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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Diabetes-and nondiabetes-Related Lower Extremity Amputation Incidence Before and After the Introduction of Better Organized Diabetes Foot Care:Continuous longitudinal monitoring using a standard method显示文摘 | Ronan J N igel C V illiam F | 2008 | Diabetes Care2008，31，5： | 1 |
| 3 | Mice lacking dipeptidyl peptidase Ⅳ are protected against obesity and insulin resistance显示文摘 | Conatello SL Li Z Ronan J | 2003 | Prac Natl Acad Sci USA2003，100，11： | 1 |
| 4 | Overexpression of cyclooxygenase-2 in non-small cell lung cancer显示文摘 | Petkova D K Clelland C Ronan J | 2004 | Respiratory Medicine2004，98，： | 1 |
| 5 | Diabetes-and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care : Continuous longitudinal monitoring using a standard method 显示文摘 | Ronan J Nigel C Villiam F | 2008 | Diabetes Care2008，31，3： | 1 |
| 6 | Overexpression of cyclooxygenase-2 in non-small cell lung cancer显示文摘 | Petkova D K Clelland C Ronan J | 2004 | Respir Med2004，98，2： | 1 |
| 7 | Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance 显示文摘 | CONARELLO S L LI Z H RONAN J | 2003 | Proc Natl Acad Sci USA2003，100，11： | 1 |
| 8 | Overexpression of cyclooxygenase-2 in non-small cell lung cancer显示文摘 | Petkova DK Clelland C Ronan J | 2004 | Respir Med2004，98，： | 1 |
| 9 | Further refinement of the MYP2 locus for autosomal dominant high myopia by linkage disequilibrium analysis显示文摘 | Young TL Atwood LD Ronan SM Dewan AT Alvear AB Peterson J | 2001 | Ophthalmic Genet2001，22，2： | 1 |
| 10 | Further refinement of the MYP2 locus for autosomal dominant high myopia by linkage disequilibrium analysis 显示文摘 | Young TL Atwood LD Ronan SM Dewan AT Alvear AB Peter- son J | 2001 | Ophthalmic Genet2001，22，2： | 1 |
| 11 | A spice ii subcircuit representation for power mosfets using empirical methods显示文摘 | Dolny G M Ronan J H R Wheatley J C F | | 0，，： | 1 |
| 12 | Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance 显示文摘 | Conarello SL Li Z Ronan J | 2003 | Proc Natl Acad Sci USA2003，100，11： | 1 |
| 13 | Overexpression of cyclooxygenase-2 in non-small cell lung cancer显示文摘 | Petkova DK Clelland C Ronan J | 2004 | Respir Med2004，98，： | 1 |
| 14 | An adapter ligation-mediated PCR method for high-throughput mapping of T-DNA inserts in the Arabidopsis genome显示文摘 | Ronan C O Jose M A Christopher J K | 2007 | Nature Protocols2007，2，11： | 1 |
| 15 | Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance显示文摘 | Conarello S L Li Z Ronan J | 2003 | Proc Natl Acad Sci U S A2003，100，11： | 1 |
| 16 | Sensation seeking among high- and lower-risk sport participants显示文摘 | Jack S J Ronan K R | 1998 | Journal of personality and Individual Difference1998，25，： | 1 |
| 17 | Effect of D, L-2-difluoromethylornithine and endocrine manipulation on the induction of mammary carcinogenesis by 1-methyl-1-nitrosourea 显示文摘 | Thompson H J Ronan AM | 1986 | Carcinogenesis1986，7，： | 1 |
| 18 | Building buildings 显示文摘 | Ronan M A Tits J | 1987 | Math Annalen1987，278，： | 1 |
| 19 | Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance显示文摘 | Conarello SL Li Z Ronan J | 2003 | Proc Natl Acad Sci USA2003，100，11： | 1 |
| 20 | Overexpressiou of cyclooxygenase-2 in non-small cell lung cancer 显示文摘 | Petkova DK Clelland C Ronan J | 2004 | Resir Med2004，98，2： | 1 |
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