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| 1 | c-Jun, at the crossroad of the signaling network显示文摘c-Jun,the most extensively studied protein of the activator protein-1(AP-1)complex,is involved in numerous cell activities,such as proliferation,apoptosis,survival,tumorigenesis and tissue morphogenesis.Earlier studies focused on the structure and function have led to the identification of c-Jun as a basic leucine zipper(bZIP)transcription factor that acts as homo-or heterodimer,binding to DNA and regulating gene transcription.Later on,it was shown that extracellular signals can induce post-translational modifications of c-Jun,resulting in altered transcriptional activity and target gene expression.More recent work has uncovered multiple layers of a complex regulatory scheme in which c-Jun is able to crosstalk,amplify and integrate different signals for tissue development and disease.One example of such scheme is the autocrine amplification loop,in which signal-induced AP-1 activates the c-Jun gene promoter,while increased c-Jun expression feedbacks to potentiate AP-1 activity.Another example of such scheme,based on recent characterization of gene knockout mice,is that c-Jun integrates signals of several developmental pathways,including EGFR-ERK,EGFR-RhoA-ROCK,and activin B-MAP3K1-JNK for embryonic eyelid closure.After more than two decades of extensive research,c-Jun remains at the center stage of a molecular network with mysterious functional properties,some of which are yet to be discovered.In this article,we will provide a brief historical overview of studies on c-Jun regulation and function,and use eyelid development as an example to illustrate the complexity of c-Jun crosstalking with signaling pathways. | Qinghang Meng Ying Xia | 2011 | Protein & Cell2011，2，11： | 32 |
| 2 | Loss of IKB kinase βpromotes myofibroblast transformation and senescence through activation of the ROS-TGFβ autocrine loop显示文摘 | Liang Chen Zhimin Peng Qinghang Meng Maureen Mongan Jingcai Wang Maureen Sartor Jing-Chen Liang Niu Mario Medvedovic Winston Kao Ying Xia | 2016 | Protein & Cell2016，7，5： | 4 |
| 3 | Unveiling annealing texture formation and static recrystallization kinetics of hot-rolled Mg-Al-Zn-Mn-Ca alloy显示文摘The development of Mg-Al-Zn-Mn-Ca series alloys provides a potential prospect to achieve high strength and formability at room temperature(RT).The formation of elliptical annular texture is treated as a crucial factor for the enhanced RT formability.However,the origin of such an elliptical annular texture formation has been rarely reported.Herein,we unveiled the formation and evolution of elliptical annular texture in the hot-rolled Mg-1.6 Al-0.8 Zn-0.4 Mn-0.5 Ca(AZMX1100,wt.%)alloy after annealing at different temperatures for 1 h,and its static recrystallization(SRX)kinetics in given annealing temperature for different time.The results revealed that the formation of elliptical annular texture in the hot-rolled AZMX1100 alloy after annealing was derived from nucleation-oriented SRX mechanism,which took place in 200-300°C,induced by cracked chain-shaped Al2 Ca phases,contraction twins,intersections of double twins,intersections of double twins and grain boundaries and non-basal slips.On further annealing from300-450°C,the grains with 45°–70°transverse direction(TD)preferentially grew,which made elliptical annular texture extended along the TD.Based on the Johnson-Mehl-Avrami-Kolmogorov(JMAK)model,Avrami exponent n value was estimated to be 0.68–1.02,attributed to non-random SRX nucleation,giving rise to the lower activation energy QRof nucleation of^74.24 k J/mol.Since the co-segregation of Al,Zn and Ca atoms in grain boundaries created a strong interaction of solutes and grain boundaries,the hot-rolled AZMX1100 alloy exhibited the higher activation energy Qg(~115.48 k J/mol)of grain growth. | Qinghang Wang Bin Jiang Aitao Tang Jie Fu Zhongtao Jiang Haoran Sheng Dingfei Zhang Guangsheng Huang Fusheng Pan | 2020 | Journal of Materials Science & Technology2020，36，8： | 3 |
| 4 | Novel Mg-Bi-Mn wrought alloys:The effects of extrusion temperature and Mn addition on their microstructures and mechanical properties显示文摘Designing and developing the Mg alloys with low cost and high performance is of the great significance.Novel Mg-1Bi-xMn(x=0,1and 2 wt.%)extruded alloys,in this work,were fabricated at different extrusion temperatures(220,250 and 300℃).The effects of extrusion temperature and Mn addition on the microstructures and mechanical properties of extruded alloys at room temperature were investigated.The results showed that decreasing the extrusion temperature could refine the average grain size,weaken the basal fiber texture intensity and improve the microstructural homogeneity of extruded alloys.When the Mn element was added to the Mg-1Bi alloy,the average grain size further reduced.Simultaneously,the number fraction of low angle grain boundaries(LAGBs)increased,along with the occurrence of regions without dynamic recrystallization(unDRX).The combined effects of grain refinement and coarse unDRXed structure made the textures of the extruded Mg-1Bi-xMn alloys never obviously change.Besides few large size un-dissolved second phases,fine Mg_(3)Bi_(2) and α-Mn phases were precipitated in the extruded Mg-1Bi-xMn alloys and partial nano-scaleα-Mn particles pined at grain boundaries(GBs)to effectively impede the migration of GBs for grain refinement.Microstructural variations determined the extruded Mg-1Bi-2Mn alloy to exhibit the highest yield strength of~319.2 MPa with the appropriate elongation-to-failure of~13%at the extrusion temperature of 220℃,and they enabled the extruded Mg-1Bi-1Mn alloy to show the highest elongation-to-failure of~26%without the obvious loss of yield strength of~252.1 MPa. | Qinghang Wang Haowei Zhai Lintao Liu Hongbo Xia Bin Jiang Jun Zhao Daolun Chen Fusheng Pan | 2022 | Journal of Magnesium and Alloys2022，10，9： | 2 |
| 5 | Grain size dependence of annealing strengthening of an extruded Mg-Gd-Zn alloy subjected to pre-compression deformation显示文摘In this work, pre-strain annealing strengthening(PSAS) effect was investigated in an extruded Mg-1.0Gd-1.5 Zn(wt.%) alloy with respect to different grain sizes. The evolution of microstructures was provided by scanning electron microscopy(SEM), electron backscattered diffraction(EBSD), transmission electron microscopy(TEM) and high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM) under the initial state, pre-compression, intermediate annealing and re-compression conditions. The obtained results showed a grain size-dependent PSAS effect in the alloy. The sample with larger grain sizes corresponded to a higher strengthening effect, which mainly resulted from a more remarkable hindrance for the growth of existing twins and a larger proportion of activation for the nucleation of new twins. This was closely associated with the increase of back stress and friction stress for twin boundary motion impeded by the larger restraint of dislocations, the higher stress field surrounding solutes and the more Zn segregation. In addition to twinning behavior, Guinier Preston(G.P.) zones on basaldislocations were found after intermediate annealing and provided an extra strengthening by inhibiting the motions of gilding pre-existing dislocations and newly formed ones, but it was independent on the grain size. | Qinghang Wang Siyuan Chen Bin Jiang Zhaoyang Jin Lingyu Zhao Junjie He Dingfei Zhang Guangsheng Huang Fusheng Pan | 2022 | Journal of Magnesium and Alloys2022，10，12： | 1 |
| 6 | Finite element analysis of moment-retation relationships for human cervical spine 显示文摘 | Zhang Qinghang Teo EC Ng H | 2004 | Journal of Biomechanics2004，39，： | 1 |
| 7 | Development and Validation of A CO-C7 FE Complex for Biomechanical Study 显示文摘 | Zhang Qinghang Teo EC Ng H | 2005 | Journal of Biomechanical Engineering2005，127，： | 1 |
| 8 | FE analysis of headneck responses during whiplash 显示文摘 | Teo EC Zhang Qinghang Lee PVS | 2004 | INFATS Proceedings2004，10，： | 1 |
| 9 | An effective approach called the composite extrusion to improve the mechanical properties of AZ31 magnesium alloy sheets显示文摘 | Fusheng Pan Qinghang Wang Bin Jiang Junjie He Yanfu Chai Jun Xu | 2016 | Materials Science & Engineering A2016，，： | 1 |
| 10 | Finite element analysis of moment-rotation relationships for human cervical spine 显示文摘 | Zhang Qinghang Teo EC Ng HW | 2006 | J Biomech2006，39，： | 1 |
| 11 | A no-vel biomaterial-Fe3 O 4:TiO 2 core-shell nanoparticle with magnetic performance and high visible lighttphotocatalytic activity显示文摘 | He Qinghang Zhang Zhenxi Xiong Jianwen | | 0，，： | 1 |
| 12 | Influence of Laminotomies and Laminectomies on Cervical Spine Biomechanics Under Combined Flexion-Extension显示文摘 | Ng HW Teo EC Zhang Qinghang | 2004 | Journal of Applied Biomechanics2004，20，： | 1 |
| 13 | Understanding the enhanced ductility of Mg-Gd with Ca and Zn microalloying by slip trace analysis显示文摘This research studied the mechanisms of Ca and Zn microalloying on the enhancement of ductility of extruded Mg-Gd sheet by combing electron backscattered diffraction and slip trace analysis.The ductility and microstructure of extruded Mg-0.6Gd and Mg-0.6Gd-0.3Ca-0.2Zn(wt%)sheets were investigated.Basal slip was the main deformation mode under investigation.Ca and Zn microalloying increased the frequency of grain boundaries(GBs)with misorientation angles(θs)<35°,promoted slip transfer across GBs and restricted the basal slip localization.In addition,there were a higher number of GB cracks homogeneously distributed in the Mg-0.6Gd sheet than in the Mg-0.6Gd-0.3Ca-0.2Zn sheet,attributed to the increased cohesion of GBs.The enhancement of basal slip,the suppression of slip localization and the suppression of GB cracking were contributed to the increased ductility for Mg-0.6Gd-0.3Ca-0.2Zn sheet. | Jun Zhao Bin Jiang Yuan Yuan Qinghang Wang Ming Yuan Aitao Tang Guangsheng Huang Dingfei Zhang Fusheng Pan | 2021 | Journal of Materials Science & Technology2021，，36： | 1 |
| 14 | Biomechanical effects of C2-C7 intersegmental stability due to laminectomy with unilateral and bilateral facetectomy显示文摘 | Ng HW Teo EC Zhang Qinghang | 2004 | Spine2004，29，16： | 1 |
| 15 | Finite element analysis of moment-rotation relationships for human cervical spine显示文摘 | Zhang Qinghang Teo EC Ng HW | 2006 | J Biomech2006，39，： | 1 |
| 16 | Finite element analysis of momentrotationrelationships for human cervical spine显示文摘 | Zhang Qinghang Teo EC Ng H | 2004 | Journal ofBiomechanics2004，39，1： | 1 |
| 17 | Development and Validation of A C0-C7FE Complex for Biomechanical Study显示文摘 | Zhang Qinghang Teo EC NgH | 2005 | Journal of BiomechanicalEngineering2005，127，10： | 1 |
| 18 | Inter- action Between NFrd3 and NFAT Coordinates Cardiac Hy- pertrophy and Pathological Remodeling 显示文摘 | Qinghang Liu Yi Chen Mannix Auger-Messier et a/ | 2012 | Circulation Re- search2012，110，： | 1 |
| 19 | 3D fluorescence spectral data interpolation by using IDW显示文摘 | Qinghang He Zhenxi Zhang Chao Yi | 2008 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2008，，3： | 1 |
| 20 | Improving the room-temperature bendability of Mg-3Al-1Zn alloy sheet by introducing a bimodal microstructure and the texture re-orientation显示文摘A significant enhancement of bendability was achieved by the introduction of bimodal microstructure for AZ31B alloy sheets via pre-compression and subsequent annealing(PCA)process.This combined treatment led to the c-axis of the extracted samples that were inclined by 30°to the rolling direction(30°sample)further shifting toward the rolling direction(RD)and resulting in a higher Schmid factor(SF)value of basal slip under the RD tensile stress.Furthermore,the bimodal microstructure that was introduced by the PCA process broke the damage bands(DBs)in the initial hot rolled AZ31B alloy sheets and gave rise to a more uniform strain distribution in the outer tension region of the bending samples,in which the tensile deformation was accommodated by the equally distributed{101^(-)2}tension twinning and basal slip.Consequently,the bimodal microstructure,shifted basal texture and the modification of DBs were responsible for the significant enhancement in the bendability of the AZ31 alloys. | Chao He Yibing Zhang Ming Yuan Bin Jiang Qinghang Wang Yanfu Chai Guangsheng Huang Dingfei Zhang Fusheng Pan | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 1 |
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