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| 1 | Control of autoimmune arthritis by herbal extracts and their bioactive components显示文摘Autoimmune diseases such as rheumatoid arthritis (RA) cause significant morbidity and loss of productivity. Many potent conventionally used drugs are available for these diseases, but their prolonged use is accompanied by severe adverse effects besides a high cost.Therefore, there is an unmet need for effective but less expensive medications for RA and other autoimmune diseases. Natural plant products belonging to the traditional systems of medicine, such as the traditional Chinese medicine and Indian Ayurvedic medicine, offer a vast and promising resource in this regard. However, herbal medicinal products are often poorly characterized for their composition as well as mechanisms of action. We review here the results of our systematically performed studies aimed at defining the anti-arthritic activity of three herbal extracts, namely, modified Huo-luo-xiao-ling dan (HLXL), Celastrus aculeatus Merr., and polyphenolic fraction of green tea (Camellia sinensis), as well as a purifiedcompound Celastrol, a bioactive component of Celastrus. Specifically, we examined the effects of these herbal products on the immunological, biochemical and molecular biological effector pathways in autoimmune arthritis. We have also reviewed here related studies on these herbal products by other investigators. Taken together, we suggest further testing of these herbal products in RA patients. | Shivaprasad H.Venkatesha Brian Astry Siddaraju M.Nanjundaiah Hong R.Kim Rajesh Rajaiah Yinghua Yang Li Tong Hua Yu Brian M.Berman Kamal D.Moudgil | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，2： | 2 |
| 2 | Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses显示文摘 | Venkatesha SH Yu H Rajaiah R | 2011 | J Biol Chem2011，286，15： | 1 |
| 3 | Heat-shock proteins can promote as well as regulate autoimmunity 显示文摘 | Rajaiah R Moudgil KD | 2009 | Autoimmun Rev2009，8，5： | 1 |
| 4 | Comparison of immunogenicity, protective efficacy of single and cocktail DNA vaccine of Brugia malayi abundant larval transcript (ALT-2) and thioredoxin peroxidase (TPX) in mice显示文摘 | Setty Balakrishnan Anand Vadivel Murugan Prince Rajaiah Prabhu Veerabhadran Anandharaman Maryada Venkata Rami Reddy Perumal Kaliraj | 2008 | Acta Tropica2008，，2： | 1 |
| 5 | New and practical synthesis of 1,4-dihydrobenzopyranopyrazoles显示文摘 | Chandrasekhar S Rajaiah G Srihari P | 2001 | Tetrahedron Lett2001，42，： | 1 |
| 6 | Heat -shock proteins can promote as well as regulate autoimtnunity 显示文摘 | RAJAIAH R MOUDHIL K D | 2009 | Autoimmun Rev2009，8，5： | 1 |
| 7 | Suppression of Ongoing Experimental Arthritis by a Chinese Herbal Formula (Huo-Luo-Xiao-Ling Dan) Involves Changes in Antigen-Induced Immunological and Biochemical Mediators of Inflammation显示文摘 | Ying-Hua Yang Rajesh Rajaiah David Y.-W Lee Zhongze Ma Hua Yu Harry H. S. Fong Lixing Lao Brian M. Berman Kamal D. Moudgil | 2010 | Evidence-Based Complementary and Alternative Medicine2010，，： | 1 |
| 8 | Structures with seismietive variable stiffness single/Multiple tuned mass dampers显示文摘 | Satish Naga rajaiah Ertan Sonmez | 2007 | Journal of Structural En- gineering2007，133，1： | 1 |
| 9 | Interleu-kin-27and interferon-gamma are involved in regulation ofautoimmune arthritis显示文摘 | Rajaiah R Puttabyatappa M Polumuri SK | 2011 | J Biol Chem2011，286，14： | 1 |
| 10 | Topical dermal application of essential oils attenuates the severity of adjuvant arthritis in Lewis rats显示文摘 | Komeh-Nkrumah SA Nanjundaiah SM Rajaiah R | 2012 | Phytotherapy Research2012，26，1： | 1 |
| 11 | Heat-shock proteins can promote as well as regulate autoimmunity 显示文摘 | Rajaiah R Moudgil KD | 2009 | Autoimmun Rev2009，8，5： | 1 |
| 12 | Nicotine-induced differential modulation of autoimmune arthritis in the Lewis rat involves changes in interleukin 17 and anti-cyclic citrullinated peptide antibodies显示文摘 | Yu H Yang Y H Rajaiah R Moudgil K D | 2011 | Arthritis Rheum2011，63，： | 1 |
| 13 | Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses 显示文摘 | Venkatesha SH Yu H Rajaiah R | 2011 | J Biol Chem2011，286，15： | 1 |
| 14 | Interleukin-27 and interferon-gamma are involved in regulation of autoimmune arthri- tis 显示文摘 | Rajaiah R Puttabyatappa M Polumuri SK | 2011 | J Biol Chem2011，286，4： | 1 |
| 15 | Interleukin-27 and interferon-gamma are involved in regulation of autoimmune arthritis显示文摘 | Rajaiah R Puttabyatappa M Polumuri SK | 2011 | J Biol Chem2011，286，： | 1 |
| 16 | Celastrus- derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses显示文摘 | Venkatesha SH Yu H Rajaiah R | 2011 | Biol Chem2011，286，15： | 1 |
| 17 | Green tea protects rats against autoimmune arthritis by modulating disease-related immune events显示文摘 | Hong Ro Kim Rajesh Rajaiah Qing-Li Wu | 2008 | Journal of Nutrition2008，138，11： | 1 |
| 18 | Heat-shock proteins can promote as well as regulate autoimmunity显示文摘 | Rajaiah R Moudgil KD | | 0，，： | 1 |
| 19 | Copper(11) complexes containing a CuN4 02 coordi- nation sphere, assembled via pyridine - imine - amide coordination : Synthesis, structure and properties 显示文摘 | Satyanarayan Bal Jally Pushpara-u Nimma Rajaiah Sangeetha | 2000 | Transition Metal Chemistry2000，25，： | 1 |
| 20 | Nicotine-induced differential modulation of autoimmune arthritis in the Lewis rat involves changes in interleukin-17 and anti-cyclic citrullinated peptide antibodies显示文摘 | Yu H Yang YH Rajaiah R | | 0，，： | 1 |
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