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| 1 | Laparoscopic common bile duct exploration with primary closure is safe for management of choledocholithiasis in elderly patients显示文摘Background:Laparoscopic common bile duct exploration(LCBDE)is one of the minimally invasive options for choledocholithiasis.Primary closure of the common bile duct(CBD)upon completion of laparoscopic choledochotomy is safe in selected patients.The present study aimed to evaluate the feasibility and safety of primary closure of CBD after LCBDE in patients aged 70 years or older.Methods:A total of 116 patients(51 males and 65 females)who suffered from choledocholithiasis and underwent primary closure of the CBD(without T-tube drainage)after LCBDE from January 2003 to December 2017 were recruited.They were classified into two groups according to age:group A(≥70 years,n=56),and group B(<70 years,n=60).The preoperative characteristics,intraoperative details,and postoperative outcomes of the two groups were evaluated.Results:The mean operative time was 172.02 min for group A and 169.92 min for group B(P=0.853).The mean hospital stay was 7.40 days for group A and 5.38 days for group B(P<0.001).Bile leakage occurred in two patients in group A and one in group B(3.57%vs 1.67%,P=0.952).There were no significant differences in the rates of postoperative complications and mortality between the two groups.At median follow-up time of 60 months,stone recurrence was detected in one patient in group A and two in group B(1.79%vs 3.33%,P=1.000).Stenosis of CBD was not observed in group A and slight stenosis in one patient in group B(0 vs 1.67%,P=1.000).Conclusion:Primary closure of the CBD upon completion of laparoscopic choledochotomy is safe and feasible in elderly patients≥70 years old. | Xiang Wu Ze-Jian Huang Jin-Yi Zhong Yi-Hong Ran Ming-Lei Ma Hong-Wei Zhang | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，6： | 30 |
| 2 | Multicenter case-control study of the risk factors for ulcerative colitis in China显示文摘AIM:To evaluate potential risk factors in the development of ulcerative colitis(UC) in China.METHODS:A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China.The UC cases were collected from 17 hospitals in China from April 2007 to April 2010.Uniform questionnaires were designed to investigate risk factors including smoking,appendectomy,stress,socio-economic conditions,nonsteroidal antiinflammatory drugs(NSAIDs),oral contraceptives,diet,breastfeeding,infections and family sanitary conditions.Group comparisons by each factor were done using simple logistic regression analysis.Conditional logistic regression was used for multivariate analysis.RESULTS:By univariate analysis,the variables predictive of UC included feeling stress,light and heavy alcoholic drinking,spicy food,sugar consumption and infectious diarrhea,while heavy tea intake and tap water consumption were protective against UC.On multivariate analysis,the protective factor for UC was tap water consumption [odds ratios(OR) = 0.424,95%CI:0.302-0.594,P < 0.001];while the potential risk factors for UC were heavy sugar consumption(OR = 1.632,95%CI:1.156-2.305,P < 0.001),spicy food(light intake:OR = 3.329,95%CI:2.282-4.857,P < 0.001;heavy intake:OR = 3.979,95%CI:2.700-5.863,P < 0.001),and often feeling stress(OR = 1.981,95%CI:1.447-2.711,P < 0.001).Other factors,such as smoking habit,appendectomy,breastfeeding,a history of measles,rural or urban residence,education,oral contraceptives,and NSAID use have not been found to have a significant association with the development of UC in the present study.CONCLUSION:Our study showed tap water consumption was a protective factor for UC,while spicy food,heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population. | Yu-Fang Wang Qin Ou-yang Bing Xia Li-Na Liu Fang Gu Kai-Fang Zhou Qiao Mei Rui-Hua Shi Zhi-Hua Ran Xiao-Di Wang Pin-Jin Hu Kai-Chun Wu Xin-Guang Liu Ying-Lei Miao Ying Han Xiao-Ping Wu Guo-Bing He Jie Zhong Guan-Jian Liu | 2013 | World Journal of Gastroenterology2013，19，11： | 24 |
| 3 | Asymptomatic patients of chronic obstructive pulmonary disease in China显示文摘背景长期的妨碍的肺的疾病(COPD ) 让可变自然历史和并非所有个人跟随一样的功课。这研究试图在 China.Methods 从基于人口的调查识别无征状的 COPD 病人的流行和特征多级式的簇采样策略从七不同省 / 城市在一张人口被使用。所有居民(超过 40 岁) 与一张标准化问询表被会见, spirometry.Post-bronchodilator 在 1 秒(FEV1 ) 强迫了吐气的体积 /forced 不到 70% 的重要能力(FVC ) 被定义为 COPD 的诊断标准。屏蔽的所有 COPD 病人根据长期的呼吸症状的存在或缺席被划分成征兆的组和无征状的组。Socio 人口统计,个人和暴露变量被收集,在从 25 627 采样与 COPD 被诊断的 1668 个病人之中的 analyzed.Results 使遭到,(35.3%) 589 是无征状的。年龄,性别,身体团索引(BMI ) ,农村、城市的分布,吸烟习惯和教育层次在二个组是类似的。64.7% 无征状的病人的一个总数没有 comorbidities。心血管的疾病和肺癌症比无征状的 group.Asymptomatic COPD 组多半是更少在厨房,呼吸疾病的家庭历史和周期性的童年咳嗽里与差的通风介绍的在征兆的 COPD 病人之中是更普通的。无征状的 COPD 病人有的显著地更高的 FEV1 (73.1% 对 61.0%) , FVC (91.9% 对 82.0%) ,和 FEV1/FVC (62.9%vs.58.7%) 的更高的比率(所有 P < 0.001 ) 比征兆的组。更无征状的病人是 underdiagnosed (91.9%vs.54.3% , P < 0.001 ) 比征兆的 patients.Conclusions,这大基于人口的调查在中国证实了无征状的 COPD 病人的高流行。屏蔽测试的呼吸量测定法的更多的使用可能对 COPD 的早察觉重要。 | LU Ming YAO Wan-zhen ZHONG Nan-shan ZHOU Yu-min WANG Chen CHEN Ping KANG Jian HUANG Shao-guang CHEN Bao-yuan WANG Chang-zheng NI Dian-tao WANG Xiao-ping WANG Da-li LIU Sheng-ming Lv Jia-chun SHEN Ning DING Yan-ling RAN Pi-xin | 2010 | Chinese Medical Journal2010，，12： | 17 |
| 4 | SHRIMP zircon U-Pb dating for gabbro from the Tiding ophiolite in Tibet显示文摘 | WANG Ran XIA Bin ZHOU Guoqing ZHANG Yuquan YANG Zhiqing LI Wenqian WEI Dongliang ZHONG Lifeng XU Lifeng | 2006 | Chinese Science Bulletin2006，51，14： | 14 |
| 5 | Carcinogenic potential of duodenal reflux juice from patients with long-standing postgastrectomy显示文摘AIM To determine, whether study on thecarcinogenic potential of reflux juice frompatients with remote gastrectomy could clarifythe inherent relationship between duodenalreflux and gastric stump cancer.METHODS A total of 37 reflux juice samples(13 Billroth T, 24 Billroth Ⅱ ) were employed inthe present study. A two- stage transformationassay using BALB/c 3T3 cells was carried out totest the initiating or promoting activity of thesesamples.RESULTS Two of 18 (11.1%) reflux samplesexerted initiating activities, whereas 9/19(47.4%) samples enhanced the MNNG-initiafingcell transformation, suggesting the duodenalreflux juice might more frequently possess thetumor-promoter activity (P = 0. 029). In addition,there was no difference in initiating activities ofthe samples irrespective of surgical procedures(P=0.488), while Billroth Ⅱ samples exhibitedstronger tumor-promoter activity than Billroth Ⅰsamples (P = 0.027). Furthermore, the promoteractivities were well correlated with thehistological changes of the stomas (rs = 0.625,P = 0.004), but neither their cytotoxicities norinitiating activities had this correlation( Probabilities were 0.523 and 0.085,respectively).CONCLUSION The duodenal reflux juice frompatients with remote postgastrectomy did havecarcinogenic potential, and suggested thattumor-promoting activity should principallyaccount for the high incidence of gastric cancerin gastrectomy patients. In contrast, it isdifficult to explain the high stump-cancerincidence with the 'N-nitroso compounds'theory-a popular theory for the intact stomachcarcinogenesis, and it seemed to be justified tofocus chemoprevention of this cancer on thetumor-promoting potential of reflux juice. | Zhe Fu Ma~1 Zhong Yu Wang~1 Jun Ran Zhang~2 Peng Gong~1 Hai Long Chen~1 ~1Departrnent of General Surgery,First Hospital,Dalian Medical University,Dalian 116011,China ~2Department of Radiation Oncology,Massachusetts General Hospital and Harvard Medical School,Charlestown,MA 02129,USADr.Zhe Fu Ma graduated from Shanxi Medical College in 1993,nowPh.D.,M.D.in Department of Surgery,Dalian Medical University,majoring gastroenteric cancer,having 4 papers published.Correspondence to:Dr.Zhe Fu Ma.Department of General Surgery,First Hospital,Dalian Medical University,Dalian 116011,China Tel.0086-411-4720334 | 2001 | World Journal of Gastroenterology2001，7，3： | 9 |
| 6 | Geochemistry and Sr-Nd isotope characteristics of tonalites in Zêtang,Tibet:New evidence for intra-Tethyan subduction显示文摘Tonalites from the island arc rock assemblage in the Zêtang segment of the Yarlung Zangbo suture zone were analyzed for major,trace elements (including REE) and Sr-Nd isotope. The experimental data demonstrate that the tonalites have the adakite-like characteristics,including high SiO2 (58%―63%),Al2O3 (18.4%―22.4%),Sr (810×10 6―940×10 6),Sr/Y (77―106),low HREE (Y=9×10 6―11×10 6,Yb= 1×10 6―1.3×10 6),with LREE enrichment and faint Eu positive anomaly. ISr (0.70421―0.70487) is rela-tively low whereas 143Nd/144Nd (0.512896―0.512929) and εNd(t) values (+6.7―+7.3) are high. These fea-tures suggest that Zêtang tonalites were formed by the partial melting of subducted oceanic crust,with involvement of a small amount of oceanic sediments. The identification of Zêtang adakites,derived from slab melting,presents new evidence for the intra-Tethyan subduction and the previous sugges-tion about the existence of intra-oceanic island arc within Tethys. | WEI DongLiang XIA Bin ZHOU GuoQing YAN Jun WANG Ran ZHONG LiFeng | 2007 | Science China Earth Sciences2007，50，6： | 9 |
| 7 | Self-powered nanofiber-based screen-print triboelectric sensors for respiratory monitoring显示文摘科学、商业的进展将高要求放为便携电子学。然而,便携电子学的电源供应, breathability,和大量生产仍然有需要被克服的许多挑战。在这研究,一个自我动力的基于 nanofiber 的摩擦电传感器(SNTS ) 被批规模制造技术用 electrospinning 制作并且为经由呼吸监视监视的健康打印屏幕。典型地,一个拱门结构的 SNTS 被 nanofiber 膜和一个 Ag nanoparticle 电极装配。nanofibers 的堆积和 Ag nanoparticles 的传导性的网络越过整个设备保证一条煤气的隧道。当时, SNTS 的煤气的渗透象 6.16 mm/s 一样高,它有压到优势的优点与由密封演员组电影组成的通常使用的便携设备相比。由于 nanofiber 膜的柔软,不管它是否被弄弯,扭曲,或合拢, SNTS 显示出优秀电子输出性能。优异性质 SNTS 的皮友好,自我力量,和批制造例如 breathability,在保健监视和多功能的聪明的系统为他们的申请提供巨大的潜力。 | Ran Cao diaona Wang Shuyu Zhao Wei Yang Zuqing Yuan Yingying Yin Xinyu Du Nian-Wu Li Xiuling Zhang Xiuyan Li Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，7： | 8 |
| 8 | Anti-corruption, government subsidies, and investment efficiency显示文摘The problem of corruption in socio-economic development has long been a focus of academics and practitioners. To address this concern in China, the 18th National Congress of the Communist Party of China instituted a new anti-corruption policy. In this paper, we examine the impact of this recently enacted anti-corruption policy on the investment efficiency of subsidized enter- prises from the perspective of government subsidies. We conclude that govern- ment subsidies have a significant positive impact on the overinvestment behavior of enterprises and that the anti-corruption work done by the govern- ment has effectively restrained the excessive investment behavior of government-subsidized enterprises. Further, we find that the anti-corruption policy is more effective in restricting overinvestment in subsidized stateowned enterprises than in non-state-owned enterprises. We examine the impact of the anti-corruption policy on excessive investment caused by government subsidies and enrich the body of research related to investment efficiency.We also provide empirical support for further research on the anti-corruption policy at the macro-market and micro-enterprise levels. The findings highlight the need to establish new cooperation between governmentand enterprises, to rationalize the distribution of administrative resources, and to promote the sustained and healthy development of the national economy. | Huili Zhang Ran An Qinlin Zhong | 2019 | China Journal of Accounting Research2019，，1： | 7 |
| 9 | DNA vaccine encoding Der p2 allergen down-regulates STAT6 expression in mouse model of allergen-induced allergic airway inflammation显示文摘Background Activation of signal transducer and activator of transcription 6 (STAT6 ) plays a critical role in the late phase of Th2-dependent allergy induction. STAT6 is essential to Th2 cell differentiation, recruitment, and effector function. Our previous study confirmed that DNA vaccination inhibited STAT6 expression of spleen cells induced by allergen. In the present study, we determined whether DNA vaccine encoding Dermatophagoides pteronyssinus group 2 (Der p2 ) could down-regulate the expression and activation of STAT6 in lung tissue from asthmatic mice. Methods After DNA vaccine immunization, BALB/c mice were sensitized by intraperitoneal injection and challenged by intranasal instillation of rDer p2. The levels of the cytokines IL-4 and IL-13 in BAL fluid were measured by enzyme-linked immunosorbent assay. The lung tissue was assessed by immunohistochemical staining with anti-STAT6. The protein expression of STAT6 was determined by Western blot. The activation of STAT6 binding ability was analyzed with electrophoretic mobility shift assay. Results DNA vaccine encoding Der p2 allergen effectively decreased the levels of IL-4 and IL-13 in the asthmatic mice. Histological evidence and Western blot showed that the expression of STAT6 in the DNA treated mice was markedly attenuated. STAT6 binding to specific DNA motif in lung tissue from the gene vaccinated mice was inhibited. Conclusion DNA vaccine encoding Der p2 prevents allergic pulmonary inflammation probably by inhibiting the STAT6 signaling pathway in mice with Der p2 allergen-induced allergic airway inflammation. | QIU Jing LI Guo-ping LIU Zhi-gang RAN Pei-xing ZHONG Nan-shan | 2006 | Chinese Medical Journal2006，，3： | 6 |
| 10 | Advances in lung cancer screening and early detection显示文摘Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health worldwide.Two randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer screening.However,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation exposure.This review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related issues.Second,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is presented.Third,current explorations of strategies for suspected malignancy are summarized.Overall,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer. | Caichen Li Huiting Wang Yu Jiang Wenhai Fu Xiwen Liu Ran Zhong Bo Cheng Feng Zhu Yang Xiang Jianxing He Wenhua Liang | 2022 | Cancer Biology & Medicine2022，19，5： | 6 |
| 11 | USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity显示文摘Cyclic GMP-AMP synthase(cGAS)is an essential sensor of cytosolic DNA and critically mediates innate immune responses and autoimmunity.Modulating the activity and stability of cGAS provides potential strategies for treating viral or autoimmune diseases.Here,we report that ubiquitin-specific protease 29(USP29)deubiquitinates and stabilizes cGAS and promotes cellular antiviral responses and autoimmunity.Knockdown or knockout of USP29 severely impairs Herpes simplex virus 1(HSV-1)-or cytosolic DNA-induced expression of type I interferons(IFNs)and proinflammatory cytokines.Consistently,Usp29m/m mice produce decreased type I IFNs and proinflammatory cytokines after HSV-1 infection and are hypersensitive to HSV-1 infection compared to the wild-type littermates.In addition,genetic ablation of USP29 in Trex1−/−mice eliminated the detectable pathological and molecular autoimmune phenotypes.Mechanistically,USP29 constitutively interacts with cGAS,deconjugates K48-linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection.Reconstitution of cGAS into Usp29−/−cells fully rescues type I IFN induction and cellular antiviral responses after HSV-1 infection.Our findings thus reveal a critical role of USP29 in the innate antiviral responses against DNA viruses and autoimmune diseases and provide insight into the regulation of cGAS. | Qiang Zhang Zhen Tang Ran An Liya Ye Bo Zhong | 2020 | Cell Research2020，30，10： | 5 |
| 12 | Functional assembly of root-associated microbial consortia improves nutrient efficiency and yield in soybean显示文摘Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated microbes or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that rootassociated microbes are critical influencers of host plant growth and nutrient acquisition. Three synthetic communities(SynComs) were constructed based on functional screening of 1,893 microbial strains isolated from root-associated compartments of soybean plants. Functional assemblage of SynComs promoted significant plant growth and nutrient acquisition under both N/P nutrient deficiency and sufficiency conditions.Field trials further revealed that application of SynComs stably and significantly promoted plant growth, facilitated N and P acquisition, and subsequently increased soybean yield. Among the tested communities, SynCom1 exhibited the greatest promotion effect, with yield increases of up to 36.1% observed in two field sites. Further RNA-seq implied that SynCom application systemically regulates N and P signaling networks at the transcriptional level, which leads to increased representation of important growth pathways, especially those related to auxin responses. Overall,this study details a promising strategy for constructing SynComs based on functional screening,which are capable of enhancing nutrient acquisition and crop yield through the activities of beneficial root-associated microbes. | Cunhu Wang Yanjun Li Mingjia Li Kefei Zhang Wenjing Ma Lei Zheng Hanyu Xu Baofeng Cui Ran Liu Yongqing Yang Yongjia Zhong Hong Liao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 5 |
| 13 | Factors influencing the natural regeneration of arrow bamboo in giant panda habitat of the north Minshan Mountains,southwestern China显示文摘To determine the effects of eco-factors on the regeneration of arrow bamboo in giant panda habitat,a field study was conducted in the Baozuo and Gonggangling Nature Reserves,Sichuan Province,China.A total of 183 quadrats(10 m×10 m) and 717 small quadrats(1 m×1 m) were investigated within the study site.Bamboo seedling density was used as an indicator of natural regeneration.Twelve factors were measured,which included topography and forest factors(elevation,slope aspect,slope degree,slope position,canopy cover,and shrub cover) and microhabitat factors(upper vegetation cover,herb cover,litter layer cover,moss cover,moss thickness,and dead bamboo density).A One-Way ANOVA was used to analyze the effects of topography and forest factors on seedling density,and a GLM(Generalized Linear Model) procedure was performed to examine the relationship between seedling density and microhabitat factors.The results indicated that elevation and canopy cover had highly significant effects on seedling density:bamboo seedling density was highest and showed the best regeneration at middle elevations(2800-3000 m) and under medium to medium-high canopy cover.Moss thickness,moss cover,and dead bamboo density were the most important microhabitat factors influencing the natural regeneration of bamboo:seedling density increased with increasing moss cover and moss thickness and decreased with increasing dead bamboo density.We propose that removal of dead bamboo and controlling grazing activities may accelerate the process of bamboo regeneration. | LI Bo ZHANG Man ZHONG Xue MOERMOND Timothy RAN JiangHong YANG XuYu | 2013 | Chinese Science Bulletin2013，58，17： | 4 |
| 14 | Experimental and modeling study of NO emission under high CO_2 concentration显示文摘An experimental and numerical study of the NOx formation and reduction process in a designed coal combustion furnace under both traditional air atmosphere and O2/CO2 atmosphere was conducted, in an attempt to explore the chemistry mechanism of the experimentally observed NOx suppression under high CO2 concentration atmospheres. A simplified ‘chemically oriented’ approach, computational fluid dynamics (CFD)-chemical kinetics modeling method, was validated and used to model the experimental process. The high CO2 concentration’s chemical effect on NO reduction has been studied, and the differences in NOx reaction behaviors between O2/CO2 atmosphere and air atmosphere were analyzed by detailed chemical kinetic model. On the basis of investigations through elementary chemical reactions, it can be concluded that high CO2 concentration plays an important role on NOx conversion process during oxy-fuel combustion. Moreover, the dominant reaction steps and the most important reactions for NO conversion under different atmospheres were discussed. Under O2/CO2 atmosphere, the main active sequence for NO reaction includes: NO→N→N2, and the main active path for NO reaction under air atmosphere is through N2→N→NO. | ZHAO Ran, LIU Hao, HU Han, ZHONG XiaoJiao, WANG ZiJian, XU ZhiYing & QIU JianRong State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, Wuhan, 430074, China | 2010 | Science China(Technological Sciences)2010，53，12： | 4 |
| 15 | Innovative Applications of Patient Experienee Big Data in Modern Hospital Management Improve Healthcare Quality显示文摘It is important for modern hospital management to strengthen medical humanistic care and build a harmonious doctor-patient relationship.Innovative applications of the big data resources of patient experience in modern hospital management facilitate hospital management to realize real-time supervision,dynamic management and s&entitle decision-making based on patients experiences.It is helping the transformation of hospital management from an administrator^perspective to a patients perspective,and from experience-driven to data-driven.The technological innovations in hospital management based on patient experience data can assist the optimization and continuous improvement of healthcare quality,therefore help to increase patient satisfaction to the medical services. | Xu Ran Feng Zhou Ming Zhong Yang Liu Jun Zhang | 2020 | Chinese Medical Sciences Journal2020，35，4： | 4 |
| 16 | Investigation on mechanical exhaust of cabin fire in large-space building显示文摘A calculation model for mechanical exhaust rate in large-space building in the case of cabin fire is proposed through theoretical analysis. Full-scale hot smoke tests are then performed to study the cabin fire spreading to large-space building at dif- ferent air change rates (ACH). The result indicates that under the standard pre- scribed ACH, the effective air heights in the large spaces are respectively 6, 4 and 2 m in the case of cabin fires of 0.34, 0.67 and 1 MW. Numerical experiment has been conducted using self-developing two-zone model. The smoke control effi- ciency is compared by varying the large space’s air change rate in the case of cabin fires ranging from 0.25 to 4 MW. The calculation results show that the air change rates are respectively 3, 6, 10 and 10 ACH when the smoke layer is kept above 5 m, indicating that the centralized exhaust rates far exceed the standard prescribed value. To address this problem, a set of subsidiary distributed mechanical exhaust installing in the cabin with high fire loads is proposed. The simulation shows that both from the safety and economy point of view, the adoption of subsidiary dis- tributed cabin exhaust design may effectively reduce the demand of designed air change rate for large-space building. | SHI CongLing ZHONG MaoHua HUO Ran | 2008 | Science China(Technological Sciences)2008，51，1： | 3 |
| 17 | Ultra-robust triboelectric nanogenerator for harvesting rotary mechanical energy显示文摘 | Xinyu Du Nianwu Li Yuebo Liu Jiaona Wang Zuqing Yuan Yingying Yin Ran Cao Shuyu Zhao Bin Wang Zhong Lin Wang Congju Li | 2018 | Nano Research2018，11，5： | 2 |
| 18 | Standard Protocol Items for Clinical Trials with Traditional Chinese Medicine 2018: Recommendations, Explanation and Elaboration(SPIRIT-TCM Extension 2018)显示文摘Traditional Chinese Medicine(TCM) is one of the oldest systems of medicine. More and more attention has been paid to TCM application, but the variable quality of clinical trials with TCM impedes its widespread acceptance. The Standard Protocol Items: Recommendations for Interventional Trials(SPIRIT) 2013 Statement has established guidelines for designing clinical trials to ensure that the trial results are accurate and reliable. However, there are difficulties when applying SPIRIT 2013 Statement to trials with TCM, due to the unique theory and the characteristic of TCM intervention. An Extension to the original SPIRIT was developed to ensure the quality of trial design with TCM. As Chinese herbal formulae, acupuncture and moxibustion are common and representative interventions in TCM practice, the executive working group determined that the SPIRIT-TCM Extension focus on these three interventions. Extension was developed through initiation, 3 rounds of Delphi consensus survey, and finalizing expert meeting. Seven items from the SPIRIT 2013 Statement were modified, namely, 'title', 'background and rationale', 'objectives', 'eligibility criteria', 'interventions', 'outcomes', and 'data collection methods'. The Extension includes the introduction of the concept of TCM pattern and 3 major TCM interventions, with examples and explanations. The SPIRIT-TCM Extension 2018 provides suggestion for investigators in designing high quality TCM clinical trials. It is expected that wide dissemination and application of this extension ensure continuous improvement of TCM trial quality throughout the world. | DAI Liang CHENG Chung-wah TIAN Ran ZHONG Linda LD LI You-ping LYU Ai-ping CHAN An-wen SHANG Hong-cai BIAN Zhao-xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，1： | 2 |
| 19 | Accelerated regeneration of the skeletal muscle in RNF13-knockout mice is mediated by macrophage-secreted IL-4/IL-6显示文摘(RNF13 ) 戒指手指蛋白质 13 是报导在癌症开发,肌肉房间生长,和 neuronal 开发的规定机能上地重要的最新识别的 E3 ligase。在这研究,在导致 cardiotoxin 的骨胳的肌肉新生的 RNF13 的功能用 RNF13 大美人老鼠被调查。RNF13 -/- 老鼠带着野类型的老鼠由加速的卫星房间 proliferationcompared 展出了提高的肌肉 regenerationcharacterized。RNF13 的表达式显著地在肌肉损坏的早阶段在巨噬细胞而非在野类型的鼠标的卫星房间被导致。这结果显示煽动性的房间在调停 RNF13 的卫星房间功能是重要的。在骨胳的肌肉的 cytokine 层次进一步被分析并且证明 RNF13 -/- 老鼠比野类型的老鼠生产了各种各样的 cytokines 的更大的数量。在这些之中, IL-4 和 IL-6 层次显著地在 RNF13 -/- 老鼠增加了。加速的肌肉新生显型被与堵住抗体在 RNF13 -/- 老鼠禁止 IL-4/IL-6 行动废除。这些结果显示那 RNF13 缺乏在卫星房间壁龛上经由效果支持骨胳的肌肉新生由 IL-4 和 IL-6 调停了。 | Jiao Meng Xiaoting Zou Rimao Wu Ran Zhong Dahai Zhu Yong Zhang | 2014 | Protein & Cell2014，5，3： | 2 |
| 20 | Factor V Leiden and thrombosis in patients with inflammatory bowel disease (IBD): A meta-analysis显示文摘 | Ming Zhong Xian Wen Dong Qing Zheng Jin Lu Tong Zhi Hua Ran | 2011 | Thrombosis Research2011，，5： | 2 |
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