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| 1 | The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes显示文摘 | Bhakkiyalakshmi E Sireesh D Rajaguru P | 2014 | Pharmacol Res2014，，： | 1 |
| 2 | Quarterly real GDP estimates for China and ASEAN4 with a forecast evaluation显示文摘 | Abeysinghe T Rajaguru G | 2004 | Journal of Forecasting2004，23，： | 1 |
| 3 | Quarterly Real GDP Estimates for China and ASEAN4 with a Forecast Evaluation 显示文摘 | Abeysinghe Tilak Gulasekaran Rajaguru | 2004 | Journal of Forecasting2004，23，6： | 1 |
| 4 | The Long-run Determinants of Australian Income Inequality显示文摘 | Noel Gaston and Gulasekaran Rajaguru | 2009 | Economic Record2009，，3： | 1 |
| 5 | Thermal Resistance Time of Estuarine Fishes Etroplus Suratensis and Therapon Jarbua显示文摘 | Rajaguru S | 2002 | Journal of Thermal Biology2002，27，2： | 1 |
| 6 | Sources of variations between the inflation rates of Korea,Thailand and Indonesia during the post-1997 crisis显示文摘 | Reza Siregar and Gulasekaran Rajaguru | 2005 | Journal of Policy Modeling2005，，10： | 1 |
| 7 | Genotoxicity evaluation of polluted ground water in human peripheral blood lymphocytes using the comet assay显示文摘 | Rajaguru P Vidya L Baskarasethupathi B | 2002 | Mutat Res2002，517，123： | 1 |
| 8 | Temperature tolerance of some estuarine fishex显示文摘 | Rajaguru S Ramachandran S | 2001 | J therm Biol2001，26，： | 1 |
| 9 | Biodegradation of azo dyes in a sequential anaerobic-aerobic system显示文摘 | Rajaguru P Kalaiselvi K Palanivel M | 2000 | Applied Microbi-ology and Biotechnology2000，54，2： | 1 |
| 10 | Temperature tolerance of some estuarine fishes显示文摘 | Rajaguru S Ramachandran S | 2001 | Journal of Thermal Biology2001，26，1： | 1 |
| 11 | Genotoxicity evaluation of polluted ground water in human peripheral blood lymphocytes using the comet assay显示文摘 | Rajaguru P Vidya L Baskarasethupathi B | 2002 | Mutat Res2002，517，： | 1 |
| 12 | Temperature tolerance of some estuarine fishes 显示文摘 | Rajaguru S Ramachandran S | 2001 | Journal of Thermal Bi- ology2001，26，1： | 1 |
| 13 | Quarterly real GDP estimates for China and ASEAN4 with a forecast evaluation显示文摘 | Abeysinghe T Rajaguru G | | 0，，06： | 1 |
| 14 | Fabrication, characterization, in vitro drug release and glucose uptake activity of 14-deoxy,11, 12-didehydroandrographolide loaded polycaprolactone nanoparticles显示文摘Biodegradable polymer based novel drug delivery systems brought a considerable attention in enhancing the therapeutic efficacy and bioavailability of various drugs. 14-deoxy 11, 12-didehydro andrographolide(poorly water soluble compound) loaded polycaprolactone(nanoDDA) was synthesized using the solvent evaporation technique. Nano-DDA was characterized by scanning electron microscopy(SEM) and dynamic light scattering(DLS) studies. Fourier Transform InfraRed Spectroscopy(FTIR) was used to investigate the structural interaction between the drug and the polymer. Functional characterization of the formulation was determined using drug content, cellular uptake and in vitro drug release. 2-deoxy-D-[1-~3H] glucose uptake assay was carried out to assess the antidiabetic potential of nano-DDA in L6 myotubes.The nano-DDA displayed spherical shape with a smooth surface(252.898 nm diameter), zeta potential, encapsulation and loading efficiencies of -38.9 mV, 91.98 ± 0.13% and 15.09 ± 0.18% respectively. No structural alteration between the drug and the polymer was evidenced(FTIR analysis). Confocal microscopy studies with rhodamine 123 loaded polycaprolactone nanoparticles(Rh123-PCL NPs) revealed the internalization of Rh123-PCL NPs in a time dependent manner in L6 myoblasts. A dose dependent increase in glucose uptake was observed for nano-DDA with a maximal uptake of 108.54 ± 1.42% at 100 nM on L6 myotubes, thereby proving its anti-diabetic efficacy. A biphasic pattern of in vitro drug release demonstrated an initial burst release at 24 h followed by a sustained release for up to 11 days. To conclude,our results revealed that nano-DDA formulation can be a potent candidate for antidiabetic drug delivery. | Nagalakshmi Kamaraj Pooja Yashwanthi Rajaguru Praveen kumar Issac Sujatha Sundaresan | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，4： | 1 |
| 15 | Ethanol extract of Gymnema montanum leaves reduces glycopmtein components in ex-perimental diabetes显示文摘 | RAMKUMAR K M RAJAGURU P LATHA M | 2007 | Nutrition Research2007，27，： | 1 |
| 16 | In vitro cytotoxicity of Gymnema montanum in human leukaemia HL ‐60 cells; induction of apoptosis by mitochondrial membrane potential collapse显示文摘 | K. M. Ramkumar C. Manjula B. Elango K. Krishnamurthi S. Saravana Devi P. Rajaguru | 2013 | Cell Prolif2013，，3： | 1 |
| 17 | Geno-toxic ity evaluation of polluted ground water in humanperipheral blood lymphocytes using the comet assay显示文摘 | Rajaguru P Vidya L Baskarasethupathi B | 2002 | Mutation Research2002，517，12： | 1 |
| 18 | Assess-ment of heavy metal contents in the ambient air of theCoimbatore City, Tamilnadu, India显示文摘 | Vijayanand C Rajaguru P Kalaiselvi K | 2008 | Journal of Haz-ardous Materials2008，160，2： | 1 |
| 19 | Characterization of a new MOSFET detector configuration for in vivo skin dosimetry显示文摘 | Scalchi P Francescon P Rajaguru P | | 0，，06： | 1 |
| 20 | Quarterly real GDP es- timates for China and ASEAN4 with a forecast evaluation 显示文摘 | ABEYSINGHE T RAJAGURU G | 2004 | Journal of Forecasting2004，23，6： | 1 |
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