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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Replacements of juvenile manne shrimp,Penaeus monodon (Fabricius)for lysine and arginine显示文摘 | Millamena O M Baufista-Teruel M N Reyes O S | 1998 | Aquac1998，164，： | 1 |
| 3 | Rat Strains Differ in Susceptibility to Urinary Tract Infection and Struvite Ureaplasma parvum-Induced Urinary Tract Infection and Struvite Stone Formation显示文摘 | Reyes L Reinhard M O'Donell LJ | 2006 | Infection and immunity2006，74，12： | 1 |
| 4 | Identification of single a-mino acid residues essential for the binding of lipopolysaccharide(LPS)to LPS binding protein(LBP)residues 86-99 by using anAla-scanning library显示文摘 | Reyes O Vallespi MG Garay HE | 2002 | J Pept Sci2002，8，4： | 1 |
| 5 | Spanish muhicenter taflu- prost tolerability study 显示文摘 | M1LLA E STIRBU O REY A | 2012 | Br J Ophthalmol2012，96，6： | 1 |
| 6 | Comparative study of the expression of metalloproteases and their inhibitors in different localizations within primary tumours and in metastatic lymph nodes of breast cancer显示文摘 | GARCA M F GONZ(A)LEZ REYES S GONZLEZ L O | 2010 | Int J Exp Pathol2010，91，4： | 1 |
| 7 | CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphoryla- tion and exhibits anticancer properties both in vitro and in vi- vo显示文摘 | PEREA S E REYES O BALADRON I | 2008 | Mol Cell Bioehem2008，316，12： | 1 |
| 8 | Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor 显示文摘 | Reyes H Reisz-Porszasz S Hankinson O | 1992 | Science1992，256，5060： | 1 |
| 9 | Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events显示文摘 | GONZLEZ L O GONZLEZ REYES S JUNQUERA S | 2010 | J Cancer Res Clin Oncol2010，136，9： | 1 |
| 10 | Ocean acidification and warming scenarios increase microbioerosion of coral skeletons显示文摘 | REYES Nivia C DIAZ Pulido G KLINE D GULDBERG O H DOVE S | 2013 | Global Change Biology2013，19，6： | 1 |
| 11 | Density-functional calculations of the structures, binding energies, and magnetic moments of Fe clusters with 2 to 17 atoms显示文摘 | Di e guez O Alemany M M G Rey C | 2001 | Phys Rev B2001，63，： | 1 |
| 12 | Sensory and motor trigeminal evoked potentials to localize the position of trigeminal electrodes显示文摘 | KAROL E A SANZ O P REY R D | 1991 | Acta Neurochir Wien1991，108，： | 1 |
| 13 | Heat Flow for the Equation of Surfaces with Prescribed Mean Curvature显示文摘 | Rey O | 1991 | Mathematische Annalen1991，291，1： | 1 |
| 14 | Capacity constraints, mergers and collusion显示文摘 | Compte O Jenny F Rey P | 2002 | European Economic Review2002，46，： | 1 |
| 15 | Genetic parameters for growth and reproductive traits of Can- chim breed 显示文摘 | Borba L H F Rey F S B da Silva L O C | 2011 | Pesquisa Agropecu Bras2011，46，11： | 1 |
| 16 | Immunosuppressants: neuropro- tection and promoting neurological recovery following peripheral nerve and spinal cord lesions 显示文摘 | Sosa I Reyes O Kuffler DP | 2005 | Exp Neurol2005，195，： | 1 |
| 17 | <ce:link locator='fx1'/> 13 C-Mixed Triglyceride Breath Test to Assess Oral Enzyme Substitution Therapy in Patients With Chronic Pancreatitis显示文摘 | J. Enrique Domínguez–Mu?oz Julio Iglesias–García María Vilari?o–Insua Marta Iglesias–Rey | 2007 | Clinical Gastroenterology and Hepatology2007，，4： | 1 |
| 18 | Creating and characterizing communities of human gut microbes in gnotobiotic mice显示文摘 | Faith J J Rey F E O'Donnell D | 2010 | ISME J2010，4，9： | 1 |
| 19 | Pharmacokinetics of the individual enantiomers of vigabatrin ( gamma-vinyl GABA) in epileptic children 显示文摘 | Rey E Pons G Richard M O | 1990 | Br J Clin Pharmacol1990，30，2： | 1 |
| 20 | Novel bifunctional NiMo/A1-SBA-15 catalysts for deep hydrodesulfurization: Effect of support Si/Al ratio显示文摘 | KLIMOVA T REYES J GUTIERREZ O | 2008 | Appl Catal: A2008，335，2： | 1 |
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