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| 1 | WIRELESS BODY-AREA NETWORKS显示文摘The last decade has witnessed the convergence of three giant worlds:electronics,computer science and telecommunications.The next decade should follow this convergence in most of our activities with the generalization of sensor networks.In particular with the progress in medicine,people live longer and the aging of population will push the development of wireless person- | CHEN Wen Benoit Geller HU Fengye JIANG Ting WANG Qixin | 2015 | China Communications2015，12，2： | 0 |
| 2 | The genetic and molecular basis for improving heat stress tolerance in wheat显示文摘Wheat production requires at least-2.4%increase per year rate by 2050 globally to meet food demands.However,heat stress results in serious yield loss of wheat worldwide.Correspondingly,wheat has evolved genetic basis and molecular mechanisms to protect themselves from heat-induced damage.Thus,it is very urgent to understand the underlying genetic basis and molecular mechanisms responsive to elevated temperatures to provide important strategies for heat-tolerant varieties breeding.In this review,we focused on the impact of heat stress on morphology variation at adult stage in wheat breeding programs.We also summarize the recent studies of genetic and molecular factors regulating heat tolerance,including identification of heat stress tolerance related QTLs/genes,and the regulation pathway in response to heat stress.In addition,we discuss the potential ways to improve heat tolerance by developing new technologies such as genome editing.This review of wheat responses to heat stress may shed light on the understanding heat-responsive mechanisms,although the regu-latory network of heat tolerance is still ambiguous in wheat. | Lv Sun Jingjing Wen Huiru Peng Yingyin Yao Zhaorong Hu Zhongfu Ni Qixin Sun Mingming Xin | 2022 | aBIOTECH2022，3，1： | 0 |
| 3 | Cerebral furin deficiency causes hydrocephalus in mice显示文摘Furin is a pro-protein convertase that moves between the trans-Golgi network and cell surface in the secretory pathway.We have previously reported that cerebral overexpres-sion of furin promotes cognitive functions in mice.Here,by generating the brain-specific furin conditional knockout(ckO)mice,we investigated the role of furin in brain development.We found that furin deficiency caused early death and growth retardation.Magnetic resonance im-aging showed severe hydrocephalus.In the brain of furin cko mice,impaired ciliogenesis and the derangement of microtubule structures appeared along with the down-regulated expres-sion of RAB28,a ciliary vesicle protein.In line with the widespread neuronal loss,ependymal cell layers were damaged.Further proteomics analysis revealed that cell adhesion molecules including astrocyte-enriched ITGB8 and BCAR1 were altered in furin cKO mice;and astrocyte overgrowth was accompanied by the reduced expression of sox9,indicating a disrupted differ-entiation into ependymal cells.Together,whereas alteration of RAB28 expression correlated with the role of vesicle trafficking in ciliogenesis,dysfunctional astrocytes might be involved in ependymal damage contributing to hydrocephalus in furin ckO mice.The structural and mo-lecular alterations provided a clue for further studying the potential mechanisms of furin. | Shiqi Xie Xiaoyong Xie Jing Tang Biao Luo Jian Chen Qixin Wen Jianrong Zhou Guojun Chen | 2024 | Genes & Diseases2024，11，3： | 0 |
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