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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | High - resolution genotypie analysis of the genus Aeromonas by AFLP finger- printing 显示文摘 | GEERT H RENATA C PAUL J | 1996 | Int J Syst Bacteriol1996，，4： | 1 |
| 3 | Improved cyclopropanation activity of histidine-ligated cyto- chrome P450 enables the enantioselective formal syn- thesis of levomilnacipran 显示文摘 | WANG Z J RENATA H PECK N E | 2014 | Angewandte Chemic2014，55，26： | 1 |
| 4 | Osmotic dehydra-tion of tomato in ternary solutions:Influence of process vari-ables on mass transfer kinetics and an evaluation of the re-tention of carotenoids显示文摘 | Renata V T Alessandra F B Miriam D H | 2007 | Journal of Food Engineering2007，，82： | 1 |
| 5 | Self- Assembled Synthesis, Characterization and Antimicrobial Activity of Zinc (11) Salicylaldimine Complexes 显示文摘 | MALGORZATA T K RENATA J ELZBIETA H K | 2009 | Inorg Chim Acta2009，362，： | 1 |
| 6 | Interval-valued intuitionistic fuzzy implications construction,properties and representability显示文摘 | Renata H S Benjamin Bedregal | 2013 | Information Sciences2013，248，： | 1 |
| 7 | Photocatalytic degradation of imazethapyr herbicide at TiOJH20 interface 显示文摘 | Renata R I Mitsugu I H Takashima K | 2005 | Chemosphere2005，58，10： | 1 |
| 8 | Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients 显示文摘 | Eniko S Renata H Laszlo J | 2010 | Inflamm Res2010，59，2： | 1 |
| 9 | Optimization of the Host-plasmid Interaction in the Recombinant Escherichia coli strain Overproducing Penicillin G Acylase显示文摘 | Renata V Lenka H S Vaclav S | 2004 | Enzyme and Microbial Technology2004，35，： | 1 |
| 10 | Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients 显示文摘 | Eniko S Renata H Laszlo J | 2010 | Inflamm Res2010，59，2： | 1 |
| 11 | Evaluation of the DNA fingerprinting method AFLP as a new tool in bacterial taxonomy显示文摘 | Paul J Renata C Geert H | 1996 | Microbiology1996，142，： | 1 |
| 12 | Aromatic compounds produced by Periconia atropurpurea,an endophytic fungus associated with Xylopia aronmtica显示文摘 | HWLDER L T RENATA S GERALDO H S | 2006 | Phytochemistry2006，67，： | 1 |
| 13 | Histamine and tyramine degradation by food fermenting microorganisms 显示文摘 | Renata GL Martina H Walter PH | 1988 | In- ternational Journal of Food Microbiology1988，，39： | 1 |
| 14 | Patient-Specific Radiation Dosimetry of ^sup 99m^Tc-HYNIC-TyF^sup 3^-Octreotide in Neuroendocrine Tumors显示文摘 | Grimes Joshua Celler Anna Birkenfeld Bozena Shcherbinin Sergey Listewnik Maria H Piwowarska-Bilska Hanna Mikolajczak Renata Zorga Piotr | 2011 | The Journal of Nuclear Medicine2011，，： | 1 |
| 15 | Analytical derivatization-a tool for determination of orotic acid 显示文摘 | Renata H Petr B Lubomir C | 2004 | J Chromatogr B2004，799，： | 1 |
| 16 | Cytotoxicity study of some Ti alloys used as biomaterial显示文摘 | Tatiani A G Donato Luciano H de Almeida Renata A Nogueira | 2009 | Materials Science and Engi- neering C2009，29，4： | 1 |
| 17 | The influence of UV-irradiation on poly(vinyl chloride)modified by poly(vinylacetate) 显示文摘 | Kaczmarek H Renata Drag Ma Gorzata | 2002 | Surface Science2002，507，： | 1 |
| 18 | Influence of emulsion composition and inlet air temperature on the microencapsulation of flaxseed oil by spray drying 显示文摘 | Renata V T Carlos R F G Miriam D H | 2011 | Food Research International2011，44，： | 1 |
| 19 | Commensal bacteria(normal microflora) ,mucosal immunity and chronic inflammatory and autoimmune diseases显示文摘 | Helena T H Renata S Tomas H | 2004 | lmmunology Letters2004，93，： | 1 |
| 20 | Influence of emulsion composition and inlet air temperature on the microencapsulation of flaxseed oil by spray drying显示文摘 | Renata V T Carlos R F G Miriam D H | 2011 | Food Research International2011，44，1： | 1 |
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