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| 1 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 2 | Microstructure and oxygen storage capacity of Sr-modified Pt/CeO_2-ZrO_2 catalysts | Rui Ran a,Jun Fan b,Duan Weng a,a State Key Lab of New Ceramic and Fine Processing,Department of Materials Science and Engineering,Tsinghua University,Beijing 100084,China b The Administrative Centre for China’s Agenda 21,Beijing 100038,China | 2012 | Progress in Natural Science:Materials International2012，22，1： | 5 |
| 3 | Mapping aboveground biomass and its prediction uncertainty using LiDAR and field data, accounting for tree-level allometric and LiDAR model errors显示文摘Background: The increasing availability of remotely sensed data has recently challenged the traditional way of performing forest inventories, and induced an interest in model-based inference. Like traditional design-based inference, model-based inference allows for regional estimates of totals and means, but in addition for wall-to-wall mapping of forest characteristics. Recently Light Detection and Ranging(LiDAR)-based maps of forest attributes have been developed in many countries and been well received by users due to their accurate spatial representation of forest resources. However, the correspondence between such mapping and model-based inference is seldom appreciated. In this study we applied hierarchical model-based inference to produce aboveground biomass maps as well as maps of the corresponding prediction uncertainties with the same spatial resolution. Further, an estimator of mean biomass at regional level, and its uncertainty, was developed to demonstrate how mapping and regional level assessment can be combined within the framework of model-based inference.Results: Through a new version of hierarchical model-based estimation, allowing models to be nonlinear, we accounted for uncertainties in both the individual tree-level biomass models and the models linking plot level biomass predictions with LiDAR metrics. In a 5005 km2 large study area in south-central Sweden the predicted aboveground biomass at the level of 18 m×18 m map units was found to range between 9 and 447 Mg·ha^-1. The corresponding root mean square errors ranged between 10 and 162 Mg·ha^-1. For the entire study region, the mean aboveground biomass was 55 Mg·ha^-1 and the corresponding relative root mean square error 8%. At this level 75%of the mean square error was due to the uncertainty associated with tree-level models.Conclusions: Through the proposed method it is possible to link mapping and estimation within the framework of model-based inference. Uncertainties in both tree-level biomass models and models linking plot level biomass with LiDAR data are accounted for, both for the uncertainty maps and the overall estimates. The development of hierarchical model-based inference to handle nonlinear models was an important prerequisite for the study. | Svetlana Saarela AndréWästlund Emma Holmström Alex Appiah Mensah Sören Holm Mats Nilsson Jonas Fridman Göran Ståhl | 2020 | Forest Ecosystems2020，7，3： | 3 |
| 4 | Innate immunity–the hallmark of Helicobacter pylori infection in pediatric chronic gastritis显示文摘BACKGROUND Innate immunity was found to be associated with both persistence of Helicobacter pylori(H.pylori)infection and increased risk of gastric cancer.AIM To identify the risk factors associated with H.pylori infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children.METHODS We performed a study of 155 children with digestive symptoms,who were divided into two groups according to the histopathological exam:Group 1–48 children with H.pylori-induced chronic gastritis,and Group 2–control group.RESULTS Rural area and poor living conditions were significantly associated with H.pylori chronic gastritis(P=0.0042/P<0.0001).Both positive immunoglobulin A anti H.pylori and the rapid urease test were significantly associated with H.pylori infection(P<0.0001).Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with H.pylori chronic gastritis(P=0.111/P=0.284).We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils(P=0.0225/P=0.0292).CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation. | Lorena Elena Meliț Cristina Oana Mărginean Maria Oana Săsăran Simona Mocan Dana Valentina Ghiga Alina Bogliş Carmen Duicu | 2021 | World Journal of Clinical Cases2021，9，23： | 2 |
| 5 | Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor- kappa B activation in hematopoietic progenitor cells显示文摘 | Oyama T Ran S Ishida T | 1998 | J lmmunol1998，160，： | 1 |
| 6 | Is Local Government Efficiency Measurement in Australia Adequate? An Analysis of the Evidence显示文摘 | Wondbury K Dollery B E Prasada Ran K S | 2003 | Public Productivity and Management Review2003，27，2： | 1 |
| 7 | A model for web services discovery with QoS显示文摘 | RAN S | 2003 | ACM2003，4，1： | 1 |
| 8 | A low sodium solution for gastrointestinal lavage显示文摘 | Fordt ran J S Santa Ana C A Cleveland MvB | 1990 | Gastroenterology1990，98，11： | 1 |
| 9 | Surgical management and long-term follow-up of solid pseudopapillary tumor of pancreas:a large series from a single institution显示文摘 | Cai Y Ran X Xie S | 2014 | J Gastrointest Surg2014，18，5： | 1 |
| 10 | MicroRNA-138 plays a role in hypoxic pulmonary vascular remodelling by targeting Mstl 显示文摘 | Li S Ran Y Zhang D | 2013 | Biochem J2013，452，2： | 1 |
| 11 | Functional and binding studies of the roles ofprothrombin and beta2-glycoprotein 1 in the expression of lupus anticoagulant activity 显示文摘 | Permpikul P Ran L V Rapaport S I | 1994 | Blood1994，83，10： | 1 |
| 12 | Pcroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism 显示文摘 | Ulrich S Loitsch SM Ran O | 2006 | Cancer Res2006，66，14： | 1 |
| 13 | A model for web services discovery with Qos显示文摘 | | 2003 | ACM SIGCOM Exchanges2003，4，1： | 1 |
| 14 | A new 0-1 integer programming method of feeder reconfiguration for loss minimization in distribution systems显示文摘 | Sarma N D R Prakasa Ran K S | 1995 | Electric Power System Research1995，，33： | 1 |
| 15 | Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells显示文摘 | Oyama T Ran S Ishida T | 1998 | J Immunol1998，160，3： | 1 |
| 16 | Real-time detection of intermittent misfiring in a voltage-fed PWM inverter induction-motor drive 显示文摘 | Smith K S Ran L Penman J | 1997 | IEEE Transactions on Industrial Electronics1997，44，4： | 1 |
| 17 | The feasibility of singleport laparoscopic chnlecystectomy: a pilot study of 20 cases显示文摘 | Ran P P Bhagwat S M Rane A | 2008 | HPB ( Oxford )2008，10，5： | 1 |
| 18 | Genotype patterns and characteristics of PRNP in the Korean population 显示文摘 | Moe Lee S Ran Ju Y Choi BY | 2012 | Prion2012，6，4： | 1 |
| 19 | A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula显示文摘 | Hideyuki S Lahoucine A Ran X | 2002 | Plant J2002，32，6： | 1 |
| 20 | Experimental studies of thin-ply laminated coposites显示文摘 | Sangwook S Ran Y K Kazumasa K | 2006 | Composites science and tech- nology2006，67，6： | 1 |
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