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| 1 | Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?显示文摘Hepatic glycogenosis(HG) is characterized by excessive glycogen accumulation in hepatocytes and represents a hepatic complication of diabetes that particularly occurs in patients with longstanding poorly controlled type 1 diabetes(T1D). HG has been reported to be a very rare disease, although it is believed to be extremely underdiagnosed because it is not possible to distinguish it from non-alcoholic fatty liver disease(NAFLD) unless a liver biopsy is performed. In contrast to HG, NAFLD is characterized by liver fat accumulation and is the more likely diagnosis for patients with type 2 diabetes and metabolic syndrome. The pathogenesis of HG involves the concomitant presence of insulin and excess glucose, which increases glycogen storage in the liver. HG is characterized by a transient elevation in liver transaminases and hepatomegaly. Differentiating between these two conditions is of the utmost importance because HG is a benign disease that is potentially reversible by improving glycemic control, whereas NAFLD can progress to cirrhosis. Therefore, HG should be suspected when liver dysfunction occurs in patients with poorly controlled T1 D. The aim of this article is to review the epidemiology, clinical characteristics, pathogenesis and histology of HG. | María Teresa Julián Núria Alonso Isabel Ojanguren Eduarda Pizarro Enric Ballestar Manel Puig-Domingo | 2015 | World Journal of Diabetes2015，6，2： | 4 |
| 2 | Identification of Lynch syndrome: How should we proceed in the 21^(st) century?显示文摘Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appearedin the last few years. | Antoni Castells Francesc Balaguer Sergi Castellví-Bel Victòria Gonzalo Teresa Ocaa | 2007 | World Journal of Gastroenterology2007，13，33： | 3 |
| 3 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 4 | Prospective study on late renal toxicity following postoperative chemoradiotherapy in gastric cancer显示文摘 | Ria PB Cats A Stroom J | 2007 | Int J Radiat Oncol Biol Phys2007，67，3： | 1 |
| 5 | Human erythropoietin induces a por-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo显示文摘 | Ribatti D Presta M Vacca A Ria A Giuliani R Dell'Era P | 1999 | Blood1999，93，： | 1 |
| 6 | A paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma显示文摘 | Vacca A Ria R Ribatti D | 2003 | Haematologica2003，88，2： | 1 |
| 7 | A paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma显示文摘 | Vacca A Ria R Ribatti D | 2003 | Haematologica2003，88，2： | 1 |
| 8 | Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells显示文摘 | Pellegrino A Ria R Di Pietro G | | 0，，： | 1 |
| 9 | Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells显示文摘 | Pellegrino A Ria R Di Pietro G | 2005 | Br J Haematol2005，129，2： | 1 |
| 10 | Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population?显示文摘 | Núria Vilarrasa Joan Vendrell Javier Maravall I?aki Elío Esther Solano Patricia San José Isabel García Núria Virgili Juan Soler José Manuel Gómez | 2010 | Endocrine2010，，2： | 1 |
| 11 | ^90Y-ibritumomab tiuxetan as con- solidation therapy after autologous stem cell transplantation in ag- gressive non-Hodgkin lymphoma显示文摘 | Ria R Musto P Reale A | 2011 | J Nuel Med2011，52，6： | 1 |
| 12 | A paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma显示文摘 | VACCA A RIA R RIBATTI D | 2003 | Haematologica2003，88，2： | 1 |
| 13 | Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 agree with progression of ovarian endometriomas 显示文摘 | Ria R Loverro G Vacca A | 2002 | Eur J Clin Invest2002，32，3： | 1 |
| 14 | Harmful Effects of Viral Replication in Seropositive Hepatitis C Virus Renal Transplant Recipients显示文摘 | Miguel A. Gentil Govantes Núria Esforzado Josep M. Cruzado Francisco M. González- Roncero Montserrat Bala?a Núria Saval José M. Morales | 2012 | Transplantation Journal2012，，11： | 1 |
| 15 | A paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma显示文摘 | Vacca A Ria R Ribatti D | 2003 | Haematologica2003，88，2： | 1 |
| 16 | Antioxidant enzymes responses to cadmium in radish tissues显示文摘 | Vitó ria A P Lea P J Azevedo R A | 2001 | Phytochemistry2001，57，： | 1 |
| 17 | Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 agree with progression of ovarian endometriomas显示文摘 | Ria R Loverro G Vacca A | 2002 | Eur J Clin Invest2002，32，3： | 1 |
| 18 | Neovascularisation, expression of fibroblast growth factor-2,and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma显示文摘 | Ribatti D Vacca A Ria R | 2003 | Eur J Cancer2003，39，5： | 1 |
| 19 | De- velopment of multiresidue DLLME and QuEChERS based LC- MS/MS method for determination of selected neonicotinoid insecti- cides in honey liqueur 显示文摘 | Parle Jovanov Val e ria Guzsv a ny Mladen Franko | 2014 | Food Research International2014，55，： | 1 |
| 20 | Inheritance of long juvenile period under short day conditions in soybean显示文摘 | Valéria C P Almeida L A Kiihl R A S | 2002 | Genet Mol Biol2002，，25： | 1 |
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