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| 1 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 2 | A broadly applicable,personalized heat shock protein-mediated oncolytic tumorvaccine 显示文摘 | HUANG X F REN W ROLLINS L | 2003 | CancerRes2003，63，21： | 1 |
| 3 | Nanoscale cavities for nanoparticles in pertluofinated ionomer membranes 显示文摘 | Rollins H W Lin F Johnson J | 2000 | Langmuir2000，，16： | 1 |
| 4 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 5 | Large-scale structure of genomic methylation patterns 显示文摘 | Rollins RA Haghighi F Edwards JR | 2006 | Genome Res2006，16，2： | 1 |
| 6 | Management of mixed-species,uneven-aged forests in the french Jura:from stochastic growth and price models to decision tables显示文摘 | Rollin F Buongiorno J Zhou M Peyron J-L | | 0，，01： | 1 |
| 7 | Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentia- tion显示文摘 | HUBE F VELASCO G ROLLIN J | 2011 | Nucleic Acids Res2011，39，2： | 1 |
| 8 | Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL- l0, and tumor necrosis factor-alpha associated with fatal Ebola vi- rus infection显示文摘 | Villinger F Rollin PE Brar SS | 1999 | J Infect Dis1999，179，1： | 1 |
| 9 | Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation显示文摘 | Hube F Velasco G Rollin J | 2011 | Nucleic Acids Res2011，39，2： | 1 |
| 10 | Highly effective SNP-based association mapping and management of recessive defects in livestock显示文摘 | CHARLIER C COPPIETERS W ROLLIN F | 2008 | Nat Genet2008，40，4： | 1 |
| 11 | A common pesticide decreases foraging success and survival in honey bees显示文摘 | Henry M Beguin M Requier F Rollin O Odoux J F Aupinel P Aptel J Tchamitchian S Decourtye A | 2012 | Science2012，336，6079： | 1 |
| 12 | Differential proteome of bone marrow mesenchymal stem cells from osteoarthritis patients显示文摘 | Rollin R Marco F Camafeita E | | 0，，： | 1 |
| 13 | The somatic common deletion in mitochondrial DNA is decreased in schizophrenia显示文摘 | Mamdani F Rollins B Morgan L | 2014 | Schizophr Res2014，159，23： | 1 |
| 14 | Highly effec-tive SNP - based association mapping and management of recessivedefects in livestock显示文摘 | CHARLIER C COPPIETERS W ROLLIN F | 2008 | Nat Genet2008，40，4： | 1 |
| 15 | Early lymphocyte activation in the synovial tnicroenvironment in patients with osteoarthritis comparison with rheumatoid arthritis patients and healthy con- trois显示文摘 | Rollin R Marco F Jover JA | 2008 | Rheumatol Int2008，28，： | 1 |
| 16 | Markedly elevated levels of interferon ( IFN ) -gamma, IFN-alpha, interleukin (IL) -2, IL-10,and tumor necrosis factor-alpha associated with fatal Ebola virus infection显示文摘 | Villinger F Rollin P E Brar S S | 1999 | J Infect D/s1999，179，1： | 1 |
| 17 | Highly Effective SNP-Based Association Mapping and Management ofRecessive Defects in Livestock显示文摘 | Charlier C Coppieters W Rollin F | 2008 | Nat Genet2008，40，4： | 1 |
| 18 | Rapid Diagnosis of Ebola Hemorrhagic Fever by Reverse Transcription-PCR in an Outbreak Setting and Assessment of Patient Viral Load as a Predictor of Outcome显示文摘 | Towner J S Rollin P E Bausch D G Sanchez A Crary S M Vincent M Lee W F Spiropoulou C F Ksiazek T G Lukwiya M Kaducu F Downing R Nichol S T | 2004 | Journal of Virology2004，78，8： | 1 |
| 19 | Early lymphocyte ac- tivation in the synovial microenviromnent in patients with osteoar- thritis: comparison with rheumatoid arthritis patients and healthy controls 显示文摘 | ROLLIN R MARCO F JOVER J A | 2008 | Rheumatol Int2008，28，8： | 1 |
| 20 | Markedly elevated levels of interferon (IFN)-gamma, IFNalpha,interleukin (IL)-2, IL- l0, and tumor necrosis factor-alpha associated with fatal Ebola virus infeetion显示文摘 | Villinger F Rollin PE Brat SS | 1999 | J Infect Dis1999，179，1： | 1 |
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