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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Ge- netic diversity and drug resistance among newly diagnosed and antiretroviral treatment-naive HIV-infected individuals in western Yunnan: a hot area of viral recombination in China 显示文摘 | Chen M Ma Y Duan S Xing H Yao S Su Y Luo H Yang L Chen H Fu L Qu A Ou CY Jia M Lu L | 2012 | BMC Infect Dis2012，12，： | 1 |
| 3 | Fabrication of Superhydrophobic Surfaces on Engineering Materials by a Solution-Immersion Process显示文摘 | QU M ZHANG B SONG S | | 0，，： | 1 |
| 4 | Evaluation o{ runo{{ responses to land use/cover changes in the upper Huaihe river basin, China 显示文摘 | Qu S M Bao W M Shi P | 2009 | Journal of Hydrologic Engineering2009，17，7： | 1 |
| 5 | Simulation of carbon-based model for virtual plants as complex adaptive system显示文摘 | Qu H C Zhu Q S Guo M W | 2010 | Simulation Modelling Practice and Theory2010，18，6： | 1 |
| 6 | 显示文摘 | ZHANG Y P YE X W TIAN M K QU L B CHOI S H GOPALAN A I LEE K P | 2008 | J Chromatogr: A2008，1188，1： | 1 |
| 7 | Relationship between cardiomyocyte cell death and cardiac function during hypertensive cardiac remodelling in Dahl rats显示文摘 | Ikeda S Hamada M Qu P | 2002 | Clin Sci (Lond)2002，102，3： | 1 |
| 8 | Spotted leaf 11, a negative regulator of plant cell death and defense, encodes a U-Box/Armadillo repeat protein endowed with E3 Ubiquitin ligase activity显示文摘 | Zeng L Qu S Bordeos A Yang C Baraoidan M Yan H Xie Q Nahm B Leung H Wang G | 2004 | The Plant Cell2004，16，10： | 1 |
| 9 | Biosolids and sludge management显示文摘 | Krogmann U Qu M Boyles L S | 1997 | Water Environ Res1997，69，4： | 1 |
| 10 | Multifrequency minimum shift keying 显示文摘 | FLEISHER S M QU SHOUXING | 1992 | IEEE Journal on Selected Areas in Communications1992，10，8： | 1 |
| 11 | Mutivariate analysis of heavy metal and nutrient concentrations in sediments of Taihu Lake,China显示文摘 | Qu W C Dickman M Wang S | | 0，，1： | 1 |
| 12 | Neonatal Necrotizing enterocolitis : clinical considerations and pathogenetic 显示文摘 | Hsueh W Caplsn M S Qu x W | 2003 | Pediatr Dev Pathol2003，6，1： | 1 |
| 13 | Introducing a strain-hardening capability to improve the ductility of bulk metallic glasses via severe plastic deformation 显示文摘 | WANG Y B QU D D WANG W H CAO Y LIAO X Z KAWASAKI M RINGER S P SHAN Z W LANGDON T G SHEN J | 2012 | Acta Mater2012，60，： | 1 |
| 14 | Antioxidant activities of different fractions of polysaccharide conjugates from green tea (Camellia Sinensis)显示文摘 | Chen H X Zhang M Qu z s | 2008 | Food Chem2008，106，2： | 1 |
| 15 | Coordination of stocking decisions in an assemble-to-order environment显示文摘 | Zhang X H Qu J H Gilbert S M | 2008 | European Journal of Operational Research2008，189，2： | 1 |
| 16 | A confidence limit for the Empirical Mode Decomposition and Hilbert Spectral Analysis显示文摘 | Huang N E Wu M L Long S R Shen S S Qu W D Gloersen p and Fan K L | 2003 | Proceedings Royal Society of London2003，459，： | 1 |
| 17 | Tectonic implications from Re-Os dating of Mesozoic molybdenum deposits in the East Qinling-Dabie orogenic belt显示文摘 | Mao J W Xie G Q Bierlein F Ye H S Qu W J Du A D Pirajno F Li H M Guo B J Li Y F and Yang Z Q | | 0，，： | 1 |
| 18 | Circulating microRNA 483-5p as a novel biomarker for diagnosis survival prediction in multiple myeloma 显示文摘 | Qu X Zhao M Wu S | 2014 | MedOncol2014，31，10： | 1 |
| 19 | Failure analysis of the 1 st stage blades in gas turbine engine 显示文摘 | Qu S Fu C M Dong C | 2013 | Engineering Failure Analysis2013，32，： | 1 |
| 20 | Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay 显示文摘 | Sun Y Liang M Qu J Jin C Zhang Q Li J Jiang X Wang Q Lu J Gu W Zhang S Li C Wang X Zhan F Yao W Bi Z Wang S Li D | 2012 | J Clin Virol2012，53，1： | 1 |
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