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| 1 | 未破裂颅内动脉瘤患者管理指南美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的这份更新版指南旨在为未破裂颅内动脉瘤患者的管理提供全面的循证建议。方法写作组采用系统文献回顾(1977年1月至2014年6月),参考同期已发表的循证指南、个人文件和专家意见来总结现有的证据,指出现有知识的差距;如果合适,则根据美国心脏协会( American Heart Association, AHA)标准做出推荐。本指南经过了包括卒中委员会领导层以及AHA科学声明监督委员会在内的广泛同行评议,然后由AHA科学咨询和协调委员会审批通过。结果本指南对未破裂颅内动脉瘤患者的医疗诊治提出了循证建议,涉及临床表现、自然史、流行病学、危险因素、筛查、诊断、影像学以及手术和血管内治疗的转归。 | B. Gregory Thompson Robert D. Brown Sepideh Amin-Hanjani Joseph P. Broderick Kevin M. Cockroft E. Sander Connolly Gary R. Duckwiler Catherine C. Harris Virginia J. Howard S. Claiborne (Clay) Johnston Philip M. Meyers Andrew Molyneux Christopher S. Ogilvy Andrew J. Ringer James Torner 肖国栋 徐加平 石际俊 尤寿江 张霞 刘慧慧 曹勇军 | 2015 | 国际脑血管病杂志2015，23，8： | 127 |
| 2 | 婴幼儿卒中的处理:来自美国心脏协会卒中委员会和青少年心血管病委员会专门写作组的科学声明显示文摘目的:本声明旨在回顾有关儿童卒中的文献,为最佳的诊断和治疗提供推荐意见,供负责诊断和治疗婴儿、儿童和青少年脑血管病的医生使用。方法:写作组成员由美国心脏协会卒中委员会科学声明监督委员会任命,由多个不同领域的专家组成。应用美国心脏协会卒中委员会的证据分级标准对每条推荐意见进行分级。在经过小组成员审查后,草稿由4位同行评议专家和卒中委员会指导委员会成员审阅,并由美国心脏协会科学咨询和协调委员会批准。我们预计该声明需在4年内进行更新。结果:为镰状细胞病、烟雾病、颈一脑动脉夹层分离和心源性栓塞引起的缺血性卒中的预防提供循证推荐,同时为出血性卒中的评价和处理提供推荐意见。提出儿童使用肝素和华法林的剂量方案。另外,还为围产期卒中和儿童脑静脉窦血栓形成的评价和处理提供推荐。 | E.Steve Roach(著) Meredith R. Golomb(著) Robert Adams(著) Jose Biller(著) Stephen Daniels(著) Gabrielle deVeber(著) Donna Ferriero(著) Blaise V. Jones(著) Fenella J. Kirkham(著) R. Michael Scott(著) Edward R. Smith(著) 刘丽芳(译) 王胜男(译) 王伟(译) 林镇洲(译) 朱佳佳(译) 潘速跃(译) | 2008 | 国际脑血管病杂志2008，16，11： | 60 |
| 3 | 缺血性卒中的一级预防——美国心脏协会/美国卒中协会卒中委员会指南 动脉粥样硬化性周围血管病跨学科工作组、心血管护理委员会、临床心脏病学委员会、营养、体力活动和代谢委员会以及医疗质量和转归研究跨学科工作组共同倡导显示文摘背景和目的本指南提供有关各种确定和潜在的卒中危险因素证据的概述,并提供降低卒中风险的推荐。方法写作组成员由委员会主席根据每位作者先前在相关课题领域中的工作提名,并经美国心脏协会(AHA)卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾(涵盖时间段为2001年最后一次回顾发表到2005年1月),参考先前已发表的指南、个人文件和专家意见来概括现有的证据,指明现有知识的差距;如果合适,则根据标准的AHA标准做出简明的推荐。写作组全体成员在撰写过程中均有很多机会对推荐进行评论并认可这份声明的最终版本。在AHA科学咨询与协调委员会批准之前,本指南已进行过广泛的同行评议。结果对评价个体首次卒中风险的流程图进行评估。根据干预的可能性(不可干预、可干预或潜在可干预)和证据的强度(证据充分或证据不太充分),对首次卒中的危险因素或风险标记物进行分类。不可干预的危险因素包括年龄、性别、出生体重低、人种/种族和遗传因素。证据充分的可干预危险因素包括高血压、主动或被动吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、缺乏体力活动、肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白(a)升高、脂蛋白相关的磷脂酶升高、高凝状态、炎症和感染。对应用阿司匹林进行卒中一级预防的资料进行回顾。结论有大量证据可以用于确定增加首次卒中风险的各种特殊因素和提供降低这种风险的策略。 | Larry B. Goldstein Robert Adams Mark J. Alberts Lawrence J. Appel Lawrence M. Brass Cheryl D. Bushnell Antonio Culebras Thomas J. DeGraba Philip B. Gorelick John R. Guyton Robert G. Hart George Howard Margaret Kelly-Hayes J.V. (Ian) Nixon Ralph L. Sacco 苏克江 高宗恩 | 2006 | 国际脑血管病杂志2006，14，8： | 28 |
| 4 | Reversible Middle Cerebral Artery Occlusion Without Craniectomy in Rats显示文摘 | Enrique Zea Longa Philip R. Weinstein Sara Carlson Robert Cummins | 1989 | Stroke1989，，1： | 27 |
| 5 | Total hip arthroplasty for posttraumatic osteoarthritis following acetabular fracture: A systematic review of characteristics, outcomes, and complications显示文摘 | Robert D. Stibolt Jr. Harshadkumar A. Patel Samuel R. Huntley Eva J. Lehtonen Ashish B. Shah Sameer M. Naranje | 2018 | Chinese Journal of Traumatology2018，21，3： | 28 |
| 6 | Solution processed MoS2-PVA composite for subbandgap mode-locking of a wideband tunable ultrafast Er:fiber laser显示文摘我们制作自立的很少层铝二硫化物(瞬间 < 潜水艇 class= “ a-plus-plus ” > 由化学上太古的 MoS2 晶体和使用的液体阶段脱落合成的 2 )-polymer 这表明一条宽带悦耳, ultrafast 锁模式的纤维激光。稳定,微微秒脉搏,从 1,535 nm 悦耳到 1,565 nm,被产生,相应于在瞬间下面的光子精力 < 潜水艇 class= “ a-plus-plus ” > 2 材料 bandgap。这些结果贡献学习转变金属 dichalcogenides 的非线性的光性质的工作的成长身体为 ultrafast photonic 应用的现在的新机会。 | Meng Zhang Richard C. T. Howe Robert I. Woodward Edmund J. R. Kelleher Felice Torrisi Guohua Hu Sergei V. Popov J. Roy Taylor Tawfique Hasan | 2015 | Nano Research2015，8，5： | 13 |
| 7 | Insect Cell Culture and Biotechnology显示文摘The continued development of new cell culture technology is essential for the future growth and application of insect cell and baculovirus biotechnology. The use of cell lines for academic research and for commercial applications is currently dominated by two cell lines; the Spodoptera frugiperda line, SF21 (and its clonal isolate, SF9), and the Trichoplusia ni line, BTI 5B1-4, commercially known as High Five cells. The long perceived prediction that the immense potential application of the baculovirus-insect cell system, as a tool in cell and molecular biology, agriculture, and animal health, has been achieved. The versatility and recent applications of this popular expression system has been demonstrated by both academia and industry and it is clear that this cell-based system has been widely accepted for biotechnological applications. Numerous small to midsize startup biotechnology companies in North America and the Europe are currently using the baculovirus-insect cell technology to produce custom recombinant proteins for research and commercial applications. The recent breakthroughs using the baculovirus-insect cell-based system for the development of several commercial products that will impact animal and human health will further enhance interest in this technology by pharma. Clearly, future progress in novel cell and engineering advances will lead to fundamental scientific discoveries and serve to enhance the utility and applications of this baculovirus-insect cell system. | Robert R. Granados Guoxun Li G. W. Blissard | 2007 | 中国病毒学2007，22，2： | 12 |
| 8 | 卒中一级预防指南 美国心脏协会/美国卒中协会为医疗卫生专业人员制定的指南美国神经病学学会肯定本指南作为神经科医生继续教育工具的价值显示文摘背景和目的本指南对各种已确定和新出现的卒中危险因素的证据进行概述,以提供降低首次卒中风险的循证推荐。方法写作组成员由委员会主席根据每位成员先前在相关课题领域中的工作提名,并经美国心脏协会(American HeartAssociation,AHA)卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾的方法(涵盖时间为2006年上一次回顾发表到2009年4月),参考先前已发表的指南、个人文件和专家意见来总结现有证据,并指出现有知识的差距;如果合适,则根据标准的AHA标准做出推荐。写作组全体成员均有机会对推荐进行评论并审核这份声明的最终文本。在AHA科学咨询和协调委员会考察和批准之前,本指南已南卒中委员会领导层和AIIA科学声明督察委员会进行过广泛的同行评议。结果对评价个体首次卒巾风险的流程图进行了评价。根据干预的町能性(不可于预、可于预或潜在可干预)和证据的强度(证据充分或证据不太充分),对首次卒中的危险因素或风险标记物进行分类。不可干预危险因素包括年龄、性别、低出生体质量、人种/种族和遗传倾向。证据充分的叮干预危险因素包括高血压、吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、体力活动过少以及肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白(a)升高、高凝状态、炎症和感染。对用阿司匹林进行卒中一级预防的资料进行了回顾。结论多方面的证据可用于确定能增高首次卒中风险的多种具体因素并提供降低这种风险的策略。 | Larry B. Goldstein Cheryl D. Bushnell Robert J. Adams Lawrence J. Appel Lynne T. Braun Seemant Chaturvedi Mark A. Creager Antonio Culebras Robert H. Eckel Robert G. Hart Judith A. Hinchey Virginia J. Howard Edward C. Jauch Steven R. Levine James F. Meschia Wesley S. Moore J.V. (Ian) Nixon Thomas A. Pearson 张霞(译) 尤寿江(译) 陈孝东(译) 卢涛声(译) 石际俊(译) 曹勇军(译) 徐兴顺(译) | 2010 | 国际脑血管病杂志2010，18，12： | 12 |
| 9 | Functional Interaction of the SNARE Protein NtSyp121 in Ca^2+ Channel Gating, Ca^2+ Transientsand ABA Signalling of Stomatal Guard Cells显示文摘有特别圈套的总科,膜泡 trafficking 蛋白质为在植物的细胞的发信号是批评的现在成长证据。从这个实验室的工作首先表明了那一可溶,禁止(主导否定) SNARE NtSyp121 的碎片堵住了 K+ 和 Cl 隧道回答到压力相关的荷尔蒙 abscisic 酸(骆驼毛的织物) ,但是在信号中介上关于功能的影响未解决一个问题,特别在调停 Ca2+ 的发信号的事件上。这里,我们报导为 SNARE 的行动的一个模式在 Ca2+ 隧道 gating 和它的作为结果的效果通过改变直接调停了在上 cytosolic 免费[Ca2+]([Ca2+] 我) 举起。我们发现表示 NtSyp121 的一样的禁止的碎片堵住唤起骆驼毛的织物的有气孔的闭合,但是仅仅部分面对 NO 压制有气孔的闭合施主,厉声说,它支持[Ca2+] i 举起独立于血浆膜 Ca2+ 隧道。与这些观察一致,在血浆膜的Ca2+隧道 gating 被 SNARE 碎片以在为触发上升在减少潜力有效的一种方式改变[Ca2+]我,并且我们直接证明它在 vivo 的表示导致显著抑制唤起[Ca2+] i transients 。这些观察为在植物房间血浆膜的与Ca2+隧道的 SNARE 的功能的联合提供主要证据并且,因为[Ca2+]我在警卫房间在K+和 Cl 隧道水流的控制起一个关键作用,他们在有气孔的闭合期间与离子隧道规定为圈套集成强调重要机制。 | Sergei Sokolovski Adrian Hills Robert A. Gay Michael R. Blatt | 2008 | Molecular Plant2008，1，2： | 11 |
| 10 | Technical and conceptual considerations forusing animated stimuli in studies of animalbehavior显示文摘Rapid technical advances in the field of computeropened new avenues in animal behavior research.animation (CA) and virtual reality (VR) haveAnimated stimuli are powerful tools as theyoffer standardization, repeatability, and complete control over the stimulus presented, thereby"reducing" and "replacing" the animals used, and "refining" the experimental design in line withthe 3Rs. However, appropriate use of these technologies raises conceptual and technical questions.In this review, we offer guidelines for common technical and conceptual considerations related tothe use of animated stimuli in animal behavior research. Following the steps required to create ananimated stimulus, we discuss (I) the creation, (11) the presentation, and (111) the validation of CAsand VRs. Although our review is geared toward computer-graphically designed stimuli, consider-ations on presentation and validation also apply to video playbacks. CA and VR allow both new be-havioral questions to be addressed and existing questions to be addressed in new ways, thus weexpect a rich future for these methods in both ultimate and proximate studies of animal behavior. | Laura CHOUINARD-THULY Stefanie GIERSZEWSKI Gil G. ROSENTHAL Simon M. READER Guillaume RIEUCAU Kevin L. Woo Robert GERLAI Cynthia TEDORE Spencer J. INGLEY John R. STOWERS Joachim G.FROMMENI Francine L. DOLINS Klaudia WITTE | 2017 | Current Zoology2017，63，1： | 10 |
| 11 | Reversible Middle Cerebral Artery Occlusion Without Craniectomy in Rats显示文摘 | Enrique Zea Longa Philip R. Weinstein Sara Carlson Robert Cummins | 1989 | Stroke1989，，1： | 9 |
| 12 | Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology显示文摘 | Bernard Levin David A. Lieberman Beth McFarland Kimberly S. Andrews Durado Brooks John Bond Chiranjeev Dash Francis M. Giardiello Seth Glick David Johnson C. Daniel Johnson Theodore R. Levin Perry J. Pickhardt Douglas K. Rex Robert A. Smith Alan Thorson S | 2008 | Gastroenterology2008，，5： | 8 |
| 13 | Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease显示文摘 | Sunder Mudaliar Robert R. Henry Arun J. Sanyal Linda Morrow Hanns-Ulrich Marschall Mark Kipnes Luciano Adorini Cathi I. Sciacca Paul Clopton Erin Castelloe Paul Dillon Mark Pruzanski David Shapiro | 2013 | Gastroenterology2013，，： | 7 |
| 14 | Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement显示文摘 | Scott M. Grundy James I. Cleeman Stephen R. Daniels Karen A. Donato Robert H. Eckel Barry A. Franklin David J. Gordon Ronald M. Krauss Peter J. Savage Sidney C. Smith John A. Spertus Fernando Costa | 2005 | Circulation2005，，17： | 7 |
| 15 | Construction and characteristics of a transformed lepidopteran cell clone expressing baculovirus p35显示文摘A transformed cell line was constructed fromMythimna separata cells Ms7311 by lipofection methodTMs7311 cells were generated using a double selection tech-nique involving a selection in the antibiotic Zeocin, followedby a second round of selection by exhibiting cell characteri-zation. A cell clone expressing p35 was obtained with highlevel of AcMNPV and recombinant proteins. Compared withwild type Ms7311 cells, the cell clone showed increased resis-tance to Actinamycin D-induced apoptosis and a profoundresistance to nutrient development (PBS). When the cellclone was infected with recombinant baculoviruses express-ing secreted alkaline phosphatase (SEAP) and β-galactosi-dase, expression of the recombinant proteins from TMs7311cells exceeded that from parental Ms7311 cells. Production ofbudded virus and occlusion body was significantly higherthan that from parental cells Ms7311. | ZHENG Gulling LI Changyou LI Guoxun WANG Ping Robert R. Granados | 2005 | Chinese Science Bulletin2005，50，23： | 6 |
| 16 | 眼前节内眼手术应用5%吡咯烷酮碘两种不同用法的前瞻性随机化比较研究显示文摘目的:确定5%吡咯烷酮碘采用两种不同的方法(结膜囊滴两滴和10ml溶液穹窿结膜冲洗)对降低结膜囊菌群的功效。方法:在这项前瞻性对照实验中。将行眼前节手术的200只眼随机分为对照组和研究组。两组病例术前均给予氧氟沙星滴眼液局部点眼和5%吡咯烷酮碘眶周区域皮肤擦洗消毒。术前对照组眼结膜囊内给予2滴5%吡咯烷酮碘溶液,研究组眼用5%吡咯烷酮碘溶液冲洗穹窿结膜。分别于术前和术后4个时间点行结膜细菌培养。结果:研究组78只眼中20只眼(26%)术前结膜细菌培养阳性:对照组94只眼中40只眼(43%)为阳性(P=0.02)。手术结束时。研究组78只眼中14只眼(18%)、对照组94只眼中30只眼(32%)结膜细菌培养阳性(PP=0.05)。结论:手术时应用5%吡咯烷酮碘溶液冲洗穹窿结膜与结膜囊仅点入两滴相比。前者显著降低了结膜细菌培养阳性率。 | Herminia Mino de Kaspar Robert T. Chang Kuldev Singh Peter R. Egbert Mark S. Blumenkranz Christopher N. Ta 董白霞(译) 马景学(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 6 |
| 17 | Risk Factors for Opportunistic Infections in Patients With Inflammatory Bowel Disease显示文摘 | Murat Toruner Edward V. Loftus W. Scott Harmsen Alan R. Zinsmeister Robert Orenstein William J. Sandborn Jean–Frederic Colombel Laurence J. Egan | 2008 | Gastroenterology2008，，4： | 6 |
| 18 | A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma显示文摘 | Gregory L. Beatty Drew A. Torigian E. Gabriela Chiorean Babak Saboury Alex Brothers Abass Alavi Andrea B. Troxel Weijing Sun Ursina R. Teitelbaum Robert H. Vonderheide Peter J. O’Dwyer | 2013 | Clinical Cancer Research2013，，22： | 6 |
| 19 | Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper显示文摘Background: The goal of this study was to compare the antagonism of elevated dietary Cu(250 mg/kg) from Cu SO4 on three different Zn sources(Zn SO4· H2O; [Zn bis(-2-hydroxy-4-(methylthio)butanoic acid)], Zn(HMTBa)2,a chelated Zn methionine hydroxy analogue; and Zn-Methionine), as measured using multiple indices of animal performance in ROSS 308 broilers.Methods: Three experiments were conducted in broiler chicks fed a semi-purified diet. Al birds were fed a Zn-deficient diet(8.5 mg/kg diet) for 1 wk, and then provided with the experimental diets for 2 wks.Results: Experiment 1 was a 2 × 2 factorial design with two levels of Cu(8 vs. 250 mg/kg diet from Cu SO4) and two Zn sources at 30 mg/kg [Zn SO4· H2 O vs. Zn(HMTBa)2]. Elevated Cu impaired growth performance only in birds fed Zn SO4.Compared to Zn SO4· H2 O, Zn(HMTBa)2improved feed intake(12 %; P < 0.001) and weight gain(12 %, P < 0.001) and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of Zn SO4· H2 O and Zn(HMTBa)2at 30, 45, 60, and 75 mg/kg diet in the presence of 250 mg/kg Cu SO4. Feed:gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. Birds fed Zn(HMTBa)2consumed more food and gained more weight compared to birds fed Zn SO4, especially at lower supplementation levels(30 and45 mg/kg; interaction P < 0,05). Experiment 3 compared two organic Zn sources(Zn(HMTBa)2vs. Zn-Methionine)at 30 mg/kg with or without 250 mg/kg Cu SO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain(P < 0.01). Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation(P < 0.01). No difference was observed between the two Zn sources.Conclusions: Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed Zn SO4· H2 O,but had less impact in birds fed Zn(HMTBa)2. No difference was observed between the two organic zinc sources.These results are consistent with the hypothesis that chelated organic Zn is better utilized than inorganic zinc in the presence of elevated Cu. | Junmei Zhao Robert B. Shirley Julia J. Dibner Karen J. Wedekind Frances Yan Paula Fisher Thomas R. Hampton Joseph L. Evans Mercedes Vazquez-Anon | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 6 |
| 20 | Guidelines for the Primary Prevention of Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Larry B. Goldstein Cheryl D. Bushnell Robert J. Adams Lawrence J. Appel Lynne T. Braun Seemant Chaturvedi Mark A. Creager Antonio Culebras Robert H. Eckel Robert G. Hart Judith A. Hinchey Virginia J. Howard Edward C. Jauch Steven R. Levine James F. Meschi | 2011 | Stroke2011，，2： | 6 |
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