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| 1 | Hepatitis B virus genotypes in southwest Iran: Molecular, serological and clinical outcomes显示文摘AIM: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. METHODS: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed. RESULTS: Genotype D was the only type of HBV foundin different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV- infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and -negative individuals (P = 0.24). CONCLUSION: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease. | Anahita Mojiri Abbas Behzad-Behbahani Mehdei Saberifirozi Maryam Ardabili Mahmood Beheshti Marjan Rahsaz Mehrdad Banihashemi Negar Azarpira Bita Geramizadeh Baharak Khadang Afsaneh Moaddeb Mojgan Ghaedi Tahereh Heidari Ardeshir Torab Alireza Salah Saeid Amirzadeh Zahra Jowkar Davood Mehrabani Samad Amini-Bavil-Olyaee Mohammad Ali Dehyadegari | 2008 | World Journal of Gastroenterology2008，14，10： | 4 |
| 2 | Comparison of the ex-pression of cell adhesion molecule markers (E-cadherin and synde-can-1) between young and older age patients with gastric carcino-ma显示文摘 | Geramizadeh B Adeli OA Rahsaz M | 2010 | J Gastrointest Cancer2010，42，3： | 1 |
| 3 | Histologic differentiation ofhepatocellular carcinoma from adenocarcinoma by simple panel:evaluation of the pitfalls显示文摘 | Geramizadeh B Boub R Rahsaz M | 2007 | Indian J Pathol Microbiol2007，50，3： | 1 |
| 4 | Association between tacrolimus concentration and genetic polymorphisms of CYPBA5 and ABCB1 during the early stage after liver transplant in an Iranian population显示文摘 | Rahsaz M Azarpira N Nikeghbalian S | 2012 | Exp Clin Transplant2012，10，1： | 1 |
| 5 | Useful markers for differential diagnosis of oncocytoma,ehro mophobe renal cell carcinoma and conventional renal cell carcinoma显示文摘 | Geramizadeh B Ravanshad M Rahsaz M | 2008 | IndianJ Pathol Microbiol2008，51，2： | 1 |
| 6 | Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma 显示文摘 | Geramizadeh B Ravanshad M Rahsaz M | 2008 | Indian J Pathol Microbiol2008，51，2： | 1 |
| 7 | Association between tacrolimus concentration and genetic polymorphisms of CYP3A5 and ABCB1 during the early stage after liver transplant in an Iranian population显示文摘 | Rahsaz M Azarpira N Nikeghbalian S | | 0，，01： | 1 |
| 8 | Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma 显示文摘 | Geramizadeh B Ravanshad M Rahsaz M | 2008 | Indian J Pathol Microbial2008，51，2： | 1 |
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