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| 1 | Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer显示文摘AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS: Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin (TMβ), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexinⅠand an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 (HSP70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratinⅠ, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ,HSP70, annexinⅠ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION: Our study not only supports the involve- ment of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ. | Ferdous Rastgar Jazii Zahra Najafi Reza Malekzadeh Thomas P Conrads Abed Ali Ziaee Christian Abnet Mansour Yazdznbod Ali Asghar Karkhane Ghasem H Salekdeh | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | Downregulation of Tropomyosin-1 in Squamous Cell Carcinoma of Esophagus, the Role of Ras Signaling and methylation显示文摘 | Maryam Zare Ferdons Rastgar J azii Zahra-Soheila Soheili eta | 2012 | Mo- lecular Carcinogenesis2012，51，： | 1 |
| 3 | Esoph- ageal cancer alters the expression of nuclear pore corn-plex binding protein Hsc70 and eIF5A-1 显示文摘 | Moghanibashi M Rastgar J R Soheili Z S | 2013 | Functional & Integrative Genomics2013，13，2： | 1 |
| 4 | A simplified purification procedure for recombinant human granulocyte macrophage-colony stimulating factor from periplasmic space of Escherichia coli显示文摘 | Rastgar Jazii F Karkhane AA Yakhchali B | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，856，12： | 1 |
| 5 | Nanostructured TiO2 films with controlled morphology synthesized in a single step process:performance of dye-sensitized solar cells and photo watersplitting显示文摘 | THIMSEN E RASTGAR N BISWAS P | | 0，，： | 1 |
| 6 | Proteomics of a new esophageal cancer cell line established from Persian patient显示文摘 | Mehdi Moghanibashi Ferdous Rastgar Jazii Zahra-Soheila Soheili Maryam Zare Aliasghar Karkhane Kazem Parivar Parisa Mohamadynejad | 2012 | Gene2012，，1： | 1 |
| 7 | THE DIET AS A RISK RACTOR IN THE ETIOLOGY OF OESOPHAGEAL CANCER IN CASPIAN LITTORAL.显示文摘Several risk factors have been nominated for theirsuspected roles in the etiology of oesophageal neopla-sia in north-east of Iran;Mazandaran Province,whichhas shown one of the highest incidence rate in theworld.However,the attention is mostly focused on therole of diet,The commonly consumed fish,meat,vege- | Abed-AliZia'ee Ferdous Rastgar Farzaneh Sabouni | 1991 | 癌变.畸变.突变1991，3，S1： | 0 |
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