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| 1 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | Non-coding landscapes of colorectal cancer显示文摘For two decades Vogelstein's model has been theparadigm for describing the sequence of molecular changes within protein-coding genes that would lead to overt colorectal cancer(CRC). This model is now too simplistic in the light of recent studies, which have shown that our genome is pervasively transcribed in RNAs other than m RNAs, denominated non-coding RNAs(nc RNAs). The discovery that mutations in genes encoding these RNAs [i.e., micro RNAs(mi RNAs), long non-coding RNAs, and circular RNAs] are causally involved in cancer phenotypes has profoundly modified our vision of tumour molecular genetics and pathobiology. By exploiting a wide range of different mechanisms, nc RNAs control fundamental cellular processes, such as proliferation, differentiation, migration, angiogenesis and apoptosis: these data have also confirmed their role as oncogenes or tumor suppressors in cancer development and progression. The existence of a sophisticated RNA-based regulatory system, which dictates the correct functioning of protein-coding networks, has relevant biological and biomedical consequences. Different mi RNAs involved in neoplastic and degenerative diseases exhibit potential predictive and prognostic properties. Furthermore, the key roles of nc RNAs make them very attractive targets for innovative therapeutic approaches. Several recent reports have shown that nc RNAs can be secreted by cells into the extracellular environment(i.e., blood and other body fluids): this suggests the existence of extracellular signalling mechanisms, which may be exploited by cells in physiology and pathology. In this review, we will summarize the most relevant issues on the involvement of cellular and extracellular nc RNAs in disease. We will then specifically describe their involvement in CRC pathobiology and their translational applications to CRC diagnosis, prognosis and therapy. | Marco Ragusa Cristina Barbagallo Luisa Statello Angelo Giuseppe Condorelli Rosalia Battaglia Lucia Tamburello Davide Barbagallo Cinzia Di Pietro Michele Purrello | 2015 | World Journal of Gastroenterology2015，21，41： | 6 |
| 3 | Combining independent studies of diagnostic fluorodcoxyglucosc positron-emission tomography and computed tomography in mediastinal lymph node staging for non-small cell lung cancer显示文摘 | Alongi F Ragusa P Montemaggi P | 2006 | Tumori2006，92，4： | 1 |
| 4 | Growth of sulfate-reducing bacteria under acidic conditions in an up flow anaerobic bioreactors as a treatment system for acid mine drainage 显示文摘 | Philip Eiliott Santo Ragusa David Catcheside | 1998 | WatRes1998，32，12： | 1 |
| 5 | 2013, Spillovers from high - skill consumption to low - skill labor markets 显示文摘 | MAZZOLARI F RAGUSA G | 2013 | Review of Economics and Sta- tistiesm2013，，1： | 1 |
| 6 | Indicators of biofilm development and activity in constructed wetlands microcosms显示文摘 | Ragusa S R McNevin D Qasem S | 2004 | Water Research2004，38，： | 1 |
| 7 | Specific alterations of microRNA transcriptome and global network structure in colorectal carcinoma after cetuximab treatment显示文摘 | Ragusa M Majorana A Statello L | 2010 | Mol Cancer Ther2010，9，12： | 1 |
| 8 | A computationally effective dynamic hysteresis model taking into account skin effect in magnetic laminations 显示文摘 | Barriere 0 D L Ragusa C Appino C | 2014 | Physica B: Condensed Matter2014，435，15： | 1 |
| 9 | Interrelationships between biological,chemical,and physical processes as an analog to clogging in aquifer storage and recovery (asr) wells显示文摘 | Rinck-Pfeiffer S Ragusa S Sztajnbok P | 2000 | Water Research2000，43，7： | 1 |
| 10 | Interior estimates in Morrey spaces for strong solutions to nondivergence form equations with discontinuous coefficients显示文摘 | Fazio G Di Ragusa M A | 1993 | J Funct Anal1993，112，： | 1 |
| 11 | Generation of conditional Mef2cloxP/loxP mice for temporal- and tissue-specific analyses显示文摘 | Vong LH Ragusa M J Schwarz JJ | 2005 | Genesis2005，43，1： | 1 |
| 12 | Growth of sulfate-reducing bacteria under acidic conditions in an upflow anaerobic bioreactor as a treatment system for acid mine drainage显示文摘 | Phillip Elliott Santo Ragusa David Cateheside | | 0，，12： | 1 |
| 13 | Combining independent studies of diagnostic fluorodeoxyglucose positron-emission tomography and computed tomography in mediastinal lymph node staging for nonsmall cell lung cancer显示文摘 | Alongi F Ragusa P Montemaggi P | 2006 | Tumori2006，92，4： | 1 |
| 14 | Pulmonary seques-tration supplied by giant aneurysmal aortic branch 显示文摘 | Ragusa M Vannucci J Lenti M | 2010 | Ann Thorac Surg2010，89，2： | 1 |
| 15 | Forefoot morphotype study and planning method for forefoot osteotomy 显示文摘 | Maestro M Besse JL Ragusa M | 2003 | Foot Ankle Clin2003，8，4： | 1 |
| 16 | Predicting loss in mag- netic steels under arbitrary induction waveform and with minor hysteresis loops显示文摘 | BARBISIO E FIORILLO F RAGUSA C | 2004 | IEEE Trans on Magnetics2004，40，4： | 1 |
| 17 | A robust approach to high-speed navigation for unrehearsed desert terrain显示文摘 | Urmson C Ragusa C Ray A D | 2006 | Journal of Field Robotics2006，23，8： | 1 |
| 18 | Chest wall stabilization with synthestic reabsorbable matertial显示文摘 | Puma F Ragusa M Daddi G | 1992 | Ann Thorac Surg1992，53，： | 1 |
| 19 | Interior estimates in Morrey spaces for strong solutions to nondivergence from equations with discontinuous coefficients显示文摘 | DIFAZIO G RAGUSA M A | 1993 | J Funct Anal1993，112，： | 1 |
| 20 | Spillovers from high-skill consumption to low-skill labor markets显示文摘 | Mazzolari F Ragusa G | 2007 | IZA Working Paper2007，，： | 1 |
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