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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | One-year results of butterfly laser epithelial keratomileusis 显示文摘 | VINCIGUERRA P CAMESASCA F I RANDAZZO A | 2003 | J Refract Surg2003，19，2： | 1 |
| 3 | Axinellis A and B: New praline-containing antiproliferative cyclopeptides from the vanuatu sponge Axinella carteri显示文摘 | RANDAZZO A PIAZ F D ORRU S | 1998 | Eur J Org Chem1998，11，6： | 1 |
| 4 | A Brgl null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes显示文摘 | Bultman S Gebuhr T Yee D La Mantia C Nicholson J Gilliam A Randazzo F Metzg | | 0，，06： | 1 |
| 5 | Pharmacological management of night vision disturbances after refractive surgery results of a randomized clinical trial 显示文摘 | Randazzo A Nizzola F Rossetti L | 2005 | J Cataract Refract Surg2005，31，： | 1 |
| 6 | Polyphasiccharacterization of bacterial community in fresh cut salads显示文摘 | RANDAZZO C L SCIF6 G O OMASELLI F T | 2009 | International Journal of Food Microbiology2009，128，3： | 1 |
| 7 | Classification and description of dolomitic fabrics of rocks from the Floridan aquifer显示文摘 | Randazzo A F Zachos L G | 1984 | Sedimentary Geology1984，37，： | 1 |
| 8 | Polyphasic characterization of bacterial community in fresh cut salads显示文摘 | RANDAZZO C L SCIFG O TOMASELLI F | 2009 | International Journal of Food Microbiology2009，128，3： | 1 |
| 9 | Laparoscopic resection of large GIST of the stomach: is it preferable in elderly patients? A case report显示文摘 | La Greca G Randazzo V Barbagallo F | 2008 | Chir Ital2008，60，1： | 1 |
| 10 | Polyphasic characterization of bacterial community in fresh cut salads显示文摘 | Randazzo C L ScifòG O Tomaselli F | 2009 | International Journal of Food Microbiology2009，128，3： | 1 |
| 11 | Polyphasic characteriza-tion of bacterialcommunity in fresh cut salads显示文摘 | RANDAZZO CL SCIFO GO TOMASELLI F | 2009 | Int J Food Microbiol2009，128，： | 1 |
| 12 | Polyphasie characterization of bacterial community in fresh cut salads显示文摘 | RANDAZZO C L SCIFO G O TOMASELLI F | 2009 | Interna- tional Journal of Food Microbiology2009，128，3： | 1 |
| 13 | Characterization of Asxl I,a murine homolog of Additional sex combs,and analy- sis of the Asx- like gene family显示文摘 | Fisher CL Randazzo F Humphries RK | 2006 | Gene2006，369，： | 1 |
| 14 | Arf GTPase-activating proteins and their potential role in cell migration and invasion显示文摘 | Campa F Randazzo P A | 2008 | Cell Adhesion & Migration2008，2，4： | 1 |
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