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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 5 | Superior per ovskite oxide-ion conductor strontium- and magnesium-doped La GaO3 显示文摘 | HUANG Ke-qin ROBIN S T Goodenough J B | 1998 | Journal of American Cemic Soc1998，81，10： | 1 |
| 6 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 7 | Minimal sufficient causation and directed acyclic graphs 显示文摘 | VanderWeele T J Robins J M | 2009 | Annals of Statistics2009，37，3： | 1 |
| 8 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 9 | Neptunium and uranium complexation by hydroxamic acids 显示文摘 | Iain M Robin J T | 1998 | Journal of Alloys and Compounds1998，27，2： | 1 |
| 10 | Bak core and latch domains separate during activation,and freed core domains form symmetric homodimers显示文摘 | Brouwer J M Westphal D Dewson G Robin A Y Uren R T Bartolo R Thompson G V Colman P M Kluck R M Czabotar P E | 2014 | Mol Cell2014，55，6： | 1 |
| 11 | Molecular model of human CYP21 based on mammalian CYP2C5: structural features correlate with clinical severity of muta- tions causing congenital adrenal hyperplasia显示文摘 | Robins T Carlsson J Sunnerhagen M | 2006 | Mol Endo- crinol2006，20，： | 1 |
| 12 | Conserved vertebrate mir-451 provides a platform for Dicer-independent,Ago2-mediated mi- croRNA biogenesis 显示文摘 | Yang J Manrin T Robine N | 2010 | Proc Natl Acad Sci USA2010，107，15： | 1 |
| 13 | The stability of SiC coating and SiO2/SiC multilayer on the surface of graphite for HTGRs at normal service condition显示文摘 | FU Z Q LIANG T X ROBIN J C | 2005 | Applied Surface Science2005，240，14： | 1 |
| 14 | Nutrient and microbial dynamics in high-intensity,zero-exchange shrimp ponds in Belize显示文摘 | Michele A B Peter J T Robins P M | 2003 | Aquaculture2003，219，： | 1 |
| 15 | Design, synthesis and broad spectrum antiviral activity of 1-/3-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides显示文摘 | WITKOWSKI J T ROBINS R K SIDWELL R W | 1972 | J Med Chem1972，15，11： | 1 |
| 16 | The chicken type ⅢGnRH receptor homologue is predominantly expressed in the pituitary,and exhibits similar ligand selectivity to the type Ⅰ receptor显示文摘 | Nerine T J Kevin M Robin S | 2009 | Journal of Endocrinology2009，202，： | 1 |
| 17 | Synthesis of (polyethylene terephthalate/ poly e-caprolactone) copolyesters显示文摘 | Saint-Loup R Jeanmaire T Robin J | 2003 | Polymer2003，44，12： | 1 |
| 18 | Relation of gemfibrozil treatmenttreatmentand lipid levels with major coronary events:VA-HIT:a randomized controlled trial显示文摘 | Robins S J Collins D Wittes J T | 2001 | JAMA2001，285，： | 1 |
| 19 | Effective targeting of lipesomes to liver and hepatocytes in vivo by incorporation of a plasmodium amino acid sequence显示文摘 | KENNETH J LONGMUIR RICHARD T ROBiN SHERRY M HAYNES | 2006 | Pharmaceutical Research2006，23，： | 1 |
| 20 | Anti-myelin basic protein antibodyin experimental allergic optic neuritis and encephalomyelitis显示文摘 | Robin J B Phillips T M Rao N A | 1985 | Oph-thalmic Res1985，17，： | 1 |
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