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36篇 您的检索式:作者名="RAMSAY LE"
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1African origins and chronic kidney disease susceptibility in the human immunodeficiency virus era显示文摘Chronic kidney disease(CKD) is a major public health problem worldwide with the estimated incidence growing by approximately 6% annually. There are striking ethnic differences in the prevalence of CKD such that, in the United States, African Americans have the highest prevalence of CKD, four times the incidence of end stage renal disease when compared to Americans of European ancestry suggestive of genetic predisposition. Diabetes mel itus, hypertension and human immunodeficiency virus(HIV) infection are the major causes of CKD. HIV-associated nephropathy(HIVAN) is an irreversible form of CKD with considerable morbidity and mortality and is present predominantly in people of African ancestry. The APOL1 G1 and G2 alleles were more strongly associated with the risk for CKD than the previously examined MYH9 E1 risk haplotype in individuals of African ancestry. A strong association was reported in HIVAN, suggesting that 50% of African Americans with two APOL1 risk alleles, if untreated, would develop HIVAN. However these two variants are not enough to cause disease. The prevailing belief is that modifying factors or second hits(including genetic hits) underlie the pathogenesis of kidney disease. This work reviews the history of genetic susceptibility of CKD and outlines current theories regarding the role for APOL1 in CKD in the HIV era.Alex N Kasembeli Raquel Duarte Michèle Ramsay Saraladevi Naicker 2015World Journal of Nephrology2015,4,2:3
2Combined inhibi- tion of neutral endopeptidase and angiotensin - converting enzyme by samptrilant in essential hypertension 显示文摘Wallis E J Ramsay LE Hettiarachchi J 1998Clin Pharmacol Ther1998,64,4:1
3Weight reduction in a blood pressure clinic显示文摘Ramsay LE Ramsay MH Hetliarachchi J 1978Br Med J1978,2,:1
4Influence of diuretics calcium antagonists and alpha-blockers on insulin sensitive and glucose tolerance in hypertensive patients显示文摘Ramsay LE Yeo WW Jackson PR 1992J Cardiovasc Pharmacol1992,20,:1
5First-line treatment for hypertension显示文摘Jackson PR Ramsay LE 2002Eur Heart J2002,23,3:1
6Might non - pharmacological treatment disadvantage patients with hypertension 显示文摘Ramsay LE Haq IU Yeo WW 1995J Hum Hypertens1995,9,8:1
7Combined inhibition of neutral endopeptidase and angiotensin-converting enzyme by sampatrilat in essential hypertensi on显示文摘WALLIS EJ RAMSAY LE HETTIARACHCHI J 1998Clin Pharmacol Ther1998,64,4:1
8British Hgpertension Society Guidelines for Hypertension Management 1999 显示文摘Ramsay LE William B Johnson GD 1999BMJ1999,319,14:1
9Drug intolerance due to nonspecific adverse effects related to psychiatric morbidity in hypertensive patients显示文摘Davies SJ Jackson PR Ramsay LE 2003Arch Intern Med2003,163,:1
10Combined inhibition of neutral endopeptidase and angiotensin-converting enzyme by samptrilant in essential hypertension显示文摘Wallis EJ Ramsay LE Hettiarachchi J 0,,04:1
11Aspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials显示文摘Sanmuganathan PS Ghahramani P Jackson PR Wallis EJ Ramsay LE 2001Heart2001,85,3:1
12Non-pharmacological therapy of hypertension显示文摘Ramsay LE 1994Br Med Bull1994,50,:1
13Placebo controlled trial of atenolo and nifedipine and their combination显示文摘 Ramsay LE 1991BMJ1991,,:1
14Might non-pharmacological treatment disadvantage patients with hypertension显示文摘Ramsay LE Haq IU Yeo WW 1999CMAJ1999,160,9:1
15The Sheffield table for primary prevention of coronary heart disease : corrected 显示文摘Ramsay LE Haq IU Jackson PR 1996Lan- cet1996,348,9036:1
16Non-phamacological therapy of hypertension显示文摘Ramsay LE 1994Br Med Bull1994,50,:1
17Combined inhibition of neutral endopeptidase and angiotensin-converting enzyme by samptrilant in essential hypertension显示文摘Wallis EJ Ramsay LE Hettiarachchi J 1998Clin Pharmacol Ther1998,64,4:1
18Persistent dry cough with enalapril:incidence depends on method used 显示文摘Yeo WW Ramsay LE 1999J Human Hypertens1999,4,:1
19Statins for primary prevention:at what coronary risk is safety assured显示文摘Jackson PR Wallis EJ Haq IU Ramsay LE 2001Br J Clin Pharmacol2001,52,4:1
20Is 'improvement' real with per- cutaneous transluminal angioplasty in the management of renovascular hypertension? 显示文摘Brawn LA Ramsay LE 1987Lancet1987,2,8571:1
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