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| 1 | Halide Homogenization for High-Performance Blue Perovskite Electroluminescence显示文摘Metal halide perovskite light-emitting diodes(LEDs)have achieved great progress in recent years.However,bright and spectrally stable blue perovskite LED remains a significant challenge.Three-dimensional mixed-halide perovskites have potential to achieve high brightness electroluminescence,but their emission spectra are unstable as a result of halide phase separation.Here,we reveal that there is already heterogeneous distribution of halides in the as-deposited perovskite films,which can trace back to the nonuniform mixture of halides in the precursors.By simply introducing cationic surfactants to improve the homogeneity of the halides in the precursor solution,we can overcome the phase segregation issue and obtain spectrally stable single-phase blueemitting perovskites.We demonstrate efficient blue perovskite LEDs with high brightness,e.g.,luminous efficacy of 4.7,2.9,and 0.4 lmW^(-1) and luminance of over 37,000,9,300,and 1,300 cdm^(-2) for sky blue,blue,and deep blue with Commission Internationale de l’Eclairage(CIE)coordinates of(0.068,0.268),(0.091,0.165),and(0.129,0.061),respectively,suggesting real promise of perovskites for LED applications. | Lu Cheng Chang Yi Yunfang Tong Lin Zhu Gunnar Kusch Xiaoyu Wang Xinjiang Wang Tao Jiang Hao Zhang Ju Zhang Chen Xue Hong Chen Wenjie Xu Dawei Liu Rachel AOliver Richard HFriend Lijun Zhang Nana Wang Wei Huang Jianpu Wang | 2020 | Research2020，，1： | 4 |
| 2 | Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense显示文摘 | Yves S.-Y. Hsieh Cheng Chien Sylvian K.-S. Liao Shih-Fen Liao Wei-Ting Hung Wen-Bin Yang Chih-Chien Lin Ting-Jen Rachel Cheng Chia-Chuan Chang Jim-Min Fang Chi-Huey Wong | 2008 | Bioorganic & Medicinal Chemistry2008，，11： | 2 |
| 3 | LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease显示文摘Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD. | Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 4 | GLUTAMINE REDUCES CYTOKINE RELEASE, ORGAN DAMAGE, AND MORTALITY IN A RAT MODEL OF ENDOTOXEMIA显示文摘 | Paul E. Wischmeyer Madelyn Kahana Rachel Wolfson Hongyu Ren Mark M. Musch Eugene B. Chang | 2001 | Shock2001，，5： | 1 |
| 5 | The extended QUALIFLEX method for multiple criteria decision analysis based on interval type-2 fuzzy sets and applications to medical decision making显示文摘 | Chen T Y Chang C H Rachel Lu J F | 2013 | European J of Operational Research2013，226，3： | 1 |
| 6 | Beyond frequency: who is most bothered by vasomotor symptoms?显示文摘 | Rebecca C. Thurston Joyce T. Bromberger Hadine Joffe Nancy E. Avis Rachel Hess Carolyn J. Crandall Yuefang Chang Robin Green Karen A. Matthews | 2008 | Menopause2008，，： | 1 |
| 7 | Lung epithelial branching program antagonizes alveolar differentiation显示文摘 | Daniel R. Chang Denise Martinez Alanis Rachel K. Miller Hong Ji Haruhiko Akiyama Pierre D. McCrea Jichao Chen | 2013 | Proceedings of the National Academy of Sciences2013，，45： | 1 |
| 8 | Robust genome and RNA editing via CRISPR nucleases in PiggyBac systems显示文摘CRISPR/Cas-mediated genome editing in human pluripotent stem cells(hPSCs)offers unprecedented opportunities for developing in vitro disease modeling,drug screening and cell-based therapies.To efficiently deliver the CRISPR components,here we developed two all-in-one vectors containing Cas9/gRNA and inducible Cas13d/gRNA cassettes for robust genome editing and RNA interference respectively.These vectors utilized the PiggyBac transposon system,which allows stable expression of CRISPR components in hPSCs.The Cas9 vector PB-CRISPR exhibited high efficiency(up to 99%)of inducing gene knockout in both protein-coding genes and long non-coding RNAs.The other inducible Cas13d vector achieved extremely high efficiency in RNA knockdown(98%knockdown for CD90)with optimized gRNA designs.Taken together,our PiggyBac CRISPR vectors can serve as powerful toolkits for studying gene functions in hPSCs. | Yuqian Jiang Rachel Catherine Hoenisch Yun Chang Xiaoping Bao Craig E.Cameron Xiaojun Lance Lian | 2022 | Bioactive Materials2022，7，8： | 0 |
| 9 | 中国新零售显示文摘面对渴望新奇和能快速适应新技术的消费者,中国的零售商比西方同行更有可能去冒险,推出一些可能仍处在测试阶段、在更注重隐私保护的市场可能会遭到抵制的模式和功能。在阿里巴巴集团和腾讯控股有限公司等科技巨头的带领下,中国企业正在测试一系列新概念,如人脸识别支付系统和全自动便利商店。它们吸引了全世界的目光。 | Rachel Chang Chris Philpot(插图) | 2018 | 商业周刊(中文版)2018，0，22： | 0 |
| 10 | 抛弃六西格玛管理学海尔重振家电业务显示文摘2016年,中国海尔集团完成了以54亿美元收购通用电气家电(General Electric Appliances,下文简称“GE家电”)的交易,几周后,海尔集团董事局主席张瑞敏站在GE家电500名焦虑的白领工人面前,后者向他抛出了一连串事关自己未来命运的问题。张瑞敏并非领会不到这其中的讽刺意味,这位在中国作为巨型集团企业先锋而备受尊重的企业家,对外面的世界而言却几乎只是一个无名之辈。 | Rachel Chang 布雨(译) | 2019 | 商业周刊(中文版)2019，0，4： | 0 |
| 11 | 中国消费者也不想到实体店买生鲜了显示文摘亚马逊(Amazon)以137亿美元收购全食超市(Whole Foods Markets)的交易让美国超市行业不寒而栗,超市运营商们担心亚马逊会先于他们解决美国电商行业的一大难题:让生鲜食品也能像书籍、电脑这类商品一样快速可靠地送达网购消费者。但要了解网络超市购物的耒来发展,超市运营商还应该把注意力锁定世界最大的实体零售商沃尔玛(Wal—Mart Stores)。 | Rachel Chang 陶梦萦 | 2017 | 商业周刊(中文版)2017，0，24： | 0 |
| 12 | 产业政策利好广州升级“中国制造”显示文摘在11月初一个阳光明媚的下午,几十名软件工程师和设计师正在紧张地忙碌,准备“亿航184”的一次试飞。亿航184是一个紧凑的金属和玻璃吊舱,装有八副螺旋桨。无人机制造商广州亿航的创始人、董事长兼首席执行官胡华智表示, | Dexter Roberts Tom Mackenzie Haze Fan Rachel Chang 永年 | 2017 | 商业周刊(中文版)2017，0，24： | 0 |
| 13 | Multiple reaction monitoring for the detection of disease-related synaptic proteins显示文摘Synaptic dysfunction occurs early in Alzheimer’s disease(AD)and is acknowledged as a primary pathologic target for treatment.Synaptic degeneration is the pathological feature most strongly correlated with loss of cognitive function ante mortem(Terry et al.,1991).Synapses are heavily damaged in hippocampal and neocortical regions of AD brain,whereas motor and occipital cortices are relatively spared(Honer et al.,1992).Despite extensive work,the molecular mechanisms underlying synaptic degeneration are largely unknown. | Rachel Yoon Kyung Chang Peter R.Dodd | 2014 | Neural Regeneration Research2014，9，23： | 0 |
| 14 | Advanced bioactive glue tethering Lubricin/PRG4 to promote integrated healing of avascular meniscus tears显示文摘Meniscus injuries are extremely common with approximately one million patients undergoing surgical treatment annually in the U.S. alone, but no regenerative therapy exist. Previously, we showed that controlled applications of connective tissue growth factor (CTGF) and transforming growth factor beta 3 (TGFβ3) via fibrin-based bio-glue facilitate meniscus healing by inducing recruitment and stepwise differentiation of synovial mesenchymal stem/progenitor cells. Here, we first explored the potential of genipin, a natural crosslinker, to enhance fibrin-based glue’s mechanical and degradation properties. In parallel, we identified the harmful effects of lubricin on meniscus healing and investigated the mechanism of lubricin deposition on the injured meniscus surface. We found that the pre-deposition of hyaluronic acid (HA) on the torn meniscus surface mediates lubricin deposition. Then we implemented chemical modifications with heparin conjugation and CD44 on our bioactive glue to achieve strong initial bonding and integration of lubricin pre-coated meniscal tissues. Our data suggested that heparin conjugation significantly enhances lubricin-coated meniscal tissues. Similarly, CD44, exhibiting a strong binding affinity to lubricin and hyaluronic acid (HA), further improved the integrated healing of HA/lubricin pre-coated meniscus injuries. These findings may represent an important foundation for developing a translational bio-active glue guiding the regenerative healing of meniscus injuries. | Solaiman Tarafder Jaskirti Ghataure David Langford Rachel Brooke Ryunhyung Kim Samantha Lewis Eyen Julian Bensadoun Jeffrey T.Felix James L.Cook Chang H.Lee | 2023 | Bioactive Materials2023，，10： | 0 |
| 15 | 制药公司寻求扩大在华销售渠道显示文摘在江苏无锡一家医院的二楼,孩子们正坐在一个个淡绿色格档里看动画片。他们嘴上戴着雾化器,这是一种通过可吸入喷雾给予药物的装置。离他们不远的地方,家长们在埋头看手机,不时过来检查一下他们的孩子是不是在通过这种设备顺利吸入药物。 | Dong Lyu Rachel Chang Drew Armstrong John Lauerman、James Paton 许诺(译) | 2019 | 商业周刊(中文版)2019，0，23： | 0 |
| 16 | 机遇之地?显示文摘乐观者看到一幕转向大戏;悲观者称之为外国投资的坟墓
有没有哪个心智正常的企业高管愿意将大笔资金投入到一个中央计划的经济欠发达国家,一个以食品短缺、制造业落后和基础设施严重不足而闻名的地方? | Andy Sharp Sohee Kim Daniele Lepido Chris Anstey Serene Cheong Ben Bartenstein Rachel Chang Tomoko Yamazaki 永年(译) | 2018 | 商业周刊(中文版)2018，0，12： | 0 |
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