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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension显示文摘 | Paolo Palatini Giulio Ceolotto Fabio Ragazzo Francesca Dorigatti Francesca Saladini Italia Papparella Lucio Mos Giuseppe Zanata Massimo Santonastaso | 2009 | Journal of Hypertension2009，，8： | 1 |
| 3 | Hyperparathyroidism can be useful in the identification of primary aldosteronism due to al- dosterone-producing adenoma显示文摘 | Rossi GP Ragazzo F Seccia TM | 2012 | Hypertension2012，60，43： | 1 |
| 4 | Montelukast and airway remodeling in children with chronic persistent asthma: an open study 显示文摘 | Pifferi M Caramella D Ragazzo V De Marco E Pietrobelli A Boner AL | 2004 | Pediatr Allergy Immunol2004，15，5： | 1 |
| 5 | Eosinophile cationic protein in infants with respiratory syncytial virus bronchiolitis:predictive value for subsequent development of persistent wheezing显示文摘 | Pifferi M Ragazzo V Garamella D | 2001 | Pedistr Pulmonl2001，31，5： | 1 |
| 6 | Neurologic side effects of flunarizine显示文摘 | De Melo-Souza SE Ragazzo PC | 1989 | Neurology1989，39，： | 1 |
| 7 | Toward a delaware common law of closely held corporations显示文摘 | RAGAZZO R A | 1999 | Washington University Law Quarterly1999，77，： | 1 |
| 8 | Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing 显示文摘 | Pifferi M Ragazzo V Caramella D | 2001 | Pediatric Pulmonol2001，31，6： | 1 |
| 9 | Montelukast and airway remodeling in children with chronic persistent asthma: an open study 显示文摘 | PIFFERI M CARAMELLA D RAGAZZO V | 2004 | Pediatr Allergy Immunol2004，15，5： | 1 |
| 10 | Identification of alcoholic beverages by coupling gas chromatography and electronic nose显示文摘 | Ragazzo J A Chalier P Crouzet J | 2001 | Food Flavours and Chemistry2001，10，： | 1 |
| 11 | Eosinophil cationic pro- tein in infants with respiratory syneytial virus bronchiolitis: pre- dictive value for subsequent development of persistent wheezing 显示文摘 | Pifferi M Ragazzo V Caramella D etal | 2001 | Pediatr Pulmonol2001，31，6： | 1 |
| 12 | Transient Regime Duration in Continuous - time Neural Networks with Delay显示文摘 | PAKDAMAN K GROTTA - RAGAZZO C MALTA C P | 1998 | Physical Review E1998，58，3： | 1 |
| 13 | Low-density areas on high-resolution computed tomograms in chronic pediatric asthma显示文摘 | Pifferi M Caramella D Ragazzo V | 2002 | J Pediatr2002，141，1： | 1 |
| 14 | Bilateral Globus Pallidus Externus Deep Brain Stimulation (GPe- DBS) for the Treatment of Tourette Syndrome: An Ongoing Prospective Controlled Study显示文摘 | Filho OV Ragazzo PC Silva DJ at al | 2007 | Stereotaet Funet Neurosurg2007，85，： | 1 |
| 15 | Age-related macular degeneration: insights into in- flammatory genes显示文摘 | Cascella R Ragazzo M Strafella C Missiroli F Borgiani P Ange- lucci F | 2014 | J Ophthalmo12014，2014，58： | 1 |
| 16 | Clinical usefulness of slow pathway ablation in patients with both paroxysmal atrioventricular nodal reentrant tachycardia and atrial fibrillation显示文摘 | Pietro Delise Lorella Gianfranchi Nelly Paparella Michele Brignole Carlo Menozzi Sakis Themistoclakis Roberta Mantovan Aldo Bonso Leonardo Corò Alessandro Vaglio Monica Ragazzo Paolo Alboni Antonio Raviele | 1997 | The American Journal of Cardiology1997，，10： | 1 |
| 17 | Transthoracic and transesophageal echocardiographic indices predictive of sinus rhythm maintenance after cardioversion of atrial fibrillation : an echocardiographic study during direct current shock 显示文摘 | De Piccoli B Rigo F Ragazzo M | 2001 | Echoeardiography2001，18，7： | 1 |
| 18 | 家具可以“随意”些显示文摘还记得学生时代这个经典的命题作文吗?老师用粉笔在黑板上画了一个圆圈,大学生认为太简单而不屑回答,高中生回答是零,初中生说是英语字母"o",而小学生的回答最有趣:"是太阳!""是铁环!""是皮球!""是汤圆!""是唱歌时的嘴巴!"……读完请你以"想像力……"为题,写一篇文章。 | Damien Gernay Daniele Ragazzo TORAFU ARCHITECTS Nendo Lukas Wegwerth Nacho Carbonell Siba Sahabi 彭佳 | 2016 | 现代装饰(家居)2016，0，11： | 0 |
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