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| 1 | Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population显示文摘 | Zaigui Wu Zeshan You Cai Zhang Zhuyu Li Xiumei Su Xiuming Zhang Yinguang Li Raivo Uibo | 2011 | Clinical and Developmental Immunology2011，，： | 1 |
| 2 | The culiar touch of the East: Reading the post-war landscapes of the Finnish Orthodox Church显示文摘 | RAIVO P J | 2002 | Social&Cultural Geography2002，3，1： | 1 |
| 3 | Production-based and consumption-based national greenhouse gas inventories: An implication for Estonia显示文摘 | Olga Gavrilova Raivo Vilu | 2012 | Ecological Economics2012，，： | 1 |
| 4 | Meta‐analysis of microRNA expression in lung cancer显示文摘 | Urmo V?sa T?nu Vooder Raivo Kolde Jaak Vilo Andres Metspalu Tarmo Annilo | 2012 | Int J Cancer2012，，12： | 1 |
| 5 | Exercise training with dietary counseling increaSes mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance显示文摘 | Mika V Sirkka A Raivo P | 2008 | Endocrine Disorders2008，8，8： | 1 |
| 6 | A Life Cy- cle Environmental Impact Assessment of Oil Shale Produced and Consumed in Estonia 显示文摘 | Olga Gavrilova Raivo Vilu Leo Vallner | 2010 | Resources Conservation and Recycling2010，55，： | 1 |
| 7 | Screening for celiac disease in Down's syndrome patients revealed cases of subtotal villous atrophy without typical for celiac disease HLA-DQ and tissue transglutaminase antibodies显示文摘瞄准:为了在 134 karyotyped 象 CD 标记抗体和危险性 HLA-DQ haplotypes 一样调查乳糜泻(CD ) 的流行,击倒的症候群(DS ) 病人。方法:免疫球蛋白 A (IgA ) 和 G (IgG ) 打反麦胶蛋白质抗体(统帅) ,有畿尼猪和人的来源的抗原的 IgA 类型反织物 transglutaminase (tTG ) 抗体(anti-tTG ) 被间接免疫被连接酶的免疫吸着剂试金和肌内膜抗体(EMA ) 决定荧光测试。HLA-DQA1 *0501 /DQB1 *0201 (DQ2 ) 被聚合酶链反应揭示。乳糜泻被修订 ESPGHAN 标准诊断。结果:41% DS 病人有统帅,有畿尼猪抗原的 6.0% IgA anti-tTG,和 3.0% IgA EMA (为有人的 tTG 的 anti-tTG 积极的所有) 。覆有一层绒毛的萎缩从同意了小肠活体检视的 9 个 DS 病人在 5 被发现的小计。他们之一有 DQA1 *0501 /DQB1 *0201 和 anti-tTG 和 EMA 即为 CD 标记典型(这个盒子也完成了 ESPGHAN 诊断标准) ,但是另外的四缺乏这些标记。最可能也有的三个活体检视得非的 DS 病人 CD 因为 DQA1 *0501 /DQB1 *0201 和 IgA anti-tTG (EMA ) 被检测。因此,在我们的 DS 病人人口之中的 CD 的流行是 3.0%( 信心间隔的 95 %[CI ] :0.1-5.9%) 。结论:我们在 DS 病人之中证实 CD 的增加的频率。另外,我们与小计揭示了病人的亚群覆有一层绒毛的萎缩但是没有为 CD 免疫学的和基因标记的特征。这些盒子是否代表 CD (与不正常的免疫致病) 或某另外的有免疫力的肠病,要求进一步的调查。 | Oivi Uibo Kaupo Teesalu Kaja Metsküla Tiia Reimand Riste Saat Tarvo Sillat Koit Reimand Tiina Talvik Raivo Uibo | 2006 | World Journal of Gastroenterology2006，12，9： | 1 |
| 8 | High urban population density of birds reflects their timing of urbanization显示文摘 | Anders Pape M?ller Mario Diaz Einar Flensted-Jensen Tomas Grim Juan Diego Ibá?ez-álamo Jukka Jokim?ki Raivo M?nd Gábor Markó Piotr Tryjanowski | 2012 | Oecologia2012，，3： | 1 |
| 9 | Environmental risks and problems of the optimal management of an oil shale semi - coke and ash landfill in Kohtla - J? rye, Estonia 显示文摘 | Leo V Olga G Raivo V | 2015 | Science of The Total Environment2015，524，： | 1 |
| 10 | Primary biliary cirrhosis: a multi‐faced interactive disease involving genetics, environment and the immune response显示文摘 | Raivo Uibo Kai Kisand Chen‐Yen Yang M. Eric Gershwin | 2012 | APMIS2012，，11： | 1 |
| 11 | Celiac disease:a model disease for gene-environment interaction显示文摘Celiac sprue remains a model autoimmune disease for dissection of genetic and environmental influences on disease progression.The 2010 Congress of Autoimmunity included several key sessions devoted to genetics and environment.Several papers from these symposia were selected for in-depth discussion and publication.This issue is devoted to this theme.The goal is not to discuss genetic and environmental interactions,but rather to focus on key elements of diagnosis,the inflammatory response and the mechanisms of autoimmunity. | Raivo Uibo Zhigang Tian M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，2： | 0 |
| 12 | Celiac disease in patients with type 1 diabetes:a condition with distinct changes in intestinal immunity?显示文摘Two common chronic childhood diseases-celiac disease(CD)and type 1 diabetes(T1D)-result from complex pathological mechanisms where genetic susceptibility,environmental exposure,alterations in intestinal permeability and immune responses play central roles.In this study,we investigated whether these characteristics were universal for CD independently of T1D association.For this purpose,we studied 36 children with normal small-bowel mucosa and 26 children with active CD,including 12 patients with T1D.In samples from the small-bowel mucosa,we detected the lowest expression of tight junction protein 1(TJP1)mRNA in CD patients with T1D,indicating an increase in intestinal permeability.Furthermore,these samples displayed the highest expression of forkhead box P3(FoxP3)mRNA,a marker for regulatory T cells,as compared with other patient groups.At the same time,serum levels of IgA antibodies specific for the CD-related antigens deamidated gliadin and tissue transglutaminase(tTG)were the highest in CD patients with T1D.In contrast,no significant differences were found in IgA or IgG antibodies specific for bovine beta-lactoglobulin or Bifidobacterium adolescentis DSM 20083-derived proteins.There were also no differences in the transamidating activity of serum autoantibodies between patients and control individuals.Our results show that patients with T1D and newly detected CD exhibit severely altered intestinal permeability,strong local immune activation and increased immunoregulatory mechanisms in the small bowel.Further study is required to determine whether these extreme changes in this CD subgroup are due to some specific environmental factors(virus infections),unknown genetic effects or autoimmune reactions to antigenic targets in intracellular tight junctions. | Raivo Uibo Marina Panarina Kaupo Teesalu Ija Talja Epp Sepp Meeme Utt Marika Mikelsaar Kaire Heilman Oivi Uibo Tamara Vorobjova | 2011 | Cellular & Molecular Immunology2011，8，2： | 0 |
| 13 | Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients显示文摘AIM: To investigate the densities of dendritic cells(DCs) and FOXP3+ regulatory T cells(Tregs) and their interrelations in the small bowel mucosa in untreated celiac disease(CD) patients with and without type 1 diabetes(T1D).METHODS: Seventy-four patients(45 female, 29 male, mean age 11.1 ± 6.8 years) who underwent small bowel biopsy were studied. CD without T1 D was diagnosed in 18 patients, and CD with T1 D was diagnosed in 15 patients. Normal small bowel mucosa was found in two T1 D patients. Thirty-nine patients(mean age 12.8 ± 4.9 years) with other diagnoses(functional dyspepsia, duodenal ulcer, erosive gastritis, etc.) formed the control group. All CD patients had partial or subtotal villous atrophy according to the Marsh classification: Marsh grade Ⅲa in 9, grade Ⅲb in 21 and grade Ⅲc in 3 cases. Thirty-nine patients without CD and 2 with T1 D had normal small bowel mucosa(Marsh grade 0). The densities of CD11c+, IDO+, CD103+, Langerin(CD207+) DCs and FOXP3+ Tregs were investigated by immunohistochemistry(on paraffin-embedded specimens) and immunofluorescence(on cryostat sections) methods using a combination of mono- and double-staining. Sixtysixserum samples were tested for Ig A-tissue transglutaminase(t TG) using a fully automated Eli ATM Celikey Ig A assay(Pharmacia Diagnostics, Freiburg, Germany). RESULTS: The density of CD11c+ DCs was significantly increased in CD patients compared with patients with normal mucosa(21.67 ± 2.49 vs 13.58 ± 1.51, P = 0.007). The numbers of FOXP3+ cells were significantly higher in CD patients(10.66 ± 1.50 vs 1.92 ± 0.37, P = 0.0002) and in patients with CD and coexisting T1D(8.11 ± 1.64 vs 1.92 ± 0.37, P = 0.002) compared with patients with normal mucosa. The density of FOXP3+ cells significantly correlated with the histologicalgrade of atrophic changes in the small bowel mucosa according to the March classification(r = 0.62; P < 0.0001) and with levels of Ig A antibody(r = 0.55; P < 0.0001). The densities of IDO+ DCs were significantly higher in CD patients(21.6 ± 2.67 vs 6.26 ± 0.84, P = 0.00003) and in patients with CD and coexisting T1D(19.08 ± 3.61 vs 6.26 ± 0.84, P = 0.004) compared with patients with normal mucosa. A significant correlation was identified between the densities of IDO+ DCs and FOXP3+ T cells(r = 0.76; P = 0.0001). The mean values of CD103+ DCs were significantly higher in CD patients(10.66 ± 1.53 vs 6.34 ± 0.61, P = 0.01) and in patients with CD and associated T1D(11.13 ± 0.72 vs 6.34 ± 0.61, P = 0.00002) compared with subjects with normal small bowel mucosa. The mean value of Langerin+ DCs was higher in CD patients compared with persons with normal mucosa(7.4 ± 0.92 vs 5.64 ± 0.46, P = 0.04).CONCLUSION: The participation of diverse DC subsets in the pathological processes of CD and the possible involvement of tolerogenic DCs in Tregs development to maintain intestinal immunological tolerance in CD patients are revealed. | Tamara Vorobjova Oivi Uibo Kaire Heilman Raivo Uibo | 2015 | World Journal of Gastroenterology2015，21，2： | 0 |
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