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| 1 | Vascular endothelial growth factor trap-eye(Aflibercept) for the management of diabetic macular edema显示文摘Diabetic retinopathy(DR)is the most common cause of visual loss among working age individuals.Diabetic macular edema(DME)is an important complication of DR that affects around one third of the patients with DR.Several treatments have been approved for DME ranging from blood pressure and glycemic control to photocoagulation and more recently the use of vascular endothelial growth factor(VEGF)antagonists.The index review discusses aflibercept(EYLEA-Regeneron Pharmaceuticals,Inc.,Tarrytown,New York,NY,and Bayer Healthcare Pharmaceuticals,Berlin,Germany)in the context of other VEGF antagonists currently available for the treatment of DME.A systematic search of literature was conducted on PubMed,Scopus,and Google Scholar with no limitation on language or year of publication.Pre-clinical studies of aflibercept have shown a higher affinity of this molecule for vascular endothelial growth factor A(VEGF-A)along with a longer duration of action as compared to other VEGF antagonists.Recent clinical trials have shown visual outcome results for aflibercept to be similarly favorable as compared to other available agents with the added benefit of fewer required injections and less frequent monitoring.Aflibercept presents a potential exciting new addition to the armamentarium of current VEGF antagonists available for the treatment of DME and other retinal vascular diseases.However,further studies are indicated to confirm the role,safety,and efficacy of aflibercept for DME. | Ahmadreza Moradi Yasir Jamal Sepah Mohammad Ali Sadiq Humzah Nasir Salima Kherani Raafay Sophie Diana V Do Quan Dong Nguyen | 2013 | World Journal of Diabetes2013，4，6： | 8 |
| 2 | Recurrent adult Wilms tumor with extensive metastases on FDG PETCT显示文摘 | HO L QUAN V PARK S | 2008 | Clin Nucl Med2008，33，2： | 1 |
| 3 | Continuous Selections,Collectively Fixed Points and Weak Knaster-Kuratowski-Mazurkiewicz Mappings in Optimization显示文摘 | Khanh P Q Long V S T Quan N H | | 0，，： | 1 |
| 4 | Everyday serendipity as described in social media显示文摘 | Rubin V L Burkell J Quan - Haase A | 2010 | Proceedings of the American Society for Information Science and Technology2010，47，1： | 1 |
| 5 | Optimization of ultrasound-assisted extraction conditions for euphol from the medicinal plant, Euphorbia tirucalli, using response surface methodology显示文摘 | Quan V Vuong Van Tang Nguyen Dang Trung Thanh | 2015 | Industrial Crops and Products2015，63，1： | 1 |
| 6 | Coding algorithms for defining Comorbidities in ICD-9-CM and ICD-10 administrative da- ta 显示文摘 | Quan H Sundararajan V Halfon P | 2005 | MedCare2005，43，11： | 1 |
| 7 | A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation 显示文摘 | DENIC V QUAN E M WEISSMAN J S | 2006 | Cell2006，126，： | 1 |
| 8 | Regiospecific synthesis of polysubstituted phenols via the palladium-catalyzed enyne-diyne cross-benzannulation pathway 显示文摘 | Quan L-G | 1998 | J Org Chem1998，，63： | 1 |
| 9 | Recurrent adult Wilms tumor with extensive metastases on FDG PET-CT显示文摘 | Ho L Quan V Park S | 2008 | Clin Nucl Med2008，33，2： | 1 |
| 10 | Botanical,Phytochemical,and Anticancer Properties of the Eucalyptus Species显示文摘 | QUAN V V ANITA C C DEEP J B | 2015 | Chemistry&Biodiversity2015，12，6： | 1 |
| 11 | Polymethyl-thiophene/Nafion-modified glassy carbonelectrode for selective detection of dopamine in thepresence of ascorbic acid显示文摘 | Huong V T Shimanouchi T Quan D P | 2009 | J Appl Electrochem2009，39，： | 1 |
| 12 | Preparation of Decaffeinated and High Caffeine Powders from Black Tea 显示文摘 | QUAN V V JOHN B G MINH H N | 2013 | Powder Technology2013，233，： | 1 |
| 13 | NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression 显示文摘 | Zhang Quan Chen C Yedavalli V S | 2013 | MBio2013，4，00： | 1 |
| 14 | Collaborative Wide- band Sensing for Cognitive Radios 显示文摘 | Quan Zhi Cui Shu-guang Poor H V | 2008 | IEEE Signal Processing Magazine2008，25，6： | 1 |
| 15 | Optimal multiband joint detection for spectrum sensing in cognitive radio networks 显示文摘 | ZHI Quan SAYED A H POOR H V | 2009 | IEEE Transactions on Signal Processing2009，57，3： | 1 |
| 16 | Semantic Caching and Query Processing显示文摘 | Ren Quan Margaret H D Kumar V | 2003 | IEEE Transactions on Knowledge and Data Engineering2003，15，1： | 1 |
| 17 | Methicillin-resistant Staphylo- coccus aureus burden in nursing homes associated with environ- mental contamination of common areas 显示文摘 | Murphy CR Ells SJ Quan V | | J Am Geriatr Soc0，60，6： | 1 |
| 18 | The role of pharmacogenetics and advances in gene therapy in the treatment of diabetic retinopathy显示文摘 | Aniruddha Agarwal Sally A Ingham Keegan A Harkins Diana V Do Quan Dong Nguyen | 2016 | Pharmacogenomics2016，，0： | 1 |
| 19 | Bats are a major natural reservoir for hepaeiviruses and pegiviruses显示文摘 | Quan P L Firth C Conte J M Williams S H Zam- brana-Torrelio C M Anthony S J Ellison J A Gilbert A T Kuzmin I V Niezgoda M Osinubi M O Re-cuenco S Markotter W Breiman R F Kalemba L Malekani J Lindblade K A Rostal M K Ojeda-Flores R Suzan G Davis L B Blau D M Ogunkoya A B Alvarez Castillo D A Moran D Ngam S Akaibe D Agwanda B Briese T Epstein J H Daszak P Rup- precht C E Holmes E C Lipkin W I | 2013 | PNAS2013，110，20： | 1 |
| 20 | Collaborative wideband sensing for cognitive radios 显示文摘 | QUAN Z CUI S POOR H V | 2008 | IEEE Signal Processing Magazine2008，25，6： | 1 |
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