| 2 | Mast cell stabilizing and antiallergic activity of Abrus precatorius in the management of asthma显示文摘Objective:To investigate effects of ethanol extract of Abrus precatorius leaves(EAPL) on egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats. Methods:In present study ethanol extract of Abrus precatorius leaves(EAPL) at doses of 100,125, 150 mg/kg i.p were evaluated for preliminary phytochemical screening,acute toxicity studies and egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats. Results:The results of present investigation showed that the LD50 of EAPL is more than 1300 mg/ kg.EAPL(100-150 mg/kg,i.p.) significantly protect egg albumin induced degranulation of mast cell and inhibit area of leakage of dye in passive cutaneous anaphylaxis.Phytochemical studies observed presence of saponin,alkaloids,flavonoids,and glycosides.Conclusions:In conclusion EAPL possesses anti asthmatic potential. | DJ Taur RY Patil | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，1： | 1 |
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