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| 1 | Current status of severe acute respiratory syndrome in China显示文摘Severe acute respiratory syndrome (SARS), also called infectious atypical pneumonia, is an emerging infectious disease caused by a novel variant of coronavirus (SARS associated coronavirus, SARS-CoV). It is mainly characterized by pulmonary infection with a high infectivity and fatality.SARS is swept across almost all the continents of the globe, and has currently involved 33 countries and regions, including the China's Mainland, Hong Kong, Taiwan, North America and Europe. On June 30, 2003, an acumulative total reached 8450 cases with 810 deaths. SARS epidemic was very rampant in March, April and May 2003 in the mainland of China and Hong Kong. Chinese scientists and healthcare workers cooperated closely with other scientists from all over the world to fight the disease. On April 16, 2003, World Health Organization (WHO) formally declared that SARSCoV was an etiological agent of SARS. Currently, there is no specific and effective therapy and prevention method for SARS. The main treatments include corticosteroid therapy,antiviralagents, anti-infection, mechanical ventilation and isolation. This disease can be prevented and controlled, and it is also curable. Under the endeavor of the Chinese Government, medical staffs and other related professionals,SARS has been under control in China, and Chinese scientists have also made a great contribution to SARS research.Otherstudies in developing new detection assays and therapies, and discovering new drugs and vaccines are in progress. In this paper, we briefly review the current status of SARS in China. | Qing-HeNie Xin-DongLuo ]ian-ZhongZhang QinSu | 2003 | World Journal of Gastroenterology2003，9，8： | 14 |
| 2 | Laminin induces the expression of cytokeratin 19 in hepatocellular carcinoma cells growing in culture显示文摘AIM: To study the abnormal cytokeratin (CK) expression,emergence of CK19 with or without CK7, in liver parenchymal cells and the role of laminin (LN), a basement membrane protein, in this process.METHODS: Six hepatocellular carcinoma (HCC) cell lines were examined for different CKs, LN and its receptor by immunocytochemistry and Western blotting. Double immunofluorescent reaction, laser-scanning confocal microscopy and an in vitro induction procedure were used to demonstrate the role of LN in regulating CK19 expression in these cells.RESULTS: Immunoreactivities for CK8, CK18, CK7 and the receptor for LN were observed in all the six HCC cell lines examined. However, CK19 was merely found in four of the six cell lines, and was in any case associated with LN expression. Laser-scanning confocal microscopydemonstrated the concomitant presence of these two molecules in most of the positive cells. In the two HCC cell lines, originally negative for CK19, addition of LN to the culture medium resulted in an induction of CK19 in a dosedependent manner. Both the artificially induced and the intrinsic production of CK19 were completely blocked by an antibody to LN.CONCLUSION: LN can induce expression of CK19 in HCC cells in vitro, providing direct evidence for our hypothesis that the abnormal hepatocytic CK19 expression in situ is due to pathologic LN deposition. | QinSu YongFu Yan-FangLiu WeiZhang JieLiu Chun-MeiWang | 2003 | World Journal of Gastroenterology2003，9，5： | 5 |
| 3 | Towards a higher international standard-World Journal of Gastroenterology will be published semimonthly in 2004显示文摘World Journal of Gastroenterology (WJG) is an international academic journal in digestology published in China. The WJG was established in 1995 under the name of China National Journal of New Gastroenterology, and adapted its present title in 1998. The WJG (ISSN 1007-9327), now published monthlyby the WJG Press, is a 210×297 mm-sized journal with 256pages in each issue. The Journal is distributed by the | Lian-ShengMa Bo-RongPan Jing-YunMa Jia-YuXu Xie-NingWu Xian-Lin.wang Han-MingLu HarryHua-XiangXia Hong-XiangLiu Jian-ZhongZhang Qinsu Shi-YanRen LiZhu Li-HongZhu You-YongLu | 2004 | World Journal of Gastroenterology2004，10，1： | 1 |
| 4 | Clonality of nodular lesions in liver cirrhosis and chromosomal abnormalities in monoclonal nodules of altered hepatocytes显示文摘 | LiGong Yan‐HongLi QinSu XiaChu WeiZhang | 2010 | Histopathology2010，，5： | 1 |
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