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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | 查看详情显示文摘 | (O)zyürek Z Komber H Gramm S Schmaljohann D Müller A H E Voit B | | 0，，10： | 1 |
| 3 | Primary hemophagocytic lymphohistiocytosis in Turkish children显示文摘 | Gürgey A Gogüos S Ozyürek E | 2003 | Pediatr Hematol Oncol2003，20，： | 1 |
| 4 | 3D printing based on imaging data: review of medical appli- cation 显示文摘 | Rek F Mehndiratta A von Tengg Kobligk H | 2010 | Int J Comput Assist Radiol Surg2010，5，4： | 1 |
| 5 | The relationship between acid and bile reflux and symptoms in gastro-oesophageal reflux diease 显示文摘 | Marshall REK Anggiansah A Owen WA | 1997 | Gut1997，40，2： | 1 |
| 6 | Effects of chronic trimetazidine treatment on myocardial preconditioning in anesthetized rats显示文摘 | Kara AF Demiryürek S Celik A | 2006 | Fundam Clin Pharmacol2006，20，5： | 1 |
| 7 | Understanding the VOC sorption processes on fluoro alkyl substituted phthalocyanines using ATR FT-IR spectroscopy and QCM measurements显示文摘 | Harbeck S EmirikF Gürol I Gürek A G ztürk Z Z Ahsen V | 2013 | Sensors and Actuators B:Chemical2013，176，83： | 1 |
| 8 | Chemical stabilization of metals and arsenic in contaminated soils using oxides-A review显示文摘 | Komárek M Vaněk A Ettler V | 2013 | Environmental Pollution2013，172，： | 1 |
| 9 | Prognostic significance of elevated cyclooxygenase-2 expression in patients with asenocarcinoma of the esophagus显示文摘 | BUSKENS C J VAN REKS B P SIVULA A | 2002 | Gastroenterology2002，122，： | 1 |
| 10 | Human epicardialadipose tissue is asource of inflammatorymediators 显示文摘 | Mazu rek T Zhang L Za1ews k iA e t a 1 | 2003 | Circulation2003，108，20： | 1 |
| 11 | Epicardial fat thickness in stable coronary artery disease: its relationship with high - sensitive cardiac tro- ponin T and N -terminal pro- brain natriuretic peptide显示文摘 | B~rek~i A CUr M Ozaltun B | 2014 | Coron Ar- tery Dis2014，25，8： | 1 |
| 12 | Endoscopically assist-ed removal of unilateral coronoid process hyperplasia显示文摘 | Mavili E Akyürek M Kayikiogǐlu A | 1999 | Ann Plast Surg1999，42，2： | 1 |
| 13 | Instabilities of bubbles and droplets flows in magnetic fluids显示文摘 | BASHTOVOI V G KOVALEY M REKS A | 2005 | J of Magnetism and Magnetic Materials2005，289，： | 1 |
| 14 | Effects of iron deficiency versus iron deficiency anemia on brainstem auditory evoked potentials in infancy显示文摘 | Kürek(c)i AE Sarici SU Karaoglu A | | 0，，04： | 1 |
| 15 | Infective Agents i Fixed Human Cadavers:a Brief Review and Suggested Guideline显示文摘 | Demiryürek D Bayramo?lu A Usta?elebi? | 2002 | Anat Rec2002，269，4： | 1 |
| 16 | Primary hemophagocytic lymphohistiocytosis in Turkish children 显示文摘 | G u rgey A Gogu s S Ozy u rek E | 2003 | Pediatr Hematol Oncol2003，20，5： | 1 |
| 17 | Chemical stabilization of metals and arsenic in contaminated soils using oxides:a review显示文摘 | KOMREK M VANEK A | 2013 | Environmental Pollution2013，172，： | 1 |
| 18 | Controlled Heat Transfer in Two-Component Magnetofluid Systems 显示文摘 | Bashtovoi V G Pogirnitskaya S G Reks A G | 1993 | J Magn Magn Mater1993，122，13： | 1 |
| 19 | Spatial language supports spatial cognition:evidence from deaf homesigners(abstract)显示文摘 | Goldin-Meadow S Gentner D Ozyu¨rek A | 2009 | Cognitive Processing2009，10，2： | 1 |
| 20 | Electromagnetic Induction Phenomena for a Nonmagnetic Non-Eleetroconducting Solid Sphere Moving in a Magnetic Fluid 显示文摘 | Bashtovoi V G Reks A G | 1995 | J Magn Magu Mater1995，149，12： | 1 |
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