|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sirtuin 5:a review of structure,known inhibitors and clues for developing new inhibitors显示文摘Sirtuins(SIRTs) are nicotinamide adenine dinucleotide(NAD^+)-dependent protein deacetylases,which regulate important biological processes ranging from apoptosis,age-associated pathophysiologies,adipocyte and muscle differentiation,and energy expenditure to gluconeogenesis.Very recently,sirtuin 5(SIRT5) has received considerable attention due to that it was found to have weak deacetylase activity but strong desuccinylase,demalonylase and deglutarylase activities,and it was also found to be associated with several human diseases such as cancer,Alzheimer's disease,and Parkinson's disease.In this review,we for the first time summarized the structure characteristics,known peptide and small-molecule inhibitors of SIRT5,extracted some clues from current available information and introduced some feasible,practical in silico methods,which might be useful in further efforts to develop new SIRT5 inhibitors. | Lingling Yang Xiaobo Ma Yanying He Chen Yuan Quanlong Chen Guobo Li Xianggui Chen | 2017 | Science China(Life Sciences)2017，60，3： | 7 |
| 2 | CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis显示文摘躲避 TGF -- 调停的生长抑制经常在肝与 tumorigenesis 被联系,包括 hepatocellular 癌(HCC ) 。更好在 HCC 开始和前进理解功能和 TGF- 的内在的分子的机制,我们执行了定序的 transcriptome (RNA-Seq ) 识别 TGF- 的目标基因。CXXC5, CXXC 类型锌手指的一个成员包含域的蛋白质家庭,在 Hep3B HCC 房间作为新奇 TGF- 目标基因被识别。稀释的 CXXC5 击倒 TGF- 目标基因和改善 TGF 的实质的部分的表示 -- 导致的生长抑制或 Hep3B 细胞的 apoptosis,建议那 CXXC5 为 TGF 被要求 -- HCC 的调停的抑制前进。TCGA 数据库的分析显示那 CXXC5 表情在正常纸巾与那相比在 HCC 织物样品的多数被减少。而且, CXXC5 与 histone deacetylase HDAC1 联系并且竞争它和 Smad2/3 的相互作用,从而在 TGF- 发信号上废除 HDAC1 的禁止的效果。这些观察一起建议 CXXC5 可以由支持经由一个积极反馈环发信号的 TGF- 充当肿瘤 suppressor,并且揭示策略让 HCC 绕过 TGF -- 由破坏积极反馈规定的调停的 cytostasis。我们的调查结果在表明规定的 TGF- 上打开新灯并且在 HCC 开发表明 CXXC5 的函数。 | Xiaohua Yan Jingyi Wu Quanlong Jiang Hao Cheng Jing-Dong J. Han Ye-Guang Chen | 2018 | Journal of Molecular Cell Biology2018，10，1： | 3 |
| 3 | Broadband terahertz rotator with an all-dielectric metasurface显示文摘Polarization manipulation is essential in developing cutting-edge photonic devices ranging from optical communication displays to solar energy harvesting. Most previous works for efficient polarization control cannot avoid utilizing metallic components that inevitably suffer from large ohmic loss and thus low operational efficiency.Replacing metallic components with Mie resonance-based dielectric resonators will largely suppress the ohmic loss toward high-efficiency metamaterial devices. Here, we propose an efficient approach for broadband, highquality polarization rotation operating in transmission mode with all-dielectric metamaterials in the terahertz regime. By separating the orthogonal polarization components in space, we obtain rotated output waves with a conversion efficiency of 67.5%. The proposed polarization manipulation strategy shows impressive robustness and flexibility in designing metadevices of both linear-and circular-polarization incidences. | QUANLONG YANG XIEYU CHEN QUAN XU CHUNXIU TIAN YUEHONG XU LONGQING CONG XUEQIAN ZHANG YANFENG LI CAIHONG ZHANG XIXIANG ZHANG JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，，11： | 2 |
| 4 | Gd-doped CuBi_(2)O_(4)/CuO heterojunction film photocathodes for photoelectrochemical H_(2)O_(2)production through oxygen reduction显示文摘Photoelectrochemical oxygen reduction reaction(ORR)toward H_(2)O_(2)is highly desirable because only sunlight,O_(2)and water are required in the process.However,the corresponding studies are still at its infancy because of the lack of suitable photocathodes,especially inorganic semiconductor photocathodes.In this work,we report CuBi_(2)O_(4)/CuO(CBO/CuO)heterojunction submicrocrystalline film photocathodes with efficient ORR activity for H_(2)O_(2)production.The heterojunction film photocathodes were prepared through thermal evaporation of Cu and Bi metals under vacuum and subsequent annealing treatment.Furthermore,the doping of Gd^(3+)ions into CBO/CuO could significantly enhance the yield of H_(2)O_(2).As a result,the concentration of H_(2)O_(2)could reach 1.3 mM within 30 min,which is 6 times higher than that obtained on the pristine CBO/CuO photocathode.The theoretical calculations suggested that the introduction of Gd could adjust the electronic structure of CBO surface and promote 2e ORR pathway for selective production of H_(2)O_(2).Our work not only provides a new strategy for designing highly efficient photocathode for H_(2)O_(2)production but also will evoke more interest in photoelectrocatalytic ORR through inorganic semiconductor photocathode. | Zixin Li Quanlong Xu Faliang Gou Bing He Wei Chen Weiwei Zheng Xu Jiang Kai Chen Chenze Qi Dekun Ma | 2021 | Nano Research2021，14，10： | 1 |
| 5 | Jacobson Radicals of WAW- categories 显示文摘 | Chen Peici Wang Quanlong | 2002 | Southeast Asian Bulletin of Mathematics2002，26，： | 1 |
| 6 | A Construction Method of Online Course Portrait Based on Feature Engineering显示文摘With the emergence of massive online courses,how to evaluate the quality of courses with different qualities to improve the discrimination between courses and recommend personalized online course learning resources for learners needs to be evaluated from all aspects.In this paper,a method of constructing an online course portrait based on feature engineering is proposed.Firstly,the framework of online course portrait is established,the related features of the portrait are extracted by feature engineering method,and then the indicator weights of the portrait are calculated by entropy weight method.Finally,experiments are designed to evaluate the performance of the algorithms,and an example of the course portrait is given. | Wuying Liu Quanlong Li Yuanlong Chen | 2021 | 计算机教育2021，，12： | 0 |
| 7 | Preliminary delivery efficiency prediction of nanotherapeutics into crucial cell populations in bone marrow niche显示文摘Several crucial stromal cell populations regulate hematopoiesis and malignant diseases in bone marrow niches.Precise regulation of these cell types can remodel niches and develop new therapeutics.Multiple nanocarriers have been developed to transport drugs into the bone marrow selectively.However,the delivery efficiency of these nanotherapeutics into crucial niche cells is still unknown,and there is no method available for predicting delivery efficiency in these cell types.Here,we constructed a three-dimensional bone marrow niche composed of three crucial cell populations:endothelial cells(ECs),mesenchymal stromal cells(MSCs),and osteoblasts(OBs).Mimetic niches were used to detect the cellular uptake of three typical drug nanocarriers into ECs/MSCs/OBs in vitro.Less than 5%of nanocarriers were taken up by three stromal cell types,and most of themwere located in the extracellular matrix.Delivery efficiency in sinusoidal ECs,arteriole ECs,MSCs,and OBs in vivo was analyzed.The correlation analysis showed that the cellular uptake of three nanocarriers in crucial cell types in vitro is positively linear correlated with its delivery efficiency in vivo.The delivery efficiency into MSCs was remarkably higher than that into ECs and OBs,no matterwhat kind of nanocarrier.The overall efficiency into sinusoidal ECswas greatly lower than that into arteriole ECs.All nanocarriers were hard to be delivered into OBs(<1%).Our findings revealed that cell tropisms of nanocarriers with different compositions and ligand attachments in vivo could be predicted via detecting their cellular uptake in bone marrow niches in vitro.This study provided the methodology for niche-directed nanotherapeutics development. | Huijuan Chen Anzhi Hu Mengdi Xiao Shiyi Hong Jing Liang Quanlong Zhang Yang Xiong Mancang Gu Chaofeng Mu | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，6： | 0 |
| 8 | Synergetic N-doped carbon with MoPd alloy for robust oxygen reduction reaction显示文摘Synergistic catalysis opens up a new venue to improve the comprehensive application of the catalyst.Herein,a composite catalyst(Mo-Pd@N-C)consisting of the N-doped carbon derived from pyrolysis of spherical polypyrrole and MoPd nanoparticles(NPs)was constructed to emphasize the strong metal-support interaction for robust oxygen reduction reaction(ORR).The enhanced anchoring between the MoPd NPs and the substrate,and the N-species formed on the carbon matrix make the Mo-Pd@N-C deliver excellent performance with a half-wave potential of 0.945 V(vs.reversible hydrogen electrode(RHE))for ORR,superior than that of commercial Pt/C(0.86 V).More importantly,it shows a negligible half-wave potential decline(<5 mV)and only~20%of mass activity(MA)attenuation after 30,000 cycles stability test,obviously better than those of Pt/C(~70%of MA attenuation and~30 mV of half-wave potential decline after only 15,000 cycles).This work highlights a novel synergistic method to prolong the life and improve the commercial prospects of the catalysts. | Chaojie Cen Wenjing Tang Tonghui Zhao Yun Song Yun Yang Quanlong Xu Wei Chen | 2023 | Nano Research2023，16，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员