|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 2 | Enteric gram-negative bacilli bloodstream infections: 17 years’ experience in a neonatal intensive care unit显示文摘 | Leandro Cordero Rachel Rau David Taylor Leona W Ayers | 2004 | AJIC: American Journal of Infection Control2004，，4： | 1 |
| 3 | Space- Time Coded Systems using Continuous Phase Modulation 显示文摘 | Rachel L Maw Desmond Taylor P | 2007 | IEEE Transactions on Communication2007，55，11： | 1 |
| 4 | En- teric gram-negative bacilli bloodstream infection: 17 years'experi- ence in a neonatal intensive care unit 显示文摘 | Leandro Corder MD Rachel Rau MD David Taylor PhD | 2004 | In Con Epi2004，32，4： | 1 |
| 5 | Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin显示文摘 | Ergül Eyol Annemarie Boleij Rachel R. Taylor Andrew L. Lewis Martin R. Berger | 2008 | Clinical & Experimental Metastasis2008，，3： | 1 |
| 6 | Irinotecan drug eluting beads for use in chemoembolization: In vitro and in vivo evaluation of drug release properties显示文摘 | Rachel R. Taylor Yiqing Tang M. Victoria Gonzalez Peter W. Stratford Andrew L. Lewis | 2006 | European Journal of Pharmaceutical Sciences2006，，1： | 1 |
| 7 | A pre-clinical evaluation of silver, iodine and Manuka honey based dressings in a model of traumatic extremity wounds contaminated with Staphylococcus aureus显示文摘 | Hugo C. Guthrie Kevin R. Martin Christopher Taylor Abigail M. Spear Rachel Whiting Sara Macildowie Jonathan C. Clasper Sarah A. Watts | 2014 | Injury2014，，： | 1 |
| 8 | Method for hull-less barley transformation and manipulation of grain mixed-linkage beta-glucan显示文摘Hull-less barley is increasingly offering scope for breeding grains with improved characteristics for human nutrition; however, recalcitrance of hull-less cultivars to transformation has limited the use of these varieties. To overcome this limitation, we sought to develop an effective transformation system for hull-less barley using the cultivar Torrens. Torrens yielded a transformation efficiency of 1.8%,using a modified Agrobacterium transformation method.This method was used to over-express genes encoding synthases for the important dietary fiber component,(1,3;1,4)-b-glucan(mixed-linkage glucan), primarily present in starchy endosperm cell walls. Over-expression of the Hv Csl F6 gene, driven by an endosperm-specific promoter,produced lines where mixed-linkage glucan content increased on average by 45%, peaking at 70% in some lines,with smaller increases in transgenic Hv Csl H1 grain. Transgenic Hv Csl F6 lines displayed alterations where grain had a darker color, were more easily crushed than wild type and were smaller. This was associated with an enlarged cavity in the central endosperm and changes in cell morphology,including aleurone and sub-aleurone cells. This work provides proof-of-concept evidence that mixed-linkage glucan content in hull-less barley grain can be increased by over-expression of the Hv Csl F6 gene, but also indicates that hull-less cultivars may be more sensitive to attempts to modify cell wall composition. | Wai Li Lim Helen M. Collins Rohan R. Singh Natalie A. J. Kibble Kuok Yap Jillian Taylor Geoffrey B. Fincher Rachel A. Burton | 2018 | Journal of Integrative Plant Biology2018，60，5： | 1 |
| 9 | Generation of dendritic cell–tumor cell hybrids by electrofusion for clinical vaccine application显示文摘 | Katrina T. Trevor Cathleen Cover Yvette W. Ruiz Emmanuel T. Akporiaye Evan M. Hersh Didier Landais Rachel R. Taylor Alan D. King Richard E. Walters | 2004 | Cancer Immunology Immunotherapy2004，，8： | 1 |
| 10 | Abscisic acid biosynthesis in tomato: regulation of zeaxanthin epoxidase and 9-cis-epoxycarotenoid dioxygenase mRNAs by light/dark cycles, water stress and abscisic acid显示文摘 | Andrew J. Thompson Alison C. Jackson Rachel A. Parker David R. Morpeth Alan Burbidge Ian B. Taylor | 2000 | Plant Molecular Biology2000，，6： | 1 |
| 11 | Abscisic acid biosynthesis in tomato: regulation of zeaxanthin epoxidase and 9-cis-epoxycarotenoid dioxygenase mRNAs by light/dark cycles, water stress and abscisic acid显示文摘 | Andrew J. Thompson Alison C. Jackson Rachel A. Parker David R. Morpeth Alan Burbidge Ian B. Taylor | 2000 | Plant Molecular Biology2000，，6： | 1 |
| 12 | Healthcare staff well-being and use of support services during COVID-19:a UK perspective显示文摘Background The COVID-19 pandemic has drastically increased demands on healthcare workers(HCWs)leaving them vulnerable to acute psychological distress,burnout and post-traumatic stress.In response,supportive services in a central London hospital mobilised mental health support specifically for HCWs.Aims This rapid evaluation assessed HCW psychological welfare during the acute phase of the COVID-19 pandemic and their use of supportive services made available.Methods During the acute phase of COVID-19(April to May 2020)all staff working for the hospital were invited to complete an online survey assessing well-being(self-rated health,moral distress exposure,symptoms of burnout and psychological distress)and use of available supportive services(awareness of,use and perceived helpfulness).Associations among personal characteristics and psychological well-being were explored using correlations and linear regression.Results A total of 1127 staff participated in the rapid evaluation.On average,psychological distress was high(mean(SD):22(7.57))regardless of role,with 84%of this sample scoring above the general population mean(14.5).Nearly half of the sample reported feeling emotionally drained and a profile emerged displaying higher levels of psychological distress and burnout in those who were younger and exposed to morally distressing situations,with this group also exhibiting greater support service use.Greater levels of burnout were associated with increased psychological distress when controlling for personal factors.During this acute phase of the pandemic,majority of staff used at least one service and rated it as helpful.Conclusion HCWs experienced high levels of psychological distress requiring continued support as the COVID-19 pandemic evolved.Although HCWs were aware of supportive services,uptake varied.In order to mitigate the risk of burnout and post-traumatic stress,long-term,effective strategies that facilitate staff accessing support are urgently required. | Anika R Petrella Luke Hughes Lorna A Fern Lisa Monaghan Benjamin Hannon Adam Waters Rachel M Taylor | 2021 | General Psychiatry2021，34，3： | 0 |
| 13 | A proposed framework for accelerating technology trajectories in agriculture:a case study in China显示文摘Precision agriculture(PA) technologies have great potential for promoting sustainable intensification of food production, ensuring targeted delivery of agricultural inputs, and hence food security and environmental protection. The benefits of PA technologies are applicable across a broad range of agronomic, environmental and rural socio-economic contexts globally. However, farmer and land-manager adoption in low to middle income countries has typically been slower than that observed in more affluent countries. China is currently engaged in the process of agricultural modernisation to ensure food security for its 1.4 billion population and has developed a portfolio of policies designed to improve food security,while simultaneously promoting environmental protection.Particular attention has been paid to the reduction of agricultural inputs such as fertilisers and pesticides. The widespread adoption of PA technologies across the Chinese agricultural landscape is central to the success of these policies. However, socio-economic and cultural barriers, farm scale,(in particular the prevalence of smaller family farms) and demographic changes in the rural population,(for example, the movement of younger people to the cities) represent barriers to PA adoption across China. A framework for ensuring an acceptable and accelerated PA technology trajectory is proposed which combines systematic understanding of farmer and end-user priorities and preferences for technology design throughout the technology development process, and subsequent end-user requirements for implementation(including demonstration of economic and agronomic benefits, andknowledge transfer). Future research will validate the framework against qualitative and quantitative socioeconomic, cultural and agronomic indicators of successful,or otherwise, PA implementation. The results will provide the evidence upon which to develop further policies regarding how to secure sustainable food production and how best to implement PA in China, as well as practical recommendations for optimising end-user uptake. | Beth CLARK Glyn D.JONES Helen KENDALL James TAYLOR Yiying CAO Wenjing LI Chunjiang ZHAO Jing CHEN Guijun YANG Liping CHEN Zhenhong LI Rachel GAULTON Lynn J.FREWER | 2018 | Frontiers of Agricultural Science and Engineering2018，5，4： | 0 |
| 14 | A comparative review of the state and advancement of Site-Specific Crop Management in the UK and China显示文摘Precision agriculture, and more specifically Site-Specific Crop Management(SSCM), has been implemented in some form across nearly all agricultural production systems over the past 25 years. Adoption has been greatest in developed agricultural countries. In this review article, the current situation of SSCM adoption and application is investigated from the perspective of a developed(UK) and developing(China) agricultural economy. The current state-of-the art is reviewed with an emphasis on developments in position system technology and satellite-based remote sensing. This is augmented with observations on the differences between the use of SSCM technologies and methodologies in the UK and China and discussion of the opportunities for(and limitations to)increasing SSCM adoption in developing agricultural economies. A particular emphasis is given to the role of socio-demographic factors and the application of responsible research and innovation(RRI) in translating agritechnologies into China and other developing agricultural economies. Several key research and development areas are identified that need to be addressed to facilitate the delivery of SSCM as a holistic service into areas with low precision agriculture(PA) adoption. This has implications for developed as well as developing agricultural economies. | Zhenhong LI James TAYLOR Lynn FREWER Chunjiang ZHAO Guijun YANG Zhenhai LI Zhigang LIU Rachel GAULTON Daniel WICKS Hugh MORTIMER Xiao CHENG Chaoqing YU Zhanyi SUN | 2019 | Frontiers of Agricultural Science and Engineering2019，6，2： | 0 |
| 15 | 去甲肾上腺素激活星形胶质细胞内核膜上的β1-肾上腺素能受体显示文摘去甲肾上腺素对星形胶质细胞的代谢、神经保护和免疫调节功能有强大的影响。直到最近,去甲肾上腺素的所有作用尚被认为是由仅存在于细胞质膜的受体介导的。然而,最近对心肌细胞的研究已经确定定位于细胞内膜(包括高尔基体和内核膜)的肾上腺素能受体,并表明去甲肾上腺素可以通过转运蛋白介导的摄取而作用于这些受体。我们最近发现了一种高容量去甲肾上腺素转运蛋白有机阳离子转运蛋白3(OCT3)。该转运蛋白密集定位于星形胶质细胞的外核膜,这表明肾上腺素能信号传导也可能发生在这些细胞的内核膜上。本研究证实:使用免疫荧光和蛋白质印迹技术显示β1-肾上腺素受体定位于星形胶质细胞内核膜;关键的肾上腺素能信号通路组分存在于星形胶质细胞核中;且OCT3和其他儿茶酚胺转运蛋白于星形胶质细胞质膜和核膜均表达。为了测试核膜β1-肾上腺素能受体的功能,我们使用荧光生物传感器实时监测星形胶质细胞核中的蛋白激酶A(PKA)活性。用去甲肾上腺素处理星形胶质细胞会导致核区室中PKA活性的快速增加。用儿茶酚胺摄取抑制剂预处理星形胶质细胞可阻断去甲肾上腺素诱导的核PKA活性的快速增加。这些研究首次记录了任何中枢神经系统细胞核膜上的功能性肾上腺素能受体,揭示了去甲肾上腺素可能直接影响核过程的新机制。这种机制可能与先前描述的去甲肾上腺素的神经保护、代谢和免疫调节作用有关。 | Kelsey C Benton Daniel S Wheeler Beliz Kurtoglu Mahshid Bagher Zadeh Ansari Daniel P Cibich Dante A Gonzalez Matthew R Herbst Saema Khursheed Rachel C Knorr Doug Lobner Jenree G Maglasang Kayla E Rohr Analisa Taylor Robert C Twining Paul JWitt Paul J Gasser 杜一星(编译) | 2022 | 神经损伤与功能重建2022，17，7： | 0 |
| 16 | 点火显示文摘你可能会说,你孤身前行无人可以依靠你的生活岌岌可危,像把上了膛的枪你正在发抖。 | Rachel Taylor BillyBudd | 2018 | 疯狂英语(新悦读)2018，0，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员