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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by leng-term in patients undergoing percutaneous coronary intervatien: the PCI-CUBE study 显示文摘 | Mehta SR Yusuf S Peters RJG | 2001 | Lancent2001，358，9281： | 1 |
| 3 | Tissue factor and coronary artery disease显示文摘 | Moons AHM Levi M Peters RJG | 2002 | Cardiovasc Res2002，53，： | 1 |
| 4 | Isolation of microsatellite DNA markers from a passerine bird, Dendroica petechia (the yellow warbler), and their use in population studies显示文摘 | Dawson RJG Gibbs HL Hobson KA | 1997 | Heredity1997，79，： | 1 |
| 5 | Incidence, prevention and treatment of pressure ulcers in intensive care patients: a longitudinal study显示文摘 | Shahin ESM Dassen T Halfens RJG | 2009 | International Journal of Nursing Stud- ies2009，46，4： | 1 |
| 6 | Textbookof contact dermatitis 显示文摘 | Rycroft RJG Menne T FroschPT | 1992 | Springer Verlag1992，602，： | 1 |
| 7 | Validity and reliability the Braden scale and the influence of risk factors:A multi-centre prospective study显示文摘 | Halfens RJG Achterberg T Bal RH | 2000 | International Journal of Nursing Studies2000，37，： | 1 |
| 8 | Chnical implications of chemotherapy-induced diarrhea显示文摘 | Arnold RJG Gabrail N Raut M | 2005 | J Support Oncol2005，3，3： | 1 |
| 9 | Grol RTPM:Prevalence,prevention and treatment of pressure ulcers:descriptive study in 89 institutions in the Netherlands显示文摘 | Bours GJJW Halfens RJG Huyer Abu-Saad H | 2002 | Research in Nursing&Health2002，25，： | 1 |
| 10 | Grol RTPM:Prevalence,prevention and treatment of pressure ulcers:descriptive study in 89 institutions in the Netherlands显示文摘 | Bours GJJW Halfens RJG Huyer Abu-Saad H | 2002 | Research in Nursing&Health2002，25，2： | 1 |
| 11 | Periapical lesions accidentally filled with calcium hydroxide显示文摘 | Moor RJG De Witte AMJ De | 2002 | Int Endod J2002，35，11： | 1 |
| 12 | Histopatholog icvalidation of intracoronary ultrasoud imaging显示文摘 | Peters RJG Kok WEM Havenith MG | 1998 | J Am Soc Echocardiogr1998，7，： | 1 |
| 13 | Periapical lesions accidentally filled with calcium hydroxide显示文摘 | Moor RJG De Witte AMJ De | 2000 | Int Endod J2000，35，11： | 1 |
| 14 | Clinical implication of chemotherapy-induced diarrhea 显示文摘 | Arnold RJG Gabrail N Raut M | 2005 | J Support Oncol2005，3，3： | 1 |
| 15 | Prevalence, risk fac- tors and prevention of pressure ulcers in Dutch intensive care units 显示文摘 | Bouts GJJW De Laat E Halfens RJG | 2001 | Intensive Care Med2001，27，10： | 1 |
| 16 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention:the PCI-CURE study显示文摘 | Mehta SR Yusuf S Peters RJG | 2001 | Lancet2001，358，： | 1 |
| 17 | Effects of pretreatment with clopidogrel and aspirin followed by long - term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study 显示文摘 | Mehta SR Yusuf S Peters RJG | 2001 | Lancet2001，358，： | 1 |
| 18 | Effects of pretreaUnent with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study 显示文摘 | Mehta SR Yusuf S Peters RJG | 2001 | Lancet2001，358，9281： | 1 |
| 19 | Persistent fatigue in liver transplant recipients: A two- year follow- up study 显示文摘 | Ginneken BTJ Berg - Emons RJG Windt AV | 2010 | Clinical Transplantation2010，24，： | 1 |
| 20 | The radix entomolaris in mandibular first molars: an endodontic challenge显示文摘 | De Moor RJG Deroose CMG Calberson FLG | 2004 | Int Endod J2004，37，11： | 1 |
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