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| 1 | Alzheimer’s disease and type 2 diabetes mellitus:Pathophysiologic and pharmacotherapeutics links显示文摘At present,Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two highly prevalent disorders worldwide,especially among elderly individuals.T2DM appears to be associated with cognitive dysfunction,with a higher risk of developing neurocognitive disorders,including AD.These diseases have been observed to share various pathophysiological mechanisms,including alterations in insulin signaling,defects in glucose transporters(GLUTs),and mitochondrial dysfunctions in the brain.Therefore,the aim of this review is to summarize the current knowledge regarding the molecular mechanisms implicated in the association of these pathologies as well as recent therapeutic alternatives.In this context,the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain,increase in reactive oxygen species,and production of mitochondrial alterations that occur in T2DM.These findings have contributed to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs,or,more recently,azeliragon,amylin,among others,which have shown possible beneficial effects in diabetic patients diagnosed with AD. | Milagros Rojas Mervin Chávez-Castillo Jordan Bautista Ángel Ortega Manuel Nava Juan Salazar Edgar Díaz-Camargo Oscar Medina Joselyn Rojas-Quintero Valmore Bermúdez | 2021 | World Journal of Diabetes2021，12，6： | 5 |
| 2 | Planum temporale volume in children and adolescents with autism显示文摘 | Rojas D C Camou S L Reite M L | 2005 | J Autism Dev Disord2005，35，： | 1 |
| 3 | Diagnosis and management of intramural ectopic pregnancy显示文摘 | Bannon K Fernandez C Rojas D et td | 2013 | I Minim Invasive Gynecol2013，20，5： | 1 |
| 4 | Vacuolar-type H + -ATPases at the plasma membrane regulate pH and cell migration in microvascular endothelial cells显示文摘 | Rojas J D Sennoune S R Maiti D | 2006 | Am J Physiol Heart Circ Physiol2006，291，3： | 1 |
| 5 | The Anx7(+/-) knockout mutation alters electrical and secretory responses to Ca2+-mobilizing agents in pancreatic β-cells显示文摘 | Mears D Zimliki C L Atwater I Rojas E Glassman M Leighton X | 2012 | Cell Physiol Biochem2012，29，： | 1 |
| 6 | United States' International Retirement Migratian:The Reasons for Retiring to the Environs of Lake Chapala, Mexico 显示文摘 | Sunil T S Rojas V Bradley D E | 2007 | Ageing and Society2007，27，4： | 1 |
| 7 | Plasma-electrolytes in Natives to Hypoxia after Marathon Races at Different Altitudes显示文摘 | SCHMIDT W ROJAS J BONING D | 1999 | Med Sci Sports Exe1999，31，： | 1 |
| 8 | Role of TLR2- and TLR4 -mediated signaling in Mycobacterium tuberculosis-induced maerophage death显示文摘 | Sanchez D Rojas M Hernandez I | | Cell Imnmnol0，19，10： | 1 |
| 9 | Nanosized LiMYMn2-YO4(M=Cr,Co and Ni) spinels synthesized by a sucrose-aided combustion method:Structural characterization and electrochemical properties显示文摘 | AMARILLA J M ROJAS R M PICO F PASCUAL L PETROV K KOVACHEVA D LAZARRAGA MG LEJONA I ROJO J M | 2007 | J Power Sources2007，17，2： | 1 |
| 10 | Wood species identification using stress-wave analysis in the audible range显示文摘 | ROJAS J A M ALPUENTE J POSTIGO D | 2011 | Applied Acoustics2011，72，12： | 1 |
| 11 | Breeding system and factors limiting fruit production in the nectarless orchid Broughtonia lindenii显示文摘 | Valel A Rojas D Alvarez J C | 2011 | Plantbiology2011，，： | 1 |
| 12 | Transcystic common bile duct exploration in the management of patients with choledocholithiasis显示文摘 | Rojas Ortega S Arizoe Bravo D Marin Lopez E R | 2003 | J Gastrointest Surg2003，7，4： | 1 |
| 13 | Studies on acetate ester production by non-Saccharomyces wine yeasts 显示文摘 | Virginia Rojas Jose V Gil Francisco Pinaga et (d | 2001 | International Journal of Food Microbiology2001，70，： | 1 |
| 14 | Identification of mammalian noggin and its expression in the adult nervous system显示文摘 | Economides A N Rojas E | 1995 | J Neurosci1995，15，9： | 1 |
| 15 | Role of TLR2- and TLR4-mediated signaling in Mycobacterium tuberculosis-induced macrophage death 显示文摘 | Samchez D Rojas M Hernandez I | 2010 | Cell Immunol2010，260，2： | 1 |
| 16 | Cadmium exposure and the epigenome:exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs显示文摘 | Sanders AP Smeester L Rojas D | 2014 | Epigenetics2014，9，2： | 1 |
| 17 | Development of diagnostic tools for the analysis of 5p deletions using interphase FISH显示文摘 | Gersh M Grady D Roja SK | 1997 | Cytogenet Cell Genet1997，77，34： | 1 |
| 18 | Artificial diet and rearing methods for Thanasimus dubius (Coleoptera: Cleridae), a predator of bark beetles ( Coleoptera: Scolytidae) 显示文摘 | Reeve J D Rojas G M Morales-Ramos J A | 2003 | Biological Control2003，27，： | 1 |
| 19 | Incretin-basedtherapy for type 2 diabetes mellitus: pancreatic and extrapan-creatic effects显示文摘 | Hartman I Rojas E Rodriguez_ Molina D | 2013 | Am J Ther2013，20，4： | 1 |
| 20 | Agrobacterium rhizogens mediated transformation of Rauvolfia serpentina:Regeneration and alkaloid synthesis显示文摘 | Benjamin B D Roja G Heble M R | 1993 | Plant Cell Tissue and Organ Culture1993，35，： | 1 |
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