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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Unidimensional heat transfer analysis of elephant grass and sugar cane bagasse slow pyrolysis in a fixed bed reactor显示文摘 | Mesa-Perez J M Cortez L A B Rocha J D | 2005 | Fuel Processing Technology2005，86，5： | 1 |
| 3 | Unidimensional heat transfer analysis of elephant grass and sugar cane bagasse slow pyrolysis in a fixed bed reactor显示文摘 | L A B Cortez J D Rocha | 2005 | Fuel Processing Technology2005，86，： | 1 |
| 4 | Speciation of mercury using capillary electrophoresis coupled to volatile species generation-inductively coupled plasma mass spectrometry 显示文摘 | ROCHA M S SOLDADO A B BLANCO E | 2001 | J Anal At Spectom2001，，16： | 1 |
| 5 | A comparative study of the toxicity of a synthetic surfactant and one produces by Pseudomonas aeruginosa ATCC 55925 显示文摘 | Flasz A Rocha C A Mosquera B | 1998 | Medical Science Research1998，26，3： | 1 |
| 6 | Graphene for toughand electroconductive alumina ceramics 显示文摘 | CENTENO A ROCHA V G ALONSO B | 2013 | J Eur Ceram Soc2013，33，32： | 1 |
| 7 | Phylogeography of the trumpetfishes (Aulostomus) :Ring species complex on a globa scale显示文摘 | Bowen B W Bass A L Rocha L A | 2001 | Evolution2001，55，5： | 1 |
| 8 | Serum Hsp70 as an ealry perdictor of fatal outcome after severe traumatic brain injury in males显示文摘 | da Rocha A B Zanoni C de Freitas G R | 2005 | J Neuortrauma2005，22，9： | 1 |
| 9 | Woodss-A spatial decision support system based on workflows显示文摘 | Seffino L A Medeiros C B Rocha J | 1999 | The Establishment of Decision Support System1999，，27： | 1 |
| 10 | 17 Beta-estra- diol-induced antidepressant-like effect in the forced swim test is ab- sent in estrogen receptor-beta knockout (BERKO) mice显示文摘 | ROCHA B A FLEISCHER R SCHAEFFER J M | 2005 | Psycho- pharmacology ( Berl )2005，179，3： | 1 |
| 11 | Role of mast cells and pro-inflammatory mediators on the intestinal secretion induced by cholera toxin显示文摘 | Marcos F.G Rocha José E.P Aguiar José J.C Sidrim Raimundo B Costa Regina F.G Feitosa Ronaldo A Ribeiro Aldo A.M Lima | 2003 | Toxicon2003，，2： | 1 |
| 12 | lnfluence of chemical treatment on quality of cut apple( cv Jonagored) 显示文摘 | Rocha A M C N Brochado C M Morais A M M B | 1998 | Food Qual1998，21，： | 1 |
| 13 | Photosynthetic and water use efficiency responses to diffuse radiation by an aspen-dominated northern hardwood forest 显示文摘 | Rocha A V Su H B Vogel C S | 2004 | Forest Science2004，50，： | 1 |
| 14 | Single photon detector fabricated in a complementary metal-oxide- semiconductor high-voltage technology显示文摘 | Rochas A Gani M Furrer B | 2003 | Review of Scientific2003，74，7： | 1 |
| 15 | Toxicity of some glucose/mannose-binding lectins to Biomphalaria glabrata and Artemia salina显示文摘 | SANTOS A F D CAVADA B S ROCHA B A M D | 2010 | Bioresource Technology2010，101，2： | 1 |
| 16 | Comparing ethylene glycol with glycerol for cryopreservation of canine semen in egg-yolk TRIS extenders显示文摘 | Martins B A Rocha A Mayenco A A | 2006 | Theriogenology2006，66，9： | 1 |
| 17 | IL-1β and IL-1RN polymorphic genes and Helicobacter pylori cagA strains decrease the risk of reflux esophagitis显示文摘 | Queiroz D M Guerra J B Rocha G A | 2004 | Gastroenterology2004，127，1： | 1 |
| 18 | The market value of forest concessions in the Brazilian Amazon: a real op- tion approach 显示文摘 | ROCHA K MOREIRA A R B REIS E J | 2006 | Forest Policy and Economics2006，，8： | 1 |
| 19 | Copper recovery and cyanide oxidation by electrowinning from a spent copper-cyanide electroplating electrolyte显示文摘 | DUTRA A J B ROCHA G P POMBO F R | 2008 | Journal of Hazardous Materials2008，152，： | 1 |
| 20 | Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance显示文摘 | Rocha B Gromdien A Treita AA | 1995 | J Exp Med1995，181，3： | 1 |
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