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| 1 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 2 | Influence of undegraded intake protein on retake,digestion,serum hormones and metabolites,and nitrogen balance in sheep显示文摘 | Swanson K C Catun J S Redmer D A | 2000 | Small Ruminant Reserch2000，35，： | 1 |
| 3 | Influence of undegraded intake protein on intake,digestion,serum hormones and metabolites,and nitrogen balance in sheep显示文摘 | Swanson K C Caton J S Redmer D A | 2000 | Small Rumin Res2000，35，： | 1 |
| 4 | Impacts of maternal selenium and nutritional level on growth, adiposity, and glucose tolerance in female offspring in sheep 显示文摘 | Vonnahme K A Luther J S Reynolds L P Hammer C J Carlson D B Redmer D A Caton J S | 2010 | Domestic Animal Endocrinology2010，39，4： | 1 |
| 5 | Thyroid hormones and cortisol concentrations in offspring are influenced by maternal supranutritional selenium and nutritional plane in sheep 显示文摘 | Vonnahme K A Neville T L Lekatz L A Reynolds L P Hammer C J Redmer D A Caton J S | 2013 | Nutrition and Metabolic Insights2013，6，4： | 1 |
| 6 | Impacts of maternal selenium supply and nutritional plane on visceral tissues and intestinal biology in 180 - day-old offspring in sheep 显示文摘 | Yuuusova R D Neville T L Vonnahme K A Hammer C J Reed J J Taylor J B Redmer D A Reynolds L P Eaton J S | 2013 | Journal of Animal Science2013，91，5： | 1 |
| 7 | Ovarian and uterine characteristics and onset of puberty in adolescent offspring: effects of maternal diet and selenium supplementation in sheep 显示文摘 | Grazul- Bilska A T Neville T L Borowczyk E Sharma A Reynolds L P Caton J S Redmer D A Vounahme K A | 2014 | Theriogeuology2014，81，7： | 1 |
| 8 | Maternal and fetal tissue selenium loads in nulliparous does fed supranutritional and excessive selenium during mid- to late pregnancy显示文摘 | Taylor J B Reynolds L P Redmer D A Caton J S | 2009 | Journal of Animal Science2009，87，5： | 1 |
| 9 | Effects of gestational plane of nutrition and selenium supplementation on mammary development and eolostrum quality in pregnant ewe lambs 显示文摘 | Swanson T J Hammer C J Luther J S Carlson D B Taylor J B Redmer D A Neville T L Reed J J Reynolds L P Caton J S Vonnahme K A | 2008 | Journal of Animal Science2008，86，9： | 1 |
| 10 | Effects of plane of nutrition and selenium supply during gestation on ewe and neonatal offspring performance, body composition, and serum selenium显示文摘 | Meyer A M Reed J J Neville T L Taylor J B Hammer C J Reynolds L P Redmer D A Vonnahme K A Caton J S | 2010 | Journal of Animal Science2010，88，5： | 1 |
| 11 | Effects of selenium supply and dietary restriction on maternal and fetal body weight, visceral organ mass and cellularity estimates, and jejunal vascularity in pregnant ewe lambs显示文摘 | Reed J J Ward M A Vonnahme K A Neville T L Julius S L Borowicz P P Taylor J B Redmer D A Grazul-Bilska A T Reynolds L P Caton J S | 2007 | Journal of Animal Science2007，85，10： | 1 |
| 12 | Effects of selenium supply and dietary restriction on maternal and fetal metabolic hormones in pregnant ewe lambs 显示文摘 | Ward M A Neville T L Reed J J Taylor J B Hallford D M Soto- Navarro S A Vonnahme K A Redmer D A Reynolds L P Caton J S | 2008 | Journal of Animal Science2008，86，5： | 1 |
| 13 | FGF2 signaling in mouse embryonic fibroblasts is crucial for self-renewal of embryonic stem cells显示文摘 | Diecke S Quiroga-Negreira A Redmer T | 2008 | Cells Tissues Organs2008，188，12： | 1 |
| 14 | Impaets of maternal selenium and nutritional level on growth, adiposity, and glucose tolerance in female offspriag in sheep 显示文摘 | Vonnahme K A Luther J S Reynolds L P Hammer C J Carlson D B Redmer D A Caton J S | 2010 | Domestic Animal Endocrinology2010，39，4： | 1 |
| 15 | Cellular proliferation and vascularization in ovine fetal ovaries: effects of undernutrition and selenium in maternal diet 显示文摘 | Grazul - Bilska A T Caton J S Arndt W Burchill K Thorson C Borowczyk E Bilski J J Redmer D A Reynolds L P Vonnahme K A | 2009 | Reproduction2009，137，4： | 1 |
| 16 | Effects of level and source of dietary selenium on maternal and fetal body weight, visceral organ mass, cellularity estimates, and jejunal vascularity in pregnant ewe Iambs 显示文摘 | Neville T L Ward M A Reed J J Soto-Navarro S A Julius S L Borowiez P P Taylor J B Redmer D A Reynolds L P Caton J S | 2008 | Journal of Animal Science2008，86，4： | 1 |
| 17 | E- cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming 显示文摘 | Redmer T Diecke S Grigoryan T | 2011 | EMBO Rep2011，12，7： | 1 |
| 18 | Expression of gap junctional connexin proteins in ovine fetal ovaries : effects of maternal diet 显示文摘 | Grazul - Bilska A T Vnnnahme K A Bilski J J Borowczyk E Soni D Mikkelson B Johnson M L Reynolds L P Redmer D A Caton J S | 2011 | Domestic Animal Endocrinology2011，41，4： | 1 |
| 19 | Development of carbo- hydrate-derived inhibitors of acid sphingomyelinase显示文摘 | ROTH A G REDMER S ARENZ C | 2010 | Bioorg Med Chem2010，18，2： | 1 |
| 20 | Influence of undegraded intake protein on intake, digestion, serum hormones and metabolites, and nitrogen balance in sheep 显示文摘 | Swanson K C Caton J S Redmer D A | 2000 | Small Ruminant Research2000，35，3： | 1 |
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