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| 1 | Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats显示文摘AIM To explore the kinetic changes in plasma D (-)lactate and lipopolysaccharide ( LPS ) levels, and investigate whether D (-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/reperfusion, burn, and acute necrotizing pancreatitis (ANP).METHODS Three models were developed in rats:gut ischemia/reperfusion obtained by one hour of superior severe burn injury created by 30% of total body surface induced by continuous inverse infusion of sodium taurocholate and trypsin into main pancreatic duct.Plasma levels of D( - )-lactate in systemic circulation and LPS in portal circulation were measured by enzymaticspectrophotometric method and limulus amebocyte lysate (LAL) test kit, respectively. Tissue samples of intestine were taken for histological analysis.RESULTS One hour gut ischemia followed by reperfusion injuries resulted in a significant elevation in plasma D( - )lactate and LPS levels, and there was a significant correlation between the plasma D( - )-lactate and LPS (r =0.719, P<0.05). The plasma concentrations of D(-)lactate and LPS increased significantly at 6 h postburn,and there was also a remarkable correlation between them (r = 0.877, P < 0.01). D ( - )-lactate and LPS levels elevated significantly at 2 h after ANP, with a similar significant correlation between the two levels (r-0.798,P < 0.01 ). The desquamation of intestine villi and infiltration of inflammatory cells in the lamina propria were observed in all groups.CONCLUSION The changes of plasma D( - )-lactate levels in systemic blood paralleled with LPS levels in the portal vein blood. The measurement of plasma D (-)-lactate level may be a useful marker to assess the intestinal injury and to monitor an increase of intestinal permeability and endotoxemia following severe injuries in early stage. | Xiao-Qing Sun Xiao-Bing Fu Rong-Zhan Yi Lü Qun Deng Xiao-Guo Jian Zhi-Yong Sheng Bum Institute, 304~(th)Hospital,Beijing 100037,China Department of General Surgery,Chinese PLA 304 Hospital,Beijing 100037,China | 2001 | World Journal of Gastroenterology2001，7，4： | 56 |
| 2 | Effect of slow cooling treatment on hot deformation behavior of GH4742 superalloy显示文摘 | Lü Xu-dong DENG Qun DU Jin-hui ZHONG Zeng-yong | | 0，，1： | 1 |
| 3 | A 270-GHz Tunner-Less Heterostructure Barrier Varactor Frequency Tripler显示文摘 | Qun Xiao Jeffrey L Hesler Thomas W Crowe | | 0，，03： | 1 |
| 4 | Protein cyclization en-hanced thermostability and exopeptidase - resistance of green flu- orescent protein 显示文摘 | Zhao Z L Ma X Xu Ming -Qun | 2010 | J Microbiol Biotech2010，20，3： | 1 |
| 5 | A novel conditional cell transmission model tbr oversaturated arterials 显示文摘 | WANG Ping JONES L S Qun Yang | 2012 | Journal of Central South University2012，19，14： | 1 |
| 6 | Potentiation of dexamethasone,Paclitaxel, and AD-p53-induced apoptosis by bcl-2 antisense oligedeoxynucleotides In drug-resistant multiple myeloma cells显示文摘 | Qun L Yair G | 2003 | Blood2003，101，10： | 1 |
| 7 | An Efficient and Regiospecific Strategy to N7-Substituted Purines and Its Application to a Library of Trisubstituted Purines显示文摘 | Jinglin L Qun D | 2006 | J Comb Chem2006，8，： | 1 |
| 8 | The presenting manifestations of subcutaneous panniculitis-like T-cell lymphoma and T-cell lymphoma and cutaneous γδ T-cell lymphoma may mimic those of rheumatic diseases:a report of 11cases显示文摘 | Yi L Qun S Wenjie Z | 2013 | Clin Rheumatol2013，32，8： | 1 |
| 9 | A 270-GHz tuner-less heterostructure barrier varactor frequency tripler显示文摘 | QUN Xiao HESLER J L CROWE T W | 2007 | IEEE Microwave and Wireless Components Letters2007，17，4： | 1 |
| 10 | The research on the anti - inflammatory activity and hepatotoxicity of triptolide - loaded solid lipid nanopartiele 显示文摘 | ZHI Nan M XIAO K L QUN R W | 2005 | Pharmacological Research2005，51，： | 1 |
| 11 | Political skill supervisor-subordinateGuanxi and career prospects in Chinese firms 显示文摘 | Li Qun W Jun L | 2010 | Journal ofManagement Studies2010，47，3： | 1 |
| 12 | The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression显示文摘 | Qun P Xiaoping L Tannaz T | 2007 | Mol Hum Reprod2007，13，11： | 1 |
| 13 | Impairment of T and B cell development by treatment with a type-Ⅰ interferon显示文摘 | Qun L Chen D Max DC | 1998 | J Exp Med1998，187，1： | 1 |
| 14 | An optimization frame- work for product design显示文摘 | SHI L Y OLAFSSON S QUN C | 2000 | Discrete Event Dynamic System: Theory and Application2000，10，3： | 1 |
| 15 | Uptake and distribution of N,P and heavy metals in three dominant salt marsh macrophytes from Yangtze River estuary 显示文摘 | QUN W M HAN J D SHEN A L | 2007 | China Marine Environmental Research2007，64，1： | 1 |
| 16 | Cardiac overexpression of metallothionein res- cues chronic alcohol intake - induced cardiomyocyte dysfunction: role of AKT, mammalian target of rapamycin and ribosomal P70S 6 kinase 显示文摘 | Qun L Jun R | 2006 | Alcohol&Alcoholism2006，41，6： | 1 |
| 17 | Diode-pumped CW and quasi-CW Nd : GGG(Ca, Mg, Zr) laser显示文摘 | BRUNO L WU Qun PIERRE G | 1998 | SPIE1998，2041，： | 1 |
| 18 | Prognostic role of myeloid cell leukemia-1 protein (Mcl-1) expression in human gastric cancer显示文摘 | LIKUI W QUN L WANQING Z | | 0，，05： | 1 |
| 19 | Correlation of Viscosities of Pure Liquids in a Wide Temperature Range 显示文摘 | QUN F L YU C H RUI S L | 1997 | Fluid Phase Equilibria1997，140，： | 1 |
| 20 | Structural Investigation of Two Neutral Polysaccharides Isolated from Rhizome of Polygonatum Sibirieum显示文摘 | Liu L Qun D Xiao T D | 2007 | Carbohydrate Polymers2007，70，3： | 1 |
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