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| 1 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 2 | Integration of community health workers into health systems in developing countries:Opportunities and challenges显示文摘Background:Developing countries have the potential to reach vulnerable and underserved populations marginalized by the country’s health care systems by way of community health work-ers(CHWs).It is imperative that health care systems focus on improving access to quality continu-ous primary care through the use of CHWs while paying attention to the factors that impact on CHWs and their effectiveness.Objective:To explore the possible opportunities and challenges of integrating CHWs into the health care systems of developing countries.Methods:Six databases were examined for quantitative,qualitative,and mixed-methods stud-ies that included the integration of CHWs,their motivation and supervision,and CHW policy making and implementation in developing countries.Thirty-three studies met the inclusion criteria and were double read to extract data relevant to the context of CHW programs.Thematic coding was conducted and evidence on the main categories of contextual factors influencing integration of CHWs into the health system was synthesized.Results:CHWs are an effective and appropriate element of a health care team and can assist in addressing health disparities and social determinants of health.Important facilitators of integration of CHWs into health care teams are support from other health workers and inclusion of CHWs in case management meetings.Sustainable integration of CHWs into the health care system requires the formulation and implementation of polices that support their work,as well as financial and nonfinancial incentives,motivation,collaborative and supportive supervision,and a manageable workload.Conclusions:For sustainable integration of CHWs into health care systems,high-performing health systems with sound governance,adequate financing,well-organized service delivery,and adequate supplies and equipment are essential.Similarly,competent communities could contrib-ute to better CHW performance through sound governance of community resources,promotion of inclusiveness and cohesion,engagement in participatory decision making,and mobilization of local resources for community welfare. | Collins Otieno Asweto Mohamed Ali Alzain Sebastian Andrea Rachel Alexander Wei Wang | 2016 | Family Medicine and Community Health2016，4，1： | 2 |
| 3 | Sodium nitrate particles: physical and chemical properties during hydration and dehydration, and implications for aged sea salt aerosols显示文摘 | Rachel H Alexander L Barbara F | 2004 | Aerosol Science2004，，： | 1 |
| 4 | Metabolomics as a diagnostic tool for hepatology: validation in a naturally occurring canine model显示文摘 | Phillip David Whitfield Peter-John Mantyla Noble Hilary Major Robert Jeffrey Beynon Rachel Burrow Alistair Iain Freeman Alexander James German | 2005 | Metabolomics2005，，3： | 1 |
| 5 | Comparative effectiveness of minimally invasive versus traditional sternotomy mitral valve surgery in elderly patients显示文摘 | Alexander Iribarne Rachel Easterwood Mark J. Russo Edward Y. Chan Craig R. Smith Michael Argenziano | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，4： | 1 |
| 6 | Comparative biomechanic performances of locked C four Strand flexor tendon repairs in an ex vivo porcine model 显示文摘 | Alexander Croog Rachel Goldstein Philip Nasser | 2007 | J Hand Surg (Am)2007，32，2： | 1 |
| 7 | Comparative biomechanic performances of locked C four Strand flexor tendon repairs in an ex vivo porcine model显示文摘 | Alexander Croog Rachel Goldstein Philip Nasser | 2007 | J Hand Surg(Am)2007，32，2： | 1 |
| 8 | Modelling tidal current turbine wakes using a coupled RANS-BEMT approach as a tool for analysing power capture of arrays of turbines显示文摘 | Stephen R. Turnock Alexander B. Phillips Joe Banks Rachel Nicholls-Lee | 2011 | Ocean Engineering2011，，11： | 1 |
| 9 | Prevalence and clinical outcomes of the 46/1 haplotype, Janus kinase 2 mutations, and ten‐eleven translocation 2 mutations in budd‐chiari syndrome and their impact on thrombotic complications post Liver Transplantation显示文摘 | Rachel H. Westbrook Nicholas C. Lea Azim M. Mohamedali Alexander E. Smith David W. Orr Lara N. Roberts Nigel D. Heaton Julia A. Wendon John G. O’Grady Michael A. Heneghan Ghulam J. Mufti | 2012 | Liver Transpl2012，，7： | 1 |
| 10 | Dietary mineral supplies in Africa显示文摘 | Edward J. M. Joy E. Louise Ander Scott D. Young Colin R. Black Michael J. Watts Allan D. C. Chilimba Benson Chilima Edwin W. P. Siyame Alexander A. Kalimbira Rachel Hurst Susan J. Fairweather‐Tait Alexander J. Stein Rosalind S. Gibson Philip J. White Mart | 2014 | Physiol Plantarum2014，，3： | 1 |
| 11 | Heterogeneity of fibrosis patterns in non‐alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways显示文摘 | Richard Skoien Michelle M. Richardson Julie R. Jonsson Elizabeth E. Powell Elizabeth M. Brunt Brent A. Neuschwander‐Tetri Prithi S. Bhathal John B. Dixon Paul E. O’Brien Herbert Tilg Alexander R. Moschen Ulrich Baumann Rachel M. Brown Richard T. Couper Ni | 2013 | Liver Int2013，，4： | 1 |
| 12 | Current concepts in mild cognitive impairment显示文摘 | Ronald C Rachelle D Alexander K et al | 2001 | Arch Neurol2001，58，10： | 1 |
| 13 | Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial显示文摘 | Badara Cissé Cheikh Sokhna Denis Boulanger Jacqueline Milet El Hadj Ba Keshena Richardson Rachel Hallett Colin Sutherland Kirsten Simondon Fran?ois Simondon Neal Alexander Oumar Gaye Geoffrey Targett Jo Lines Brian Greenwood Jean-Fran?ois Trape | 2006 | The Lancet2006，，9511： | 1 |
| 14 | Outcomes and Predictors of Early Mortality After Continuous-Flow Left Ventricular Assist Device Implantation as a Bridge to Transplantation显示文摘 | Anton Sabashnikov Prashant N. Mohite Bartlomiej Zych Diana García Aron-Frederik Popov Alexander Weymann Nikhil P. Patil Rachel Hards Massimo Capoccia Thorsten Wahlers Fabio De Robertis Toufan Bahrami Mohamed Amrani Nicholas R. Banner André R. Simon | 2014 | ASAIO Journal2014，，2： | 1 |
| 15 | The golden age of minimally invasive cardiothoracic surgery: current and future perspectives显示文摘 | Alexander Iribarne Rachel Easterwood Edward YH Chan Jonathan Yang Lori Soni Mark J Russo Craig R Smith Michael Argenziano | 2011 | Future Cardiol2011，，3： | 1 |
| 16 | Fat‐Soluble Vitamins in Advanced CKD/ESKD: A Review显示文摘 | Rachel M.Holden VincentKi Alexander RossMorton CatherineClase | 2012 | Seminars in Dialysis2012，，3： | 1 |
| 17 | Methods for extracellular vesicle isolation from cancer cells显示文摘Cells are known to release different types of vesicles such as small extracellular vesicles(sEVs)and large extracellular vesicles(LEVs).sEVs and LEVs play important roles in intercellular communication,pre-metastatic niche formation,and disease progression;both can be detected cell culture media and biological fluids.sEVs and LEVs contain a variety of protein and RNA cargo,and they are believed to impact many biological functions of the recipient cells upon their internalization or binding to cell surface proteins.It has recently been established that standard isolation techniques,such as differential ultracentrifugation,yield a mixed population of EVs.However,density gradient ultracentrifugation has been reported to allow the isolation of sEVs without cellular debris.Here,we describe the most common methods used to isolate sEVs from cell culture medium,mouse and human plasma,and a new technique for isolating sEVs from tissues as well.This article also provides detailed procedures to isolate LEVs. | Israa Salem Nicole M.Naranjo Amrita Singh Rachel DeRita Shiv Ram Krishn Luca S.Sirman Fabio Quaglia Alexander Duffy Nicholas Bowler Aejaz Sayeed Lucia R.Languino | 2020 | Cancer Drug Resistance2020，3，3： | 0 |
| 18 | 小鼠生命早期砷暴露与A型流感病毒感染的急性和长期反应显示文摘[背景]砷是一个重要的全球环境健康问题。已有研究显示,生命早期砷暴露会导致婴儿期呼吸道感染发生率增加、儿童期肺功能下降、成年早期支气管扩张发生率增加。[目的]确定小鼠在生命早期的砷暴露是否会加剧其生命早期流感病毒感染的反应性。[方法]在宫内与整个产后生活中均使C57BL/6小鼠处于砷暴露状态。在1周龄时,令小鼠的一个亚组感染A型流感,然后评估砷暴露对病毒的清除、炎症、肺部结构和肺功能的急性和长期影响。[结果]生命早期的砷暴露使得小鼠对A型流感病毒的清除率下降、炎症反应加剧,并导致呼吸力学和气道结构的急性和长期性改变。[结论]在整个生命早期,砷暴露群体呼吸道感染的易感性增加合并炎症反应加剧可能会导致支气管扩张。 | Kathryn A. Ramsey Rachel E. Foong Peter D. Sly Alexander N. Larcombe Graeme R. Zosky | 2014 | 环境与职业医学2014，31，2： | 0 |
| 19 | Hepatic pseudotumor associated with Strongyloides infection:A case report显示文摘BACKGROUND Strongyloides sterocoralis is a parasitic infection caused by a roundworm that is transmitted through soil contaminated with larvae.It can infrequently cause hepatic abscesses in immunocompromised patients and is rarely reported to form hepatic lesions in immunocompetent hosts.CASE SUMMARY We present a case study of a 45-year-old female who presented with right upper quadrant abdominal pain and constitutional symptoms for several weeks.Crosssectional imaging identified several malignant-appearing liver masses.Further investigation,including serological testing and histopathologic examination,revealed the presence of serum Strongyloides antibodies and hepatic granulomas with extensive necrosis.Following treatment with ivermectin for 2 wk,there was complete resolution of the liver lesions and associated symptoms.CONCLUSION This case highlights the importance of considering parasitic infections,such as Strongyloides,in the differential diagnosis of hepatic masses.Early recognition and appropriate treatment can lead to a favorable outcome and prevent unnecessary invasive procedures.Increased awareness among clinicians is crucial to ensure the timely diagnosis and management of such cases. | Jessica P Gialanella Tyler Steidl Kokkola Korpela Miral S Grandhi Russell C Langan H Richard Alexander Rachel M Hudacko Brett L Ecker | 2023 | World Journal of Hepatology2023，15，12： | 0 |
| 20 | Potential impacts of UV exposure on lichen communities:a pilot study of Nothofagus dombeyi trunks in southernmost Chile显示文摘High-latitude terrestrial ecosystems face the triple threats of climate warming,increased exposure to UV arising from polar ozone depletion,and deforestation.Lichen communities of southernmost Chile are recognized for their high diversity,which includes nitrogen-fixing cyanolichens.Such lichens are common on forest trees,contribute nitrogen to forests,and are sensitive to exposure following deforestation(widespread in this region).In a pilot study of exposure effects on tree lichens,using nondestructive imaging methods,we compared lichen communities on trunks of isolated vs.forest tree trunks of southern Chilean beech(Nothofagus dombeyi,Nothofagaceae).We chose trees of similar diameter and trunk lean angle in conserved forest and nearby logged meadow on Navarino Island,XII Region Magallanes and Chilean Antarctica,Chile,within the annual southern ozone hole.Ninety-five percent of cyanolichen records,including Nephroma antarcticum,and 66%of records for other foliose lichens were from the forest,whereas pendulous usneoid lichens dominated N.dombeyi bark at the meadow site.Limitation of cyanolichen growth on isolated trees could affect ecosystem function in this poorly studied habitat.Possible factors contributing to strong community differences were increased light intensity,UV radiation,and wind stress,plus limited ability of lichens to colonize isolated trees in the logged meadow.UV radiation was likely an important stressor for some lichen species but not others.We recommend more extensive monitoring to pinpoint causes of differing lichen communities,and we encourage better protection of bark-dwelling lichens in southern hemisphere regions facing multiple threats. | Marie T.Trest Susan Will-Wolf Rachel Keuler Nathaniel Shay Karen Hill Alyssa Studer Andy Muench Zachary Alexander Axel Adams Leah Dittberner Martin Feehan Hannah Lee Nicholas Galleguillos-Katz Joy B.Zedler Linda Graham Patricia Arancibia-Avila | 2015 | Ecosystem Health and Sustainability2015，1，4： | 0 |
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