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| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | Epigenetic basis of Alzheimer disease显示文摘Alzheimer disease(AD)is the primary form of dementia that occurs spontaneously in older adults.Interestingly,the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD.In this review,we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD.The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD. | Angeles C Tecalco-Cruz JosuéO Ramírez-Jarquín María E Alvarez-Sánchez Jesus Zepeda-Cervantes | 2020 | World Journal of Biological Chemistry2020，11，2： | 4 |
| 3 | Effect of a bacterial inoculum and additive on dry matter in situ degradability of sugarcane silage显示文摘The objective of this study was to evaluate the effect of adding a bacterial inoculum and a handmade additive to sugarcane silage(SCS) on the in situ digestibility of dry matter(DM). The treatments were: T1) sugarcane silage(SCS) and T2) sugarcane silage with 1% inoculum and 1% additive(SCS+). The bacterial inoculum consisted of 10.0% molasses, 1.0% yogurt, 5.0% chicken manure, 0.5% urea, and 83.0% water, and the additive was formulated with 1.0% urea, 0.1% ammonium sulfate, and 0.25% phosphorus. In situ dry matter digestibility(DMD) was determined using the nylon bag technique with four cows equipped with ruminal fistulas. Cows were fed with ensiled sugarcane supplemented with 1 kg of commercial concentrate. 5 g of ground sample for each sugarcane treatment were weighted in nylon bags and incubated for 4, 8, 12, 24, 48, and 72 h in a completely randomized design with six replicates. The DMD(%) was higher(P<0.05) for SCS+ for all incubation times when compared with SCS. There were no differences in ruminal p H between the treatments for all the incubation times. The data suggested that the sugarcane silage with bacterial inoculum and additive could be an alternative for providing forage for ruminants during the season of low growth and quality grass. | José A Reyes-Gutiérrez Oziel D Montaez-Valdez Ramón Rodríguez-Macias Mario Ruíz-López Eduardo Salcedo-Pérez Cándido E Guerra-Medina | 2015 | Journal of Integrative Agriculture2015，14，3： | 3 |
| 4 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 5 | Is mechanical bowel preparation mandatory for elective colon surgery? A prospective randomized study显示文摘 | Ram E Sherman Y Weil R | | 0，，03： | 2 |
| 6 | Is mechanical bowel preparation man- datory for elective colon surgery 显示文摘 | Ram E Sherman Y Weil R | 2005 | Arch Surg2005，140，3： | 1 |
| 7 | Expression and importance of matrix metalloproteinase 2 and 9 ( MMP - 2 and - 9 ) in human trophoblast invasion显示文摘 | Staun - Ram E S Goldam D Gabarin | 2004 | Reprod Biol Endocrinol2004，2，： | 1 |
| 8 | Patterns of peroxidative ethane emission from submerged rice seedlings indicate that damage from reactive oxygen species takes place during submergence and is not necessarily a post-anoxic phenomenon显示文摘 | Santosa I E Ram P C Boamfa E I | 2007 | Planta2007，226，1： | 1 |
| 9 | Self-aligned graphene field-effect transistors with poly- ethyleneimine doped source/drain access regions 显示文摘 | MOVVA H C P RAM M E CORBET C M | 2012 | Applied Physics Letters2012，101，18： | 1 |
| 10 | Is mechanical bowel preparation mandatory for elective colon surgery? A prospective randomized study显示文摘 | Ram E Sherman Y Weil R | 2005 | Arch Surg2005，140，3： | 1 |
| 11 | Inventory control under gamma demand and random demand显示文摘 | John E Tyworth Ram Ganeshan | 1996 | Journal of Business Logistics1996，17，1： | 1 |
| 12 | Dynamic aspects of alcoholic fermentation of rice seedlings in response to anoxia and to complete submergence: Relationship to submergence tolerance 显示文摘 | Boamfa E I Ram P C Jackson M B | 2003 | Annals of Botany2003，91，： | 1 |
| 13 | Mechanisms of bacterial resistance to chromium compounds显示文摘 | Ramírez-Díaz MI Díaz-Pérez C Vargas E | 2008 | Biometals2008，21，3： | 1 |
| 14 | Bioactive phenolics andantioxidant propensity of flavedo extracts of Mauritian citrusfruits: Potential prophylactic ingredients for functional foodsapplication显示文摘 | Ramful D Bahorun T Bourdon E | 2010 | Toxicology2010，278，1： | 1 |
| 15 | Polyphenol composition,vitamin C content and antioxidant capacity of Mauritian citrus fruitpulps显示文摘 | Ramful D Tamus E Aruoma 0 I | 2011 | Food Research International2011，44，7： | 1 |
| 16 | Antivirals for management of herpes zoster including ophthalmicus: a systematic review of high-quality randomized controlled trials 显示文摘 | McDonald E M de Kock J Ram F S | 2012 | Antivir Ther2012，17，2： | 1 |
| 17 | Fly ash for soil amelioration:a review on the influence of ash blend ing with inorganic and organic amendments显示文摘 | RAM L C MASTO R E | 2014 | Earth-Science Reviews2014，128，1： | 1 |
| 18 | Judicial valuation of dissenting share- holder interests显示文摘 | Rams E M | 1975 | The Appraisal Journal1975，43，1： | 1 |
| 19 | Origin and basipetal transport of the IAA reponsible for rooting of carnation cuttings显示文摘 | Garrido G Ramón Guerrero J Angel Cano E Acosta M Sánchez-Bravo J | 2002 | Physiologia Plantarum2002，114，2： | 1 |
| 20 | Drug-induced life-threa-tening potassium disturbances detected by a pharmacovigilanceprogram from laboratory signals显示文摘 | Ramírez E Rossignoli T Campos AJ | 2013 | Eur J Clin Pharmacol2013，69，1： | 1 |
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