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| 1 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Partial discharge testing under direct voltage conditions显示文摘 | Renate S Johnl L | 1982 | IEEE Transactions on Aerospace and Electronic System1982，18，1： | 1 |
| 4 | Ramp technique for DC partial discharge testing显示文摘 | Renate S | 1985 | IEEE Transactions on Electrical Insulation1985，20，1： | 1 |
| 5 | Stress produced ethylene produc-tion, ethyleue binding,the response to the response to the ethyene显示文摘 | Renate M Edward C M Margrethe S | 2000 | Hort-science2000，35，2： | 1 |
| 6 | Stress induced ethylene production, ethylene binding, and the response to the ethylene action inhibitor 1-MCP in miniature roses 显示文摘 | Renate M Edward C M Margrethe S | 2000 | Scientia Horticuhurae2000，83，： | 1 |
| 7 | Characteristics of PVD coating on AZ31 hp magnesium alloys显示文摘 | Frank H Renate W Jana S | 2003 | Surface and Coatings Technology2003，162，： | 1 |
| 8 | Molecular and cellucular mechanism of joint detruction in rheumatoid arthritis, two cellular mechanisms exp lain joint destruction显示文摘 | Gay S Renate EG William J K | 1993 | Ann Rheum Dis1993，52，1： | 1 |
| 9 | Hippocampal pathology in refractory temporal lobe epilepsy显示文摘 | Regula S Renate M Samuel F | 2002 | Neurology2002，58，： | 1 |
| 10 | Characteristics of PVD-coatings on AZ31HP magnesium alloys显示文摘 | Frank H Renate W Jana S | 2003 | Surf Coat Techn2003，162，： | 1 |
| 11 | Natural gas conversion in monolithic catalysts:Interaction of chemical reactions and transport phenomena显示文摘 | Olaf D Renate S Luba I M | 2001 | Studies in Surface Science and Catalysis2001，136，2： | 1 |
| 12 | Stress induced ethylene production, ethylene binding,and the response to the ethylene action inhibitor 1-MCP in miniature roses显示文摘 | Renate M Edward C M Margrethe S | 2000 | Scientia horticulturae2000，83，： | 1 |
| 13 | Characteristics of PVD-coatings on AZ31hp magnesium alloys显示文摘 | FRANK H RENATE W JANA S | 2003 | Surface and Coatings Technology2003，162，23： | 1 |
| 14 | A practical synthesis of betulinic acid显示文摘 | RENE C KIANGA S RENATE S | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 15 | Effects of nimodipirie and other calcium channel antagonists in alco hol-preferring AA rats 显示文摘 | REND D B RENATE S ANGELIKA K | 1996 | Alcohol1996，13，3： | 1 |
| 16 | Molecular and cellular mechanis of joint destruction in rheumatoid arthritis; two cellular mechanis explain joint destruction显示文摘 | Gays S renate EG William JK | 1993 | Ann Rherm Dis1993，，： | 1 |
| 17 | Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B显示文摘 | Renate G Vander M Dave S | 2004 | Hepatology2004，40，7： | 1 |
| 18 | Chemotaxis-guided movements in Bacteria 显示文摘 | Renate L Wenyuan S | 2004 | Crit Rev Oral Biol Med2004，15，4： | 1 |
| 19 | Work loss following stroke显示文摘 | Gabriele W Renate S | 2009 | Disability & Re-habilitation2009，31，14： | 1 |
| 20 | Changes in globus pallidus with (Pre) term kernicterus 显示文摘 | Paul G Maarten L Renate S | 2003 | Pediatrics2003，112，： | 1 |
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