Sequencing and Molecular Characteristics of A Very Virulent Strain of Infectious Bursal Disease Virus Isolated in China显示文摘 | QI X L GA L QIN L T | | 0，，12： | 1 |
| 2 | No relation between ACE-I/D polymorphism and high altitude pulmonary edema in the Han Chinese显示文摘Objectives To explore whether the angiotensin Ι-converting enzyme(ACE) I/D(insertion/deletion) polymorphism is associated with the susceptibility to high altitude pulmonary edema(HAPE) in the Han Chinese. Methods One hundred and forty-seven HAPE-p(HAPE patients) and 193 HAPE-r(HAPE resistants) were enrolled from the Yushu earthquake reconstruction workers in Qinghai province where the altitude is over 3 500 m above sea level. Blood samples were collected from each of the HAPE-p and HAPE-r groups. Information about physiological phenotypes was obtained via fieldwork investigation. The ACE-I/D polymorphism in HAPE-p and HAPE-r was detected by polymerase chain reaction(PCR). Results The SaO2 was significantly lower while HR was significant1y higher in HAPE-p group than those in HAPE-r group. The genotype frequencies of ACE-I/D for II, ID, DD in HAPE-r and HAPE-p groups were 0.430, 0.446, 0.124 and 0.435, 0.469, 0.095, respectively, the allelic frequencies of I and D were 0.650, 0.350 and 0.670, 0.330, respectively. The OR of ID, DD and D alleles relative to II for HAPE was 0.961(0.610~1.514), 1.322(0.634~2.758) and 1.080(0.783~1.489). There was no significant difference of the genotypic and the allelic frequencies in ACE-I/D polymorphism between HAPE-p and HAPE-r groups. Conclusions There is no relation between ACE-I/D polymorphism and HAPE in the Han Chinese. | Ying-zhong YANG Ya-ping WANG Wei GUAN Yang DU Qin GA Ri-li GE | 2013 | 中国应用生理学杂志2013，29，6： | 1 |
| 3 | Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus 显示文摘 | Xu H Qin S Carrasco GA | 2009 | Neuroscience2009，158，： | 1 |
| 4 | Synthesis and properties of binaphthyl chiral thermally activated delayed fluorescence molecules using thioxanthone as acceptor显示文摘The currently reported axial chiral molecules based on the 3,3'-substitution of the binaphthyl skeleton are limited by intrinsic fluorescence properties,resulting in generally low device efficiencies(EQE<5%)of related organic light emitting diodes(OLEDs).Herein,we designed and synthesized four pair of chiral binaphthyl enantiomers(R/S-1-R/S-4)adopting acceptor-donor-donor-acceptor(ADDA)structure by introducing different thioxanthone modification groups on the 3,3'-position of 2,2'-dimethoxy-1,1'-binaphthalene.Among them,emitter R/S-2 and R/S-4 obtained by enhancing intramolecular charge transfer exhibited TADF characteristics due to relatively small Est of 0.12eV and 0.17eV,and relatively moderate SOC matrix elements of 0.28 cm^(-1)and 0.10 cm^(-1)between the 1CT and 3LE states.The CD spectra of these enantiomers in diluted solutions showed perfect mirror images and reasonable gabs for small organic molecules(10^(-4)-10^(-3)).And the external quantum eficiencies(EQE)of 10.9%and 8.32%for device A and B based on emitter S-2 and S-4 were highest compared with currently reported axial chiral molecules based on the 3,3'-position substitution of binaphthyl skeleton,providing simple molecular design strategies to construct efficient CP-OLED device. | Xiangyu Dong Shaogang Shen Yuanyuan Qin Xiaoxiao Hu Honglei Gao Guanhao Liu Teng Ga Zhi Pang Pengfei Wang Ying Wang | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 5 | Energy power in mountains:difference in metabolism pattern results in different adaption traits in Tibetans显示文摘Energy metabolism plays an important role in life survival for species living in high altitude hypoxia condition.Air-breathing organisms require oxygen to create energy.Tibetans are the well-adapted highlanders in Qinghai-Tibetan Plateau.It was thought that different metabolic approaches could lead to different adaptation traits to high altitude hypoxia.Recently identified hypoxia inducible factors pathway regulators,endothelial PAS domain protein1(EPAS1)/HIF-2α and PPARA,were involved in decreasing hemoglobin concentrations in Tibetans.Because EPAS1 and PPARA also modulated the energy metabolism during hypoxia,we hypothesized that positive selected EPAS1 and PPARA genes were also involved in unique energy metabolisms in Tibetans.In this brief review,we take a look into genetic determinations to energy metabolisms for hypoxia adaptations traits in Tibetans and mal-adaptive conditions such as high altitude diseases. | Zhen-zhong BAI Guo-en JIN Tana WU-REN Qin GA Ri-li GE | 2012 | 中国应用生理学杂志2012，28，6： | 0 |
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