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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 3 | Low-dose thoracoab- dominal irradiation for the treatment of refractory chronic graft- versus-host disease显示文摘 | Robin M Guardiola P Girinsky T | 2005 | Transplantation2005，80，5： | 1 |
| 4 | Management of intermittent ovarian torsion by laparoscopic oophoropexy显示文摘 | Germain M Rarick T Robins E | 1996 | Obste Gynecol1996，88，4： | 1 |
| 5 | Minimal sufficient causation and directed acyclic graphs 显示文摘 | VanderWeele T J Robins J M | 2009 | Annals of Statistics2009，37，3： | 1 |
| 6 | Specification, estimation and validation of a pedestrian walking behavior model显示文摘 | Robin T Antonini G Bierlaire M et el | 2009 | Transpor- tation Research Part 132009，43，1： | 1 |
| 7 | A 10-bit 50 MS/s pipelined ADC with capacitor-sharing and variable opamp 显示文摘 | BYUNG G L ROBIN M T | 2009 | IEEE JSSC2009，44，3： | 1 |
| 8 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 9 | Specification, estimation and validation of a pedestrian walking behavior model显示文摘 | ROBIN T ANTONINI G BIERLAIRE M | 2009 | Transportation Research Part B2009，43，1： | 1 |
| 10 | Neptunium and uranium complexation by hydroxamic acids 显示文摘 | Iain M Robin J T | 1998 | Journal of Alloys and Compounds1998，27，2： | 1 |
| 11 | Bak core and latch domains separate during activation,and freed core domains form symmetric homodimers显示文摘 | Brouwer J M Westphal D Dewson G Robin A Y Uren R T Bartolo R Thompson G V Colman P M Kluck R M Czabotar P E | 2014 | Mol Cell2014，55，6： | 1 |
| 12 | The 'Little Five' :exploring the nomological network of the Five Factor Model of personality in adolescent boys显示文摘 | John O P Caspi A Robins R W Moffitt T E Stouthamer- Loeber M | 1994 | Child Development1994，65，： | 1 |
| 13 | Tuareg,a novel miniature-inverted repeat family of pearl millet ( Pennisetum glaucum ) related to the P IF superfamily of maize显示文摘 | REMIGEREAU M S ROBIN O SILJAK-YAKOVLEV S SARR A ROBERT T LANGIN T | 2006 | Genetica2006，128，13： | 1 |
| 14 | 显示文摘 | Mathies T Robin M A | 2000 | Biological Journal of the Linnean Society2000，71，： | 1 |
| 15 | The stem cell marker CD133 associates with enhanced' colony formation and cell motility ifi colorectal cancer 显示文摘 | ELSABA T M MARTINEZ-POMARES L ROBINS A R | 2010 | PLoS One2010，5，10： | 1 |
| 16 | Molecular model of human CYP21 based on mammalian CYP2C5: structural features correlate with clinical severity of muta- tions causing congenital adrenal hyperplasia显示文摘 | Robins T Carlsson J Sunnerhagen M | 2006 | Mol Endo- crinol2006，20，： | 1 |
| 17 | The predominant role of collagen in the nucleation, growth, structure and orientation of bone apatite 显示文摘 | Wang Y Azais T Robin M | 2012 | Nat Mater2012，11，8： | 1 |
| 18 | Using granular media amendments to enhance NOM removal 显示文摘 | Robin Collins M Taylor Eighmy T | 1998 | AWWA1998，90，12： | 1 |
| 19 | Nutrient and microbial dynamics in high-intensity,zero-exchange shrimp ponds in Belize显示文摘 | Michele A B Peter J T Robins P M | 2003 | Aquaculture2003，219，： | 1 |
| 20 | The chicken type ⅢGnRH receptor homologue is predominantly expressed in the pituitary,and exhibits similar ligand selectivity to the type Ⅰ receptor显示文摘 | Nerine T J Kevin M Robin S | 2009 | Journal of Endocrinology2009，202，： | 1 |
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