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| 1 | Oral cancer incidence and mortality in China, 2011显示文摘Objective: To descript the incidence and mortality rates of oral cancer among Chinese population in 2011, and provide valuable data for oral cancer prevention and research.Methods: Data from 177 population-based cancer registries distributed in 28 provinces were accepted for this study after evaluation based on quality control criteria, covering a total of 175,310,169 populations and accounting for 13.01% of the overall national population in 2011. Incidence and mortality rates were calculated by area, gender and age groups. The numbers of new cases and deaths were estimated using the 5-year age-specific cancer incidence/mortality rates and the corresponding populations. The Chinese population in 2000 and World Segi's population were used for age-standardized rates.Results: The estimate of new cases diagnosed with oral cancer was 39,450 including 26,160 males and 13,290 females. The overall crude incidence rate for oral cancer was 2.93/100,000. The age-standardized rates by China(ASRCN) population and by World population(ASRwld) were 2.22/100,000 and 2.17/100,000, respectively. Among subjects aged 0-74 years, the cumulative incidence rate was 0.25%. The estimated number of oral cancer deaths of China in 2011 was 16,933, including 11,794 males and 5,139 females. The overall crude mortality rate was 1.26/100,000, accounting for 0.80% of all cancer deaths. The ASRCN and ASRwld for mortality were 0.90/100,000 and 0.89/100,000, respectively. Among subjects aged 0-74 years, the cumulative mortality rate was 0.10%. The incidence and mortality rates of oral cancer were much higher in males and urban areas than in females and rural areas. In addition, the incidence and mortality rates were increased by the raising of ages.Conclusions: Results in the study may have important roles for oral cancer prevention and research. Although oral cancer burden of China is not high, we must pay attention to this malignancy as well. In addition, further researches need to be done for primary and secondary prevention research of oral cancer, especially for the high risk population. | Shao-Kai Zhang Rongshou Zheng Qiong Chen Siwei Zhang Xibin Sun Wanqing Chen | 2015 | Chinese Journal of Cancer Research2015，27，1： | 44 |
| 2 | Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential显示文摘Metastatic human HCC model is needed for the studies on mechanism and intervention of metastatic recurrence. By using orthotopic implantation of histologically intact tissues of 30 surgical specimens, a patient like metastatic model of human HCC in nude mice (LCI-D20)and a Iow metastatic model of human HCC in nude mice LCI-D35 ) have been established. All mice with transplanted LCI-D20 tumors exhibited extremely high metastatic ability including spontaneous metastasis to liver, lungs, lymph nodes and peritoneal seeding.Remarkable difference was also found in expression of some of the invasiveness related genes and growth factors between the LCI-D20 and LCI-D35 tumors. PAI-Iincreased gradually following tumor progression in LCID20 model, and correlated with tumor size and AFP level,Phasic expression of tissue intercellular adhesion molecule-I in this model was also observed. Using corneal micropocket model, it was demonstrated that the vascular response induced by LCI-D20 tumor was stronger than that induced by LCI-D35 tumor. Similar report on metastatic human HCC model in nude mice and human HCC cell line with metastatic potential was rarely found in the literature. This LCI-D20 model has been widely used for the studies on intervention of metastasis, including antiangiogenesis, antisense approach, metalloproteinase inhibitor, differentiation inducer, etc. It is concluded that the establishment of metastatic human HCC model in nude mice and human HCC cell line with metastatic potential will provide important models for the in vivo and in vitro study of HCC invasiveness, angiogenesis as well as intervention of HCC recurrence. | Zhao-You Tang Fan-Xian Sun Jian Tian Sheng-Long Ye Yin-Kun Liu Kang-Da Liu Qiong Xue Jie Chen Jing-Lin Xia Lun-Xiu Qin Hui-Chuan Sun Lu Wang Jian Zhou Yan Li Zeng-Chen Ma Xin-Da Zhou Zhi-Quan Wu Zhi-Ying Lin Bing-Hui Yang Liver Cancer Institute of Fudan University and Zhongshan Hospital,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 34 |
| 3 | Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in China.Themechanisms of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protein,which acts as an inhibitor by binding directly toCDK4 and CDK6 and preventing its association | Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of General Surgery,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China Department of Pathology,The First Affiliated Hospital,West China University of Medical Sciences,Chengdu 610041,Sichuan Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 30 |
| 4 | Oridonin induces apoptosis in gastric cancer through Apaf-1,cytochrome c and caspase-3 signaling pathway显示文摘AIM:To investigate the effect and mechanism of oridonin on the gastric cancer cell line HGC-27 in vitro.METHODS:The inhibitory effect of oridonin on HGC-27 cells was detected using the 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrazolium bromide assay.After treatment with 10 μg/mL oridonin for 24 h and 48 h,the cells were stained with acridine orange/ethidium bromide.The morphologic changes were observed under an inverted fluorescence microscope.DNA fragmen-tation(a hallmark of apoptosis) and lactate dehydrogenase activity were examined using DNA ladder assay and lactate dehydrogenase-release assay.After treated with oridonin(0,1.25,2.5,5 and 10 μg/mL),HGC-27 cells were collected for anexin V-phycoerythrin and 7-amino-actinomycin D double staining and tested by flow cytometric analysis,and oridonin-induced apoptosis in HGC-27 cells was detected.After treatment with oridonin for 24 h,the effects of oridonin on expression of Apaf-1,Bcl-2,Bax,caspase-3 and cytochrome c were also analyzed using reverse-transcript polymerase chain reaction(RT-PCR) and Western blotting.RESULTS:Oridonin significantly inhibited the proliferation of HGC-27 cells in a dose-and time-dependent manner.The inhibition rates of HGC-27 treated with four different concentrations of oridonin for 24 h(1.25,2.5,5 and 10 μg/mL) were 1.78% ± 0.36%,4.96% ± 1.59%,10.35% ± 2.76% and 41.6% ± 4.29%,respectively,which showed a significant difference(P < 0.05).The inhibition rates of HGC-27 treated with oridonin at the four concentrations for 48 h were 14.77% ± 4.21%,21.57% ± 3.75%,30.31% ± 4.91% and 61.19% ± 5.81%,with a significant difference(P < 0.05).The inhibition rates of HGC-27 treated with oridonin for 72 h at the four concentrations were 25.77% ± 4.85%,31.86% ± 3.86%,48.30% ± 4.16% and 81.80% ± 6.72%,with a significant difference(P < 0.05).Cells treated with oridonin showed typical apoptotic features with acridine orange/ethidium bromide staining.After treatment with oridonin,the cells became round,shrank,and developed small buds around the nuclear membrane while forming apoptotic bodies.Lactate dehydrogenase(LDH) release assay showed that after treated with 1.25 μg/mL and 20 μg/mL oridonin for 24 h,LDH release of HGC-27 caused by apoptosis increased from 22.94% ± 3.8% to 52.68% ± 2.4%(P < 0.001).However,the change in the release of LDH caused by necrosis was insignificant,suggesting thatthe major cause of oridonin-induced HGC-27 cell death was apoptosis.Flow cytometric analysis also revealed that oridonin induced significant apoptosis compared with the controls(P < 0.05).And the apoptosis rates of HGC-27 induced by the four different concentrations of oridonin were 5.3% ± 1.02%,12.8% ± 2.53%,28.5% ± 4.23% and 49.6% ± 3.76%,which were in a dose-dependent manner(P < 0.05).After treatment for 24 h,DNA ladder showed that oridonin induced a significant increase in DNA fragmentation in a dosedependent manner.RT-PCR revealed that mRNA expression levels were up-regulated compared with the controls in caspase-3(0.917 ± 0.103 vs 0.357 ± 0.019,P < 0.05),cytochrome c(1.429 ± 0.111 vs 1.002 ± 0.014,P < 0.05),Apaf-1(0.688 ± 0.101 vs 0.242 ± 0.037,P < 0.05) and Bax(0.856 ± 0.101 vs 0.278 ± 0.027,P < 0.05)(P < 0.05),whereas down-regulated in Bcl-2(0.085 ± 0.012 vs 0.175 ± 0.030,P < 0.05).Western blotting analysis also confirmed this result.CONCLUSION:Apoptosis of HGC-27 induced by oridonin may be associated with differential expression of Apaf-1,caspase-3 and cytochrome c,which are highly dependent upon the mitochondrial pathway. | Ke-Wang Sun Ying-Yu Ma Tian-Pei Guan Ying-Jie Xia Chang-Ming Shao Le-Gao Chen Ya-Jun Ren Hai-Bo Yao Qiong Yang Xu-Jun He | 2012 | World Journal of Gastroenterology2012，18，48： | 25 |
| 5 | Chaihu-Shugan-San exerts an antidepressive effect by downregulating miR-124 and releasing inhibition of the MAPK14 and Gria3 signaling pathways显示文摘Dysregulation of mi R-124 has been reported to be involved in the pathophysiology of depression. Chaihu-Shugan-San, a traditional Chinese medicine, has antidepressive activity; however, the underlying mechanisms remain unclear. In this study, to generate a rodent model of depression, rats were subjected to a combination of solitary confinement and chronic unpredictable mild stress for 28 days. Rats were intragastrically administered Chaihu-Shugan-San(2.835 m L/kg/d) for 4 weeks, once a day. Real-time reverse-transcription quantitative polymerase chain reaction, mi RNA microarray, western blot assay and transmission electron microscopy demonstrated that ChaihuShugan-San downregulated mi R-124 expression and upregulated the m RNA and protein levels of mitogen-activated protein kinase 14(MAPK14) and glutamate receptor subunit 3(Gria3). Chaihu-Shugan-San also promoted synapse formation in the hippocampus. The open field test, sucrose consumption test and forced swimming test were used to assess depression-like behavior. After intragastric administration of Chaihu-Shugan-San, sucrose consumption increased, while the depressive behaviors were substantially reduced. Together, these findings suggest that Chaihu-Shugan-San exerts an antidepressant-like effect by downregulating mi R-124 expression and by releasing the inhibition of the MAPK14 and Gria3 signaling pathways. | Qiong Liu Ning-Ning Sun Zheng-Zhi Wu Da-Hua Fan Mei-Qun Cao | 2018 | Neural Regeneration Research2018，13，5： | 26 |
| 6 | Tunable/Reconfigurable Metasurfaces: Physics and Applications显示文摘Metasurfaces,ultrathin metamaterials constructed by planar meta-atoms with tailored electromagnetic(EM)responses,have attracted tremendous attention due to their exotic abilities to freely control EM waves.With active elements incorporated into metasurface designs,one can realize tunable and/or reconfgurable metadevices with functionalities controlled by external stimuli,opening a new platform to dynamically manipulate EM waves.In this article,we briefy review recent progress on tunable/reconfgurable metasurfaces,focusing on their working mechanisms and practical applications.We frst describe available approaches,categorized into diferent classes based on external stimuli applied,to realize homogeneous tunable/reconfgurable metasurfaces,which can ofer uniform manipulations on EM waves.We next summarize recent achievements on inhomogeneous tunable/reconfgurable metasurfaces with constitutional meta-atoms locally tuned by external knobs,which can dynamically control the wave-fronts of EM waves.We conclude this review by presenting our own perspectives on possible future directions and existing challenges in this fast developing feld. | Qiong He Shulin Sun Lei Zhou | 2019 | Research2019，，1： | 26 |
| 7 | High-efficiency surface plasmon meta-couplers: concept and microwave-regime realizations显示文摘Surface plasmon polaritons(SPPs)and their low-frequency counterparts(i.e.,spoof SPPs on artificial surfaces)have recently found numerous applications in photonics,but traditional devices to excite them(such as gratings and prism couplers)all suffer from problems of inherent low efficiency because the generated SPPs can decouple,returning to free space,and reflections at the device surface can never be avoided.Here,we propose a new SPP excitation scheme based on a transparent gradient metasurface and numerically demonstrate that it exhibits inherently high efficiency(~94%)because the designed meta-coupler suppresses both decoupling and surface reflections.As a practical realization of this concept,we fabricated a meta-coupler for operation in the microwave regime and performed near-field and far-field experiments to demonstrate that the achieved excitation efficiency for spoof SPPs reaches~73%,which is several times higher than that achieved by other available devices in this frequency domain.Our findings can motivate the design and fabrication of high-performance plasmonic devices to harvest light–matter interactions,particularly those related to spoof SPPs in the low-frequency domain. | Wujiong Sun Qiong He Shulin Sun Lei Zhou | 2016 | Light(Science & Applications)2016，5，1： | 23 |
| 8 | Incidence and mortality of lung cancer in China, 2008-2012显示文摘Objective: To analyze the incidence and mortality rates of lung cancer in China from 2008 to 2012.Methods: Incident and death cases of lung cancer were retrieved from the National Central Cancer Registry(NCCR) database collecting from 135 cancer registries in China during 2008-2012.The crude incidence and mortality rates of lung cancer were calculated by area(urban/rural),region(eastern,middle,western),gender and age group(0,1-4,5-9,…,85+).China census in 2000 and Segi's world population were applied for agestandardized rates.JoinPoint(Version 4.5.0.1) model was used for time trend analysis.Results: The crude incidence rate of lung cancer was 54.66/100,000 which ranked the first in overall cancers.The age-standardized incidence rates by China population(ASIRC) and by World population(ASIRW) were35.13/100,000 and 34.86/100,000,respectively.The crude mortality of lung cancer in China was 45.60/100,000 and it was the first cause of cancer-related death in overall cancers.The age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 28.57/100,000 and 28.22/100,000,respectively.Incidence and mortality rates of lung cancer were higher in males than in females and higher in urban areas than in rural areas.Eastern areas had the highest incidence and mortality rates followed by middle and western areas.Incidence and mortality rates of lung cancer retained low level in age groups before 40 years old but increased greatly after and peaked in age group of 80-84.During 2003-2012,the temporal trend of the incidence rate of lung cancer in both sexes in China was general stable(P<0.05).The lung cancer incidence rate increased by 0.71% per year in females(P<0.05) and 2.26% per year in rural areas(P<0.05).The mortality rate of lung cancer decreased slightly annually during 2003-2012 in China(P>0.05).In urban areas,it declined by 0.76%per year(P<0.05),but rose by 2.09% per year(P<0.05) in rural areas.Conclusions: Appropriate targeted prevention,early detection and treatment programs should be carried out to control the local burden of lung cancer. | Shuzheng Liu Qiong Chen Lanwei Guo Xiaoqin Cao Xibin Sun Wanqing Chen Jie He | 2018 | Chinese Journal of Cancer Research2018，30，6： | 19 |
| 9 | Study of angiogenesis induced by metastatic and non-metastatic liver cancer by corneal micropocket model in nude mice显示文摘METHODSCornealmicropocketswerecreatedinnudemice.Tumortissuesandlivertissueswereimplantedintothecornealmicropockets.Angiogenes... | SUN Hui Chuan, LI Xiao Ming, XUE Qiong, CHEN Jun, GAO Dong Mei and TANG Zhao You | 1999 | World Journal of Gastroenterology1999，5，2： | 17 |
| 10 | Changes in temperature extremes in the Yangtze River Basin, 1962-2011显示文摘Based on daily maximum and minimum temperature observed by the China Meteorological Administration at 115 meteorological stations in the Yangtze River Basin from 1962 to 2011,the methods of linear regression,principal component analysis and correlation analysis are employed to investigate the temporal variability and spatial distribution of temperature extremes.Sixteen indices of extreme temperature are selected.The results are as follows:(1) The occurrence of cold days,cold nights,ice days,frost days and cold spell duration indicator has significantly decreased by –0.84,–2.78,–0.48,–3.29 and –0.67 days per decade,respectively.While the occurrence of warm days,warm nights,summer days,tropical nights,warm spell duration indicator and growing season length shows statistically significant increasing trends at rates of 2.24,2.86,2.93,1.80,0.83 and 2.30 days per decade,respectively.The tendency rate of the coldest day,coldest night,warmest day,warmest night and diurnal temperature range is 0.33,0.47,0.16,0.19 and –0.07℃ per decade,respectively.(2) The magnitudes of changes in cold indices(cold nights,coldest day and coldest night) are obviously greater than those of warm indices(warm nights,warmest day and warmest night).The change ranges of night indices(warm nights and cold nights) are larger than those of day indices(warm days and cold days),which indicates that the change of day and night temperature is asymmetrical.(3) Spatially,the regionally averaged values of cold indices in the upper reaches of the Yangtze River Basin are larger than those in the middle and lower reaches.However,the regionally averaged values of most warm indices(except warm spell duration indicator) and growing season length in the middle and lower reaches are larger than those in the upper reaches.(4) The extreme temperature indices are well correlated with each other except diurnal temperature range. | WANG Qiong ZHANG Mingjun WANG Shengjie MA Qian SUN Meiping | 2014 | Journal of Geographical Sciences2014，24，1： | 14 |
| 11 | Dyslipidaemia among diabetic patients with ischemic stroke in a Chinese hospital显示文摘背景 Dyslipidaemia 是一个潜在的独立风险因素因为在有这研究的 diabetes.The 目的病人的脑血管的疾病是调查 dyslipidaemia ,在有 ischemic 的糖尿病的病人之中的 dyslipidaemia 的治疗和控制在中国 hospital.Methods 摸 2 个糖尿病的病人被分到糖尿病与的 1046 类型的一个总数( n=522 )并且没有中风 groups.The 的糖尿病二个组被性,年龄和糖尿病匹配 duration.Lipid 和脂蛋白侧面是 measured. | WANG Shao-hua SUN Zi-lin RUAN Xiong-zhong GUO Yi-jing WANG Yao JIN Hui YUAN Yang WEI Qiong | 2009 | Chinese Medical Journal2009，，21： | 11 |
| 12 | Controlling angular dispersions in optical metasurfaces显示文摘Although metasurfaces have shown great potential for manipulating light,most previously realized meta-devices suffer from uncontrolled angular dispersions,making them unfavorable for many applications.Here,we propose a general strategy to realize optical metasurfaces with desired angular dispersions based on carefully controlling both the near-field couplings between meta-atoms and the radiation pattern of a single meta-atom.Utilizing such a strategy,we experimentally demonstrate a series of optical meta-devices with predesigned angular dispersions,including two incident-angle-insensitive absorbers,one incident-angle-selective absorber,and one multifunctional meta-polarizer whose functionality changes from a perfect mirror to a half-waveplate as the excitation angle varies.Finally,we design a gradient meta-device using meta-atom arrays with purposely controlled angular dispersions and numerically demonstrate that it can exhibit distinct wavefront-control functionalities when illuminated at different incident angles.Our findings establish a new platform for achieving angle-multiplexed functional meta-devices,significantly expanding the wave-manipulation capabilities of optical metasurfaces. | Xiyue Zhang Qi Li Feifei Liu Meng Qiu Shulin Sun Qiong He Lei Zhou | 2020 | Light(Science & Applications)2020，9，1： | 11 |
| 13 | Microstructure evolution of AZ91 alloy processed by a combination method of equal channel angular pressing and rolling显示文摘In the present work,AZ91 alloy was successfully processed by equal channel angular pressing(ECAP)for up to 16 passes and rolling(R)for multiple passes with a total reduction of 75%in addition to a combination method with ECAP plus rolling(ECAP+R).The effects of various processes(ECAP,R and ECAP+R)on microstructure evolution were analyzed and the influence of ECAP process on the rolling performance was examined.The result shows that ECAP contributed to a homogenous grain structure and formed a texture with higher Schmidt factors that was easy for rolling.A plate with smoother surface and reduced edge cracks was observed in the ECAP+R process than in the single R process.Although the microstructure of the alloy was similar after ECAP+R and R process,the sample of ECAP+R was more refined and had stronger second phase precipitation than the sample of R,which resulted in better rolling characteristics,along with the external surfaces. | Qiong Xu Aibin Ma Yuhua Li Jiapeng Sun Yuchun Yuan Jinghua Jiang Chaoying Ni | 2020 | Journal of Magnesium and Alloys2020，8，1： | 10 |
| 14 | Crystal structure of the swine-origin A (H1N1)- 2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus显示文摘Influenza virus is the causative agent of the seasonal and occasional pandemic flu.The current H1N1 influenza pandemic,announced by the WHO in June 2009,is highly contagious and responsible for global economic losses and fatalities.Although the H1N1 gene segments have three origins in terms of host species,the virus has been named swine-origin influenza virus(S-OIV)due to a predominant swine origin.2009 S-OIV has been shown to highly resemble the 1918 pandemic virus in many aspects.Hemagglutinin is responsible for the host range and receptor binding of the virus and is therefore a primary indicator for the potential of infection.Primary sequence analysis of the 2009 S-OIV hemagglutinin(HA)reveals its closest relationship to that of the 1918 pandemic influenza virus,however,analysis at the structural level is necessary to critically assess the functional significance.In this report,we report the crystal structure of soluble hemagglutinin H1(09H1)at 2.9Å,illustrating that the 09H1 is very similar to the 1918 pandemic HA(18H1)in overall structure and the structural modules,including the five defined antiboby(Ab)-binding epitopes.Our results provide an explanation as to why sera from the survivors of the 1918 pandemics can neutralize the 2009 S-OIV,and people born around the 1918 are resistant to the current pandemic,yet younger generations are more susceptible to the 2009 pandemic. | Wei Zhang Jianxun Qi Yi Shi Qing Li Feng Gao Yeping Sun Xishan Lu Qiong Lu Christopher J.Vavricka Di Liu Jinghua Yan George F.Gao | 2010 | Protein & Cell2010，1，5： | 10 |
| 15 | Efficient manipulations of circularly polarized terahertz waves with transmissive metasurfaces显示文摘The unrestricted control of circularly polarized(CP)terahertz(THz)waves is important in science and applications,but conventional THz devices suffer from issues of bulky size and low efficiency.Although Pancharatnam-Berry(PB)metasurfaces have shown strong capabilities to control CP waves,transmission-mode PB devices realized in the THz regime are less efficient,limiting their applications in practice.Here,based on Jones matrix analysis,we design a trilayer structure(thickness of ~λ/5)and experimentally demonstrate that the structure can serve as a highly efficient transmissive meta-atom(relative efficiency of ~90%)to build PB metadevices for manipulating CP THz waves.Two ultrathin THz metadevices are fabricated and experimentally characterized with a z-scan THz imaging system.The first device can realize a photonic spin Hall effect with an experimentally demonstrated relative efficiency of ~90%,whereas the second device can generate a high-quality background-free CP Bessel beam with measured longitudinal and transverse field patterns that exhibit the nondiffracting characteristics of a Bessel beam.All the experimental results are in excellent agreement with full-wave simulations.Our results pave the way to freely manipulate CP THz beams,laying a solid basis for future applications such as biomolecular control and THz signal transportation. | Min Jia Zhuo Wang Heting Li Xinke Wang Weijie Luo Shulin Sun Yan Zhang Qiong He Lei Zhou | 2019 | Light(Science & Applications)2019，8，1： | 9 |
| 16 | Chemical characteristics of size-resolved aerosols in winter in Beijing显示文摘Size-resolved aerosols were continuously collected by a Nano Sampler for 13 days at an urban site in Beijing during winter 2012 to measure the chemical composition of ambient aerosol particles. Data collected by the Nano Sampler and an ACSM(Aerodyne Aerosol Chemical Speciation Monitor) were compared. Between the data sets,similar trends and strong correlations were observed,demonstrating the validity of the Nano Sampler. PM10 and PM2.5concentrations during the measurement were 150.5 ± 96.0 μg/m3(mean ± standard variation)and 106.9 ± 71.6 μg/m3,respectively. The PM2.5/PM10 ratio was 0.70 ± 0.10,indicating that PM2.5dominated PM10. The aerosol size distributions showed that three size bins of 0.5–1,1–2.5 and 2.5–10 μm contributed 21.8%,23.3% and 26.0% to the total mass concentration(TMC),respectively. OM(organic matter) and SIA(secondary ionic aerosol,mainly SO42-,NO3-and NH4+) were major components of PM2.5. Secondary compounds(SIA and secondary organic carbon) accounted for half of TMC(about 49.8%) in PM2.5,and suggested that secondary aerosols significantly contributed to the serious particulate matter pollution observed in winter. Coal burning,biomass combustion,vehicle emissions and SIA were found to be the main sources of PM2.5. Mass concentrations of water-soluble ions and undetected materials,as well as their fractions in TMC,strikingly increased with deteriorating particle pollution conditions,while OM and EC(elemental carbon) exhibited different variations,with mass concentrations slightly increasing but fractions in TMC decreasing. | Kang Sun Yu Qu Qiong Wu Tingting Han Jianwei Gu Jingjing Zhao Yele Sun Qi Jiang Ziqi Gao Min Hu Yuanhang Zhang Keding Lu Stephan Nordmann Yafang Cheng Li Hou Hui Ge Masami Furuuchi Mitsuhiko Hata Xingang Liu | 2014 | Journal of Environmental Sciences2014，26，8： | 9 |
| 17 | Combination of acoustic radiation force impulse imaging, serological indexes and contrast-enhanced ultrasound for diagnosis of liver lesions显示文摘AIM To assess the value of combined acoustic radiation force impulse(ARFI) imaging, serological indexes and contrast-enhanced ultrasound(CEUS) in distinguishing between benign and malignant liver lesions. METHODS Patients with liver lesions treated at our hospital were included in this study. The lesions were divided into either a malignant tumor group or a benign tumor group according to pathological or radiological findings. ARFI quantitative detection, serological testing and CEUS quantitative detection were performed and compared. A comparative analysis of the measured indexes was performed between these groups. Receiver operating characteristic(ROC) curves were constructed to compare the diagnostic accuracy of ARFI imaging, serological indexes and CEUS, alone or in different combinations, in identifying benign and malignant liver lesions. RESULTS A total of 112 liver lesions in 43 patients were included, of which 78 were malignant and 34 were benign. Shear wave velocity(SWV) value, serum alpha-fetoprotein(AFP) content and enhancement rate were significantly higher in the malignant tumor group than in the benign tumor group(2.39 ± 1.20 m/s vs 1.50 ± 0.49 m/s, 18.02 ± 5.01 ng/m L vs 15.96 ± 4.33 ng/m L, 2.14 ± 0.21 d B/s vs 2.01 ± 0.31 d B/s; P < 0.05). The ROC curve analysis revealed that the areas under the curves(AUCs) of SWV value alone, AFP content alone, enhancement rate alone, SWV value + AFP content, SWV value + enhancement rate, AFP content + enhancement rate and SWV value + AFP content + enhancement rate were 85.1%, 72.1%, 74.5%, 88.3%, 90.4%, 82.0% and 92.3%, respectively. The AUC of SWV value + AFP content + enhancement rate was higher than those of SWV value + AFP content and SWV value + enhancement rate, and significantly higher than those of any single parameter or the combination of any two of parameters.CONCLUSION The combination of SWV, AFP and enhancement rate had better diagnostic performance in distinguishing between benign and malignant liver lesions than the use of any single parameter or the combination of any two of parameters. It is expected that this would provide a tool for the differential diagnosis of benign and malignant liver lesions. | Xiao-Lan Sun Hui Yao Qiong Men Ke-Zhu Hou Zhen Chen Chang-Qing Xu Li-Wei Liang | 2017 | World Journal of Gastroenterology2017，23，30： | 8 |
| 18 | Peripheral CD4^(+) T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer显示文摘Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients.Herein,we have investigated peripheral CD4^(+) T cell signatures in advanced non-small cell lung cancer(NSCLC)patients receiving anti-PD-1/PD-L1 treatments.It was found that the percentages of IFN-γand IL-17A secreting naïve CD4^(+) T cells(Tn),and memory CD4^(+) T cells(Tm)expressing PD-1,PD-L1 and CTLA-4 were significantly higher in responder(R)than non-responder(NonR)NSCLC patients associated with a longer progression free survival(PFS).Logistic regression analysis revealed that the baseline IFN-γ-producing CD4^(+) Tn cells and PD-1^(+)CD4^(+) Tm cells were the most significant signatures with the area under curve(AUC)value reaching 0.849.This was further validated in another anti-PD-1 monotherapy cohort.Conversely,high percentage of CTLA-4^(+)CD4^(+) Tm cells was associated with a shorter PFS in patients receiving anti-PD-L1 monotherapy.Our study therefore elucidates the significance of functional CD4^(+) Tn and Tm subpopulations before the treatment in predicting the responses to anti-PD-1 treatment in Chinese NSCLC patients.The fact that there display distinct CD4^(+) T cell signatures in the prediction to anti-PD-1 and anti-PD-L1 monotherapy from our study provides preliminary evidence on the feasibility of anti-PD-1 and anti-PD-L1 combination therapy for advanced NSCLC patients. | Liliang Xia Hui Wang Mingjiao Sun Yi Yang Chengcheng Yao Sheng He Huangqi Duan Weimin Xia Ruiming Sun Yaxian Yao Zhiwei Chen Qiong Zhao Hong Li Shun Lu Ying Wang | 2021 | Science China(Life Sciences)2021，64，10： | 7 |
| 19 | Characterization of mechanochemical treated fly ash from a medical waste incinerator显示文摘The mechanochemical treatment of fly ash generated from a medical waste incinerator was subjected to grinding for 2 hr at 400 r/min in a planetary ball mill.The treated fly ash was characterized by a suite of analytical methods including High Resolution Gas Chromatograph/High Resolution Mass Spectrometer,Mastersizer 2000 Particle Size Analyzer,QUADRASORBTM SI Surface Area Analyzer,Scanning Electron Microscopy and X-ray diffraction.Results showed that abatement effciency of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans(PCDDs/Fs) in terms of total concentration averagely amount to 76%which was relatively higher than that of I-TEQ concentration averagely amount to 56%;the most concentration of toxic congeners as well as isomers of PCDDs/Fs decreased after mechanochemical treatment.The treated fly ash was characterized by a more homogeneous distribution of concaves as well as the significant decreasing in overall particle size and great enlargement in surface area.The major crystallization phases or intensities were considerably changed by mechanochemical treatment,of which a new phase containing chlorine formed may be a possible factor suggesting chlorination reaction occurring on the crystalline surface. | Zheng Peng Qiong Ding Yangzhao Sun Chen Jiang Xinhua Gao Jianhua Yan | 2010 | Journal of Environmental Sciences2010，22，10： | 7 |
| 20 | Tensile properties and fracture behavior of Ti_2AlNb based alloys at room temperature显示文摘The tensile mechanical properties and fracture behaviors of Ti 22Al 20Nb 7Ta alloys were studied at room temperature. Three typical microstructures of Ti 2AlNb based alloys were obtained by combination of thermal mechanical processing and heat treat ment. They are: 1) lath mixture of O + B 2 with remaining β grain boundaries and α 2 phase; 2) equiaxed O phase in B 2 matrix; 3) fine lath mixture of O + B 2 without remaining β grain boundaries. It is shown that the microstructure obviously affects the tensile properties of Ti 2AlNb based alloys. The microstructure of fine lath mixture of O + B 2 without remaining β grain boundaries has good combination of yield stress and ductility, while the microstructure with lath mixture of O + B 2 with remaining β grain boundaries and α 2 phase has low yield stress and elongation. The fracture mode was also controlled by the microstructure of Ti 2AlNb based alloys. By means of SEM, it was found that the dominated fracture mode of microstructure with lath mixture of O + B 2 with remained β grain boundary and α 2 phase was intergranular, and the fracture mode of the other two microstructures was mainly transgranular. | PENG Ji hua(彭继华) 1, 2 , MAO Yong(毛 勇) 2, LI Shi qiong(李世琼) 2, SUN Xun fang(孙训方) 2 1. Department of Engineering Mechanics, Southwest Jiaotong University, Chengdu 610031, P.R.China 2. Division of Super Alloys, Central Iron and S | 2000 | 中国有色金属学会会刊:英文版2000，10，3： | 6 |
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