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| 1 | Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging显示文摘BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. | Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein | 2019 | World Journal of Radiology2019，11，5： | 2 |
| 2 | Polyhydroxylated tri-terpenes from Eriobotrya japonica显示文摘 | Zhou Z L Rita A Vincenzo D F | 1990 | Planta Med1990，56，3： | 1 |
| 3 | Ganglion Cell Loss after Optic Crush Mediated through AMPA-Kainate and NMDA Receptors 显示文摘 | Frank S Rita N Cbristian KV David Z | 2000 | J IOVS2000，13，： | 1 |
| 4 | Unrelated helpers in a social insect 显示文摘 | David C Francesca Z Rita C | 2000 | Nature2000，405，： | 1 |
| 5 | Stabilities of divalent and triralent metal ion complexes of macrocyclic triazatrizacetic acids 显示文摘 | Rita D Sun Y Z Motekaitis R J | 1993 | Inorg Chem1993，32，： | 1 |
| 6 | Polyhydroxylated triterpenes from Eriobotrya japonica显示文摘 | Zhou Z L Rita A Vincenzo D F | 1990 | Planta Med1990，56，3： | 1 |
| 7 | Unrelated helpers in a social insect显示文摘 | David C Francesca Z Rita C | 2000 | Nature2000，405，： | 1 |
| 8 | Interferon alpha-2b for chronic hepatitis C:effects of close increment and duration of treatment on response rates results of the first multicenter Australian frial显示文摘 | Rita L Eliott R Matthew Z | 1995 | Hepatology1995，23，： | 1 |
| 9 | Grafting of cyclodextrins onto filter paper显示文摘 | RITA C DE B GISELLA M Z FLAVIO F DE M | 2007 | J Incl Phenom Macrocycl Chem2007，57，1234： | 1 |
| 10 | Polyhydroxylated triterpenes from Eriobotrya japonica显示文摘 | Zhou Z L Rita A Vincenzo D F | 1990 | Planta Med1990，56，3： | 1 |
| 11 | A Bacillus subtilis secreted protein with a role in endospore coat assembly and function显示文摘 | Monica S Rita Z O Ezio R | 1999 | Bacteriology1999，181，12： | 1 |
| 12 | Polyhydroxylated triterpenes from Eriobotrya japonica 显示文摘 | Zhou Z L Rita A Vincenzo D F etal | | Planta Medica0，56，3： | 1 |
| 13 | A Bacillus subtilis Secreted Protein with a Role in Endospore Coat Assembly and Function 显示文摘 | MONICA S RITA Z O EZIO R | 1999 | Bacteriology1999，181，12： | 1 |
| 14 | NADPH Diaphorase activity in the antennae of the hawkmoth Manduca Sexta显示文摘 | MONIKA S RITA Z | 1996 | Experimental Biology1996，199，5： | 1 |
| 15 | Cooperation of T h1 and T h17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy显示文摘 | Veronika Nindl Reinhard Maier David Ratering Rita De Giuli Roland Züst Volker Thiel Elke Scandella Franco Di Padova Manfred Kopf Markus Rudin Thomas Rülicke Burkhard Ludewig | 2012 | Immunol2012，，9： | 1 |
| 16 | Souble acid invertase determines the hexose-to-sucrose ratio in cold-stored potato tubers 显示文摘 | Rita Z Konrad S Uwe S | 1996 | Planta1996，198，： | 1 |
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