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1Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19.Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral 2021Cellular & Molecular Immunology2021,18,9:2
2Nonlinear acoustic echo cancellation based on volterra filters 显示文摘G Alexandre F Gerard L B J Regine 2003IEEE Transactions on Speech and Audio Processing2003,11,6:1
3Degradable biomaterials based on Magnesium corrosion 显示文摘Frank W Norbert H Carla V Smadar C Karl U K Regine W Frank F 2008Current Opinion in Solid State and Materials Science2008,12,56:1
4Latent heat thermal energy storage using cylindrical capsules:Numerical and experimental investigations显示文摘 SOLANKI S C SAINI J S 2006Renewable Energy2006,,31:1
5Indocyanine green enhanced subthreshold diode-laser micropulse photocoag- ulation treatment of chronic central serous chorioretinopa- thy 显示文摘Ricci F Missiroli F Regine F 2009Graefes Arch Clin Exp Ophthalmol2009,247,5:1
6显示文摘Regin A F Solanki S C Saini J S 2008Renewable and Sustain- able Energy Reviews2008,12,:1
7Combined reduced fluence photodynamic therapy and intravitreal ranibizumab for polypoidal choroidal vasculopathy 显示文摘Ricci F Calabrese A Regine F 2012Retina2012,32,:1
8Nonlinear a- coustic echo cancellation based on Volterra filters 显示文摘G Mexandre F Gerard and L B J Regine 2003IEEE Transactions on Speech and Audio Processing2003,11,6:1
9Synthesis of a nonporous polystyrene-based strong a nion-exchange packing material and its application to fast high-performance liquid chromatographe of proteins显示文摘ROUND M A REGINER F E 1988J Chromatograph A1988,443,:1
10Indocyanine green enhanced subthreshold diode-laser micropulse photocoagulation treatment of chronic central serous chorioretinopathy 显示文摘Ricci F Missiroli F Regine F 2009Graefes Arch Clin Exp Ophthalmol2009,247,:1
11Conaparative efficacy of acetazolanaide and apraclonidine in the control of intraocular pressure following phacoemulsification 显示文摘Scuderi G Regine F Perdicchi 2006Ophthalmologica2006,220,6:1
12Telomeres and telomerase: biological and clinical importance显示文摘Regine D Wolfgang F Gunther E 1997Clinc chem1997,43,:1
13Theory of strong localization effects Of light in disordered loss or gain media显示文摘REGINE F ANDREAS L JOHANN K 2006Phys Rev B2006,73,24:1
14Bioactive extracts of red seaweeds Pterocladiella capillacea and Osmundaria obtusiloba(Floridophyceae:Rhodophyta) with antioxidant and bacterial agglutination potential显示文摘Objective:To evaluate the antioxidant,antibacterial and bacterial cell agglutination activities of the hexane(Hex) and 70%ethanol(70%EtOH) extracts of two species of red seaweeds Pterocladiella capillacea(P.capillacea) and Osmundaria obtusiloba.Methods:In vitro antioxidant activity was determined by DPPH radical scavenging assay,ferric-reducing antioxidant power assay,ferrous ion chelating assay,β-carotene bleaching assay and total phenolic content quantification.Antimicrobial activity was tested using the method of disc diffusion on Mueller-Hinton medium.The ability of algal extracts to agglutinate bacterial cells was also tested.Results:The 70%EtOH extract of the two algae showed the highest values of total phenolic content compared to the Hex extract.The results of DPPH for both extracts(Hex,70%EtOH) of Osmundaria obtusiloba(43.46%and 99.47%) were higher than those of P.capillacea(33.04%and 40.81%) at a concentration of 1 000 μg/mL.As for the ferrous ion chelating,there was an opposite behavior,extracts of P.capillacea had a higher activity.The extracts showed a low ferric-reducing antioxidant power,with optical density ranging from0.054 to 0.180.Antioxidant activities of all extracts evaluated for β-carotene bleaching were above 40%.There was no antibacterial activity against bacterial strains tested.However,the extracts of both species were able to agglutinate bacterial Gram positive cells of Staphylococcus aureus and Gram negative cells of Escherichia coli,multidrug-resistant Salmonella and Vibrio harveyi.Conclusions This is the first report of the interaction between these algal extracts,rich in natural compounds with antioxidant potential,and Gram positive and Gram negative bacterial cells.Daniel Barroso de Alencar Fátima Cristiane Teles de Carvalho Rosa Helena Rebouas Daniel Rodrigues dos Santos Kelma Maria dos Santos Pires-Cavalcante Rebeca Larangeira de Lima Bárbara Mendes Baracho Rayssa Mendes Bezerra Francisco Arnaldo Viana Regine Helena Silva dos Fernandes Vieira Alexandre Holanda Sampaio Oscarina Viana de Sousa Silvana Saker-Sampaio 2016Asian Pacific Journal of Tropical Medicine2016,9,4:1
15Gamma knife radiosurgery using 90 Gy for trigeminal neuralgia显示文摘NICOL B REGINE W F COURTNEY C 2000J Neurosurg2000,93,:1
16Postoperative radiotherapy in the treatment of single metastases to the brain:a randomized trial显示文摘PATCHELL R A TIBBS P A REGINE W F 0,,:1
17Innovation of product-related services显示文摘Heiko G Regine K Elgar F Thomas F 0,,04:1
18Synthesis of anion-porous,polystyrene-based strong anion-exchange packing material and its application to fast high-performance liquid chromatography of proteins显示文摘ROUNDS M A REGINER F E 1988J Chromatogr1988,443,:1
19Nonlinear acoustic echo cancellation based on volterra filters 显示文摘G Alexandre F Gerard L B J Regine 2003IEEE Transactions on Speech and Audio Processing2003,11,6:1
20Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial显示文摘PATCHELL R A TIBBS P A REGINE W F 1998JAMA1998,280,17:1
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