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| 1 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 2 | A prospective trial of volumetric intensity-modulated arc therapy vs conventional intensity modulated radiation therapy in advanced head and neck cancer显示文摘AIM: To prospectively compare volumetric intensitymodulated arc therapy(VMAT) and conventional intensity-modulated radiation therapy(IMRT) in coverage of planning target volumes and avoidance of multiple organs at risk(OARs) in patients undergoing definitive chemoradiotherapy for advanced(stage Ⅲ or Ⅳ)squamous cell cancer of the head and neck. METHODS: Computed tomography scans of 20 patients with advanced tumors of the larynx, naso-, oroand hypopharynx were prospectively planned using IMRT(7 field) and VMAT using two arcs. Calculated doses to planning target volume(PTV) and OAR were compared between IMRT and VMAT plans. Dose-volume histograms(DVH) were utilized to obtain calculated doses to PTV and OAR, including parotids, cochlea,spinal cord, brainstem, anterior tongue, pituitary and brachial plexus. DVH's for all structures were compared between IMRT and VMAT plans. In addition the planswere compared for dose conformity and homogeneity. The final treatment plan was chosen by the treating radiation oncologist. RESULTS: VMAT was chosen as the ultimate plan in 18 of 20 patients(90%) because the plans were thought to be otherwise clinically equivalent. The IMRT plan was chosen in 2 of 20 patients because the VMAT plan produced concentric irradiation of the cord which was not overcome even with an avoidance structure. For all patients, VMAT plans had a lower number of average monitor units on average(MU = 542.85) than IMRT plans(MU = 1612.58)(P < 0.001). Using the conformity index(CI), defined as the 95% isodose volume divided by the PTV, the IMRT plan was more conformal with a lower conformity index(CI = 1.61) than the VMAT plan(CI = 2.00)(P = 0.003). Dose homogeneity, as measured by average standard deviation of dose distribution over the PTV, was not different with VMAT(1.45 Gy) or IMRT(1.73 Gy)(P = 0.069). There were no differences in sparing organs at risk.CONCLUSION: In this prospective study, VMAT plans were chosen over IMRT 90% of the time. Compared to IMRT, VMAT plans used only one third of the MUs, had shorter treatment times, and similar sparing of OAR. Overall, VMAT provided similar dose homogeneity but less conformity in PTV irradiation compared to IMRT. This difference in conformity was not clinically significant. | Simon D Fung-Kee-Fung Rachel Hackett Lee Hales Graham Warren Anurag K Singh | 2012 | World Journal of Clinical Oncology2012，3，4： | 2 |
| 3 | p53 protein overexpression in low grade dysplasia (LGD) in barrett’s esophagus: Immunohistochemical marker predictive of progression显示文摘 | Allan P Weston Sushanta K Banerjee Prateek Sharma Trang M Tran Robert Richards Rachel Cherian | 2001 | The American Journal of Gastroenterology2001，，5： | 2 |
| 4 | Patterning self-assembledmonolayers显示文摘 | Rachel K Smith Penelope ALewis Paul S Weiss | 2004 | Progress in surface science2004，，75： | 1 |
| 5 | Coastal water source of short- lived halocarbons in New England 显示文摘 | Zhou Y Ruth K V Rachel S R | 2005 | Journal of Geophysical Research2005，，： | 1 |
| 6 | The effect of oxygen on the sporulation and toxicity of Bacillus sphericus 2362 显示文摘 | Mohamed I A K Rachel J L Keith J O | 1993 | Biotechnology letters1993，15，1： | 1 |
| 7 | δPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo显示文摘 | Rachel B Gary K S Daria M R | 2007 | Brain Res2007，1144，1： | 1 |
| 8 | Immobilization of TiO2 on pumice stone for the photocatalytic degradation of dyes and dye industry pollutants 显示文摘 | K Venkata Subba Rao A Rachel M Subrahmanyam | 2003 | Applied Catalysis B: Environmental2003，46，： | 1 |
| 9 | Biomarkers of systemic in- flammation and depression and fatigue in moderate clinically stable COPD显示文摘 | Khaled A Umme K Rachel D | 2011 | Respir Res2011，12，1： | 1 |
| 10 | Screening for depression in people with cancer: the accuracy of the hospital anxiety and depres- sion scale显示文摘 | Rachel M Kate K Stephen B | 2005 | Clin Effe in Nursing2005，9，3： | 1 |
| 11 | Immobilization of TiO2 on pumice stone for the photocatalytic degradation of dyes and dye industry pollu tants显示文摘 | Rao K V S Rachel A Subrahmanyam M | 2003 | Applied Catalysis B: Environmental2003，46，1： | 1 |
| 12 | Genetic targeting of astrocytes to combat neurodegenerative disease显示文摘Astrocytes, glial cells that interact extensively with neurons and other support cells throughout the central nervous system, have recently come under the spotlight for their potential contribution to, or potential regenerative role in a host of neurodegenerative disorders. It is becoming increasingly clear that astrocytes, in concert with microglial cells, activate intrinsic immunological pathways in the setting of neurodegenerative injury, although the direct and indirect consequences of such activation are still largely unknown. We review the current literature on the astrocyte’s role in several neurodegenerative diseases, as well as highlighting recent advances in genetic manipulation of astrocytes that may prove critical to modulating their response to neurological injury, potentially combatting neurodegenerative damage. | Rachel Kéry Allen P. F. Chen Gregory W. Kirschen | 2020 | Neural Regeneration Research2020，15，2： | 1 |
| 13 | Interlayer structure and molecular environment of alkylammonium layered silicates显示文摘 | Richard A Vaia Rachel K Teukolsky Emmanuel P Giannelis | 1994 | Chem Mater1994，6，7： | 1 |
| 14 | Inuence of purchaser perceptions and intentions on price for forest land parcels: A hedonic pricing approach显示文摘 | STEPHANIE S MICHAEL K RACHEL H | 2008 | Journal of Forest Eco- nomics2008，14，： | 1 |
| 15 | The evidence for 'flipping out' :a systematic review of the flipped classroom in nursing education 显示文摘 | Vasiliki B Heather B Rachel K | 2016 | Nurse Education Today2016，38，3： | 1 |
| 16 | Patterning self-assembled monolayers显示文摘 | Smith Rachel K Lewis Penelope A Weiss Paul S | 2004 | Prog Surf Sci2004，75，： | 1 |
| 17 | Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin 显示文摘 | Joseph L Rachel K Leo | 1999 | Medical Science1999，96，12： | 1 |
| 18 | The fibrin-specific streptokinase SKΔ59 is a potent fibrinolytic agent in vivo显示文摘 | Irina Y Rachel A Aiilyan K | 2006 | American Heart Association2006，114，： | 1 |
| 19 | Exposure of the US population to lead in 1991~1994显示文摘 | James L P Rachel B K Debra J B | 1998 | Environ Health Perspect1998，106，： | 1 |
| 20 | Morphology of the Corpus Callosum in Human Fetuses显示文摘 | Rachel K Thomas K Jeyaseelan L | 1997 | Clin Anat1997，10，： | 1 |
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