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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Spreadsheet Analysis and Design显示文摘 | Ronen B Palley M A Lucas H C J R | 1989 | Communications of the ACM1989，32，1： | 1 |
| 3 | Critical Chain:A New Project Management Paradigm or Old Wine in New Bottles?显示文摘 | LECHLER T G RONEN B EDWARDA S | 2005 | Engineering Management Journal2005，17，4： | 1 |
| 4 | Oxalate balance in fat sand rats feeding on high and low calcium diets显示文摘 | Palgi N Ronen Z Pinshow B | 2008 | J Comp Phys B2008，178，5： | 1 |
| 5 | Impact of three-dimensional parametric modeling of buildings on productivity in structural engineering practice 显示文摘 | Rafael S Ronen B | 2008 | Automation in Construction2008，，4： | 1 |
| 6 | Spreadsheet Analysis and Design显示文摘 | Ronen B Palley M A Lucas H C J R | 1989 | Communications of the ACM1989，32，1： | 1 |
| 7 | Escherichia coli mazEF- mediated cell death is triggered by various stressful conditions 显示文摘 | RONEN H SAT B ENGELBERG-KULKA H | 2004 | J Bacteriol2004，6，1： | 1 |
| 8 | Drum-Buffer-Rope Shop Floor Control显示文摘 | Schragenheim E Ronen B | 1990 | Production and Inventory Management Journal1990，31，3： | 1 |
| 9 | Synchronized manufacturing as in OPT:from practice to theory显示文摘 | RONEN B STAIR M K | 1990 | Computers Industrial Engineering1990，18，4： | 1 |
| 10 | A double moral hazard model of organization design显示文摘 | Elazar B Ronen I Yossi S | 2010 | Journal of Economics & Management Strategy2010，1，： | 1 |
| 11 | Production outsourcing: a linear programming model for the theory-of-constraints 显示文摘 | COMAN A RONEN B | 2000 | International Journal of Production Research2000，38，7： | 1 |
| 12 | Peak management 显示文摘 | RONEN B COMAN A SCHRAGENHEIM E | 2001 | Int J Prod Res2001，39，14： | 1 |
| 13 | Drum - Buffer- Rope Shop Floor Control显示文摘 | Schragenhein E Ronen B | 1990 | Production and Inventory Management Journal1990，3，： | 1 |
| 14 | Buffer Management: a Diagnostic Tool for Production Control显示文摘 | Schragenhein E Ronen B | 1991 | Production and Inventory Management Journal1991，，2： | 1 |
| 15 | Synchronized Manufacturing as in OPT: from Practice to Theory显示文摘 | Ronen B Starr M K | 1990 | Computer Industrial Engineering1990，18，4： | 1 |
| 16 | Managing system constraints:a cost/utilization approach显示文摘 | SPECTOR Y | 1992 | International Journal of Production Research1992，30，9： | 1 |
| 17 | Assigning numbersto the arrows : parameterizing a gene regulation network by usingaccurate expression kinetics显示文摘 | Ronen M Rosenberg R Shraiman B I | 2002 | Proceedings of the national acade-my of sciences2002，99，10： | 1 |
| 18 | Drum-buffer-rope shop floor control 显示文摘 | Ronen B | 1990 | Production and Inventory Management Journal1990，31，3： | 1 |
| 19 | Conformant planning via heuristic forward search:A new approach显示文摘 | Jorg H Ronen I B | 2006 | Artificial Intelligence2006，170，67： | 1 |
| 20 | Improving Shop Floor Control; an Entropy Model Approach显示文摘 | Karp A Ronen B | 1992 | International Jour nal of Production Research1992，30，4： | 1 |
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