| 1 | 复发性自然流产妇女血中膜联蛋白A5水平降低及膜联蛋白A5抗凝活性抵抗显示文摘Objective: We investigated whether levels of annexin A5,evidence for resistance to annexin A5 activity, and levels antiannexin A5 antibodies might be altered in women with a history of recurrent spontaneous pregnancy losses. Study design: These annexin A5 parameters were assayed in 70 nonpregnant women with a history of ≥3 recurrent spontaneous pregnancy losses (cases) and 50 women without adverse pregnancy history (control subjects). Results: Cases had significantly lower plasma annexin A5 levels than control subjects (median, 4.7 ng/mL [range, 0.3-40.4 ng/mL] vs 6.7 ng/mL [range, 0.7-56.0]; P = .01), significantly reduced anticoagulant ratios (188%[range, 119%-279%] vs 238%[range, 159%-286%]; P < .0001), and reduced binding of annexin A5 to phospholipid (6.3 ng/aliquot phospholipid [range, 1.5-16.4 ng/aliquot phospholipid] vs 9.7 ng/aliquot phospholipid (range, 3.5-17.0 ng/aliquot phospholipid]; P = .0002). There were no significant differences in anti-annexin A5 antibody levels. Conclusion: Reduction of annexin A5 and interference with its anticoagulant and binding activities are associated significantly with a history of recurrent spontaneous pregnancy losses. These data support the concept of a significant role for annexin A5 in the maintenance of pregnancy. | Rand J.H. Arslan A.A. 李奎 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，4： | 1 |
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