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| 1 | Incretins and selective renal sodium-glucose co-transporter 2 inhibitors in hypertension and coronary heart disease显示文摘Hyperglycemia is associated with an increased risk of cardiovascular disease,and the consequences ofintensive therapy may depend on the mechanism of the anti-diabetic agent(s)used to achieve a tight control.In animal models,stable analogues of glucagon-like peptide-1(GLP-1)were able to reduce body weight and blood pressure and also had favorable effects on ischemia following coronary reperfusion.In a similar way,dipeptidyl peptidase IV(DPPIV)showed to have favorable effects in animal models of ischemia/reperfusion.This could be due to the fact that DPPIV inhibitors were able to prevent the breakdown of GLP-1 and glucose-dependent insulinotropic polypeptide,but they also decreased the degradation of several vasoactive peptides.Preclinical data for GLP-1,its derivatives and inhibitors of the DPPIV enzyme degradation suggests that these agents may be able to,besides controlling glycaemia,induce cardio-protective and vasodilator effects.Notwithstanding the many favorable cardiovascular effects of GLP-1/incretins reported in different studies,many questions remain unanswered due the limited number of studies in human beings that aim to examine the effects of GLP-1 on cardiovascular endpoints.For this reason,long-term trials searching for positive cardiovascular effects are now in process,such as the CAROLINA and CARMELINA trials,which are supported by small pilot studies performed in humans(and many more animal studies)with incretin-based therapies.On the other hand,selective renal sodium-glucose co-transporter 2 inhibitors were also evaluated in the prevention of cardiovascular outcomes in type 2 diabetes.However,it is quite early to draw conclusions,since data on cardiovascular outcomes and cardiovascular death are limited and long-term studies are still ongoing.In this review,we will analyze the mechanisms underlying the cardiovascular effects of incretins and,at the same time,we will present a critical position about the real value of these compounds in the cardiovascular system and its protection. | Ramiro A Sanchez Hugo Sanabria Cecilia de los Santos Agustin J Ramirez | 2015 | World Journal of Diabetes2015，6，11： | 5 |
| 2 | Combustion optimisation of biomass residue pellets for domestic heating with a mural boiler显示文摘 | GONZALEZ J F MGONZALEZ-GARCIA C RAMIRO A | 2004 | Biomass and Bioenergy2004，27，： | 1 |
| 3 | A study on the glycaemie balance in streptozotocin-diabetic rats treated with an aqueous extract of Ficus carica (fig tree) leaves显示文摘 | Perez C Dominguez E Ramiro J M | 1996 | Phyto- ther Res1996，10，： | 1 |
| 4 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 5 | Pyrolysis gasification of agricultural residues by carbon dioxide in the presence of different additives:influence of variables显示文摘 | Encinar J M Beltran F J Ramiro A | 1998 | Fuel Processing Technology1998，55，3： | 1 |
| 6 | Cadmium(Ⅱ)and zinc(Ⅱ)adsorption by the aquatic moss Fontinalis antipyretica:effect of temperature,pH and water hardness显示文摘 | Rosana Pardo Rui R Boaventur | 2004 | Water Research2004，38，： | 1 |
| 7 | Efficacy of conventional synthetic disease-modifying antirheumatic drugs, glucocorticoids and tofacitinib: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis显示文摘 | Ganjoux-Viala C Nam J Ramiro S | 2014 | Ann Rheum Dis2014，73，3： | 1 |
| 8 | Pyrolysis-gasification of agricultural residues by carbon dioxide in the presence of different additives: influence of variables显示文摘 | ENCINAR J M BELTRAN F J RAMIRO A | 1998 | Fuel Processing Technology1998，55，： | 1 |
| 9 | Efficacy of conventional synthetic disease-modifying antirheumatic drugs,glucocorticoids and tofacitinib:a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis显示文摘 | Gaujoux-Viala C Nam J Ramiro S | 2014 | Ann Rheum Dis2014，73，3： | 1 |
| 10 | basal ganglia haematornas in severely head injured patients: clinieoradiologieal analysis of 37 cases显示文摘 | Gregorio R B Ramiro D L Juan J R | 2001 | J neurosurg2001，94，： | 1 |
| 11 | Removal of Cd( Ⅱ ) , Zn ( Ⅱ ) and Pb ( Ⅱ ) from aqueous solutions by brown marine macro algae: kinetic modeling显示文摘 | Olga M M F Ramiro J E M Cristina M | 2008 | Journal of Hazardous Materials2008，153，： | 1 |
| 12 | Do networks solve collective action problems: credibility, search and collaboration显示文摘 | Scholz J T Ramiro B Brad K | 2008 | The Journal of Politics2008，70，2： | 1 |
| 13 | Pyrolysis of two agricultural residues:Olive and grape bagasse:Influence of particle size and temperature显示文摘 | ENCINAR J M BELTRAN F J BERNALTE A RAMIRO A GONZALEZ J F | 1996 | Biomass Bioenergy1996，11，5： | 1 |
| 14 | A high-density collection of EMS-induced mutations for TILLING in Landsberg erecta genetic background of Arabidopsis 显示文摘 | Martin B Ramiro M Martinez-Zapater J M | 2009 | BMC Plant Biol2009，9，： | 1 |
| 15 | Extradural spinal meningiomas with intrathoracic extension:report of two cases显示文摘 | Martinez R Ramiro J Montero C | 1988 | J Neurosurg Sci1988，32，： | 1 |
| 16 | Pyrolysis/gasification of Agricultural Residues by Carbon Dioxide in the Presence of Different Additives:Influence of Variables显示文摘 | Encinar J M Beltrán F J Ramiro A | 1998 | Fuel Processing Technology1998，55，3： | 1 |
| 17 | Ependymal reaction afterexperimental spinal cord injury 显示文摘 | Vaquero J Ramiro MJ Oya S | 1981 | Acta Neurochir ( Wien )1981，55，34： | 1 |
| 18 | Weather data and energy balance of a hybrid photovoltaic-wind system with hydrogen storage 显示文摘 | M Calder6n A J Calder6n A Ramiro | 2010 | International Journal of Hydrogen Energy2010，，35： | 1 |
| 19 | Pyrolysis/gasification of agricultural residues by carbon dioxide in the presence of different additives:Influence of variables显示文摘 | ENCINAR J M BELTRáN F J RAMIRO A | 1998 | Fuel Processing Technology1998，55，3： | 1 |
| 20 | Pyrolysisgasification of agricultural residues by carbon dioxide in the presence of different additives:influence of variables显示文摘 | Encinar J M Beltran F J Ramiro A | 1998 | Fuel Processing Technology1998，55，： | 1 |
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