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| 1 | Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients显示文摘AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation. | A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ML Bacchi-Reggiani E Roda D Festi | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 2 | Development and validation of a sensitive HPLC-ES1-MS/MS method for the direct determination of glucosanline in human plasma显示文摘 | Roda A Sabatini L Barbieri A | 2006 | J Chromatogr B Anglyt Technol Biomed Life Sci2006，844，1： | 1 |
| 3 | Comparison of biota sample pretreatments for arsenic speciation with coupled HPLC-HG-ICP-MS显示文摘 | ARIZA J L G RODAS D S GIRALDEZ I | 2000 | Analyst2000，125，： | 1 |
| 4 | Heart -rate variability and precompetitive anxiety in swimmers 显示文摘 | Cervantes Blasquez J C Rodas Font G Capdevila Ortis L | 2009 | Psicothema2009，21，4： | 1 |
| 5 | High frequency rail- way vehicle-track dynamics through flexible rotating wheelsets 显示文摘 | Baeza L Fayos J Roda A | | Vehicle System Dynamics0，46，7： | 1 |
| 6 | Thermogravimetric studies on the effect of support in sorbent-materials applied to flue gas desulfurization 显示文摘 | FLORES R RODAS A PALMA C MELENDEZ Y 1 MELENDEZ X S GONZALEZ L L | 2008 | Fuel2008，87，7： | 1 |
| 7 | Cylindrocladium blight of Eucalyptus grandis in Colombia 显示文摘 | Rodas C A Lombard L Gryzenhout M | 2005 | Australasian Plant Pathology2005，34，2： | 1 |
| 8 | Characterization of morphospecies and strains of Microcystis (cyanobacteria) from natural populations and laboratory clones using cell probes (lectins and antibodies) 显示文摘 | Rodas V L Costas E | 1997 | J Phycol1997，33，： | 1 |
| 9 | Identification of marine dinoflagellates using fluorescent lectins 显示文摘 | Costas E Rodas V L | 1994 | J Phycol1994，30，： | 1 |
| 10 | High frequency railway vehicle-track dynamics through flexible rotating wheelsets显示文摘 | BAEZA L FAYOS J RODA A | 2008 | Vehicle System Dynamics2008，46，： | 1 |
| 11 | Railway Vehicle/Track Interaction Analysis Using a Modal Substructuring Approach显示文摘 | BAEZA L RODA A NIELSEN J C O | | 0，，293： | 1 |
| 12 | Calonectria (Cylindrodadium) species associated with dying Pinus cuttings 显示文摘 | Lombard L Rodas C A Crous P W | 2009 | Persoonia2009，23，： | 1 |
| 13 | Developmental and re- productive biology of Planococcus minor (Hemiptera: Pseudo- coccidae) under constant temperatures显示文摘 | Francis A W Kairo M T K Roda A L | 2012 | Florida Entomolo- gist2012，95，2： | 1 |
| 14 | Identification of marine dinoflagellates using fluorescent lectins 显示文摘 | Costas E Rodas V L | 1994 | J Phycol1994，30，： | 1 |
| 15 | The passionvine mealybug, Planococcusminor (Maskell) (Hemiptera:Pseudo- coecidae), and its natural enemies in the cocoa agroecosystem in Trinidad显示文摘 | Francis A W Kairo M T K Roda A L | 2012 | Biological Control2012，60，3： | 1 |
| 16 | Three new ca- ses of dysfibrinogenemia: Poissy Ⅲ, Saint - Germain I and Tahiti 显示文摘 | MATHONNET F PELTIER J Y RODA L | 2001 | Thromb Res2001，103，3： | 1 |
| 17 | Histologicfeatures of the CISH procedure显示文摘 | Mettler L | 1994 | Am J Assoc Gynecol Laparosc1994，2，： | 1 |
| 18 | Comparison of biota sample pretreatments for arsenic speciation with coupled HPLC-HG-ICP-MS 显示文摘 | Ariza J L G Rodas D S Giraldez I | 2000 | Analyst2000，，125： | 1 |
| 19 | Cylindrocladium blight of Eucalyptus grand/s in Colombia显示文摘 | Rodas C A Lombard L Gryzenhout M | 2005 | Australasian Plant Pathology2005，34，2： | 1 |
| 20 | Development and validation of a sensitive HPLC-ESI-MS/MS method for the direct determination of glucosamine in human plasma显示文摘 | Roda A Sabatini L Barbieri A | 2006 | J Chromatogr B:Analyt Technol Biomed Life Sci2006，844，1： | 1 |
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