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| 1 | Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients显示文摘BACKGROUND Liver cirrhosis is the late stage of hepatic fibrosis and is characterized by portal hypertension that can clinically lead to decompensation in the form of ascites,esophageal/gastric varices or encephalopathy.The most common sequelae associated with liver cirrhosis are neurologic and neuropsychiatric impairments labeled as hepatic encephalopathy(HE).Well established triggers for HE include infection,gastrointestinal bleeding,constipation,and medications.Alterations to the gut microbiome is one of the leading ammonia producers in the body,and therefore may make patients more susceptible to HE.AIM To investigate the relationship between the use of proton pump inhibitors(PPIs)and HE in patients with cirrhosis.METHODS This is a single center,retrospective analysis.Patients were included in the study with an admitting diagnosis of HE.The degree of HE was determined from subjective and objective portions of hospital admission notes using the West Haven Criteria.The primary outcome of the study was to evaluate the grade of HE in PPI users versus non-users at admission to the hospital and throughout their hospital course.Secondary outcomes included rate of infection,gastrointestinal bleeding within the last 12 mo,mean ammonia level,and model for end-stage liver disease scores at admission.RESULTS The HE grade at admission using the West Haven Criteria was 2.3 in the PPI group compared to 1.7 in the PPI nonuser group(P=0.001).The average length of hospital stay in PPI group was 8.3 d compared to 6.5 d in PPI nonusers(P=0.046).Twenty-seven(31.8%)patients in the PPI user group required an Intensive Care Unit admission during their hospital course compared to 6 in the PPI nonuser group(16.7%)(P=0.138).Finally,10(11.8%)patients in the PPI group expired during their hospital stay compared to 1 in the PPI nonuser group(2.8%)(P=0.220).CONCLUSION Chronic PPI use in cirrhotic patients is associated with significantly higher average West Haven Criteria for HE compared to patients that do not use PPIs. | Matthew Fasullo Prashanth Rau Dong-Qi Liu Erik Holzwanger Jomol P Mathew Yurima Guilarte-Walker Gyongyi Szabo | 2019 | World Journal of Hepatology2019，11，6： | 4 |
| 2 | Hyperthermia in combined treatment of cancer显示文摘 | P Wust B Hildebrandt G Sreenivasa B Rau J Gellermann H Riess R Felix PM Schlag | 2002 | Lancet Oncology2002，，8： | 2 |
| 3 | Tunneling,propping,and expropriation:Evidence from connected party transactions in Hong Kong 显示文摘 | CHEUNG Y L RAU P R STOURAITIS A | 2006 | Journal of Financial Economics2006，82，： | 1 |
| 4 | Value and the post-acquisition performance of acquiring firms显示文摘 | Rau P R Glamour T V | 1998 | Journal of Financial Economics1998，，49： | 1 |
| 5 | Tunneling, Propping, and Expropriation: Evidence from Connected' Party Transactions in Hong Kong显示文摘 | Cheung Y P R Rau A Stouraitis | 2006 | Journal of Financial Economics2006，82，： | 1 |
| 6 | Measuring Perceived Interactivity of Mobile Advertisements 显示文摘 | Gao Q Rau P L P Salvendy G | 2010 | Behaviour & Information Technology2010，，1： | 1 |
| 7 | Mercedes-Benz公司新V6直接喷射汽油机显示文摘搭载Mercedes—Benz公司M272 DE V6直接喷射汽油机的CLS 350 CGI轿车在2006年春季日内瓦国际汽车博览会上亮相。该发动机是两年前推出的新一代M272 KE V6进气道喷射汽油机技术升级版的代表机型,也是世界上首次采用压电控制油束引导燃烧过程的直接喷射汽油机,该机在更大的部分负荷范围内实现了充量分层运转,并以非常低的燃油耗而著称,同时其零部件与进气道喷射机型有很高的通用性,能在同一条制造流水线上生产。 | Lückert P | 2007 | 国外内燃机2007，39，6： | 1 |
| 8 | The Incidence and Clinical Significance of Nucleophosmin Mutations in Childhood AML 显示文摘 | Brown P Mclntyre E Rau R | 2007 | Blood2007，110，3： | 1 |
| 9 | Hastening, delaying, or averting sudden death of quantum entanglement 显示文摘 | RAU A R P ALl M ALBER G | 2008 | Europhys Lett2008，，40： | 1 |
| 10 | Quantum discord for two-qubit X states显示文摘 | M Ali A R P Rau G Alber | 2010 | Phys Rev A2010，81，04： | 1 |
| 11 | Tunneling,propping and expropriation : Evidence from connected partytransactions in Hong Kong 显示文摘 | CHEUNG Y L RAU P R STOURAITIS A | 2006 | Journal of FinancialEconomics2006，2，： | 1 |
| 12 | Tunneling, propping, and expropriation: Evidence from connected party transactions in Hong Kong 显示文摘 | Cheung Y L Rau P R Stouraitis A | 2006 | Journal of Financial Economics2006，82，： | 1 |
| 13 | Tunneling, Propping, and Expropriation: Evidence from Connected Party Transactions in Hong Kong显示文摘 | Cheung Y L P R Rau A Stouraitis | 2008 | Journal of Financial Economics2008，82，2： | 1 |
| 14 | Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients 显示文摘 | Dumont D Noben J P Raus J | 2004 | Proteomics2004，4，7： | 1 |
| 15 | Changing Name with Style: Mutual Fund Name Changes and Their Effects on Fund Flows 显示文摘 | Michael J Cooper Huseyin Gulen P Raghavendra Rau | 2005 | The Journal of Finance2005，，6： | 1 |
| 16 | Autoimmune pathogenesis of multiple sclerosis: role of autoreactive T lymphocytes and new immunotherapeutic strategies显示文摘 | Stinissen P Raus J Zhang JW | 1997 | Crit Rev Immunol1997，17，： | 1 |
| 17 | Survival times and case fafality rates of brain injured persons显示文摘 | raus J Conroy C Cox P | 1985 | J Neurosurg1985，63，4： | 1 |
| 18 | The effect of rich Webportal design and floating animations 显示文摘 | RAU P L P GAO Q LIU J | 2007 | International Journal of Interaction2007，22，3： | 1 |
| 19 | Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer:regional radiofrequency hyperthermia correlates with clinical parameters显示文摘 | Rau B Wust P Tilly W | 2000 | Int J Radiat Oncol Biol Phys2000，48，2： | 1 |
| 20 | Socioemotional wealth and IPO underpricing of family firms显示文摘 | Leitterstorf M P and Rau S B | 2014 | Strategic Management Journal2014，35，5： | 1 |
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