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| 1 | Augmenting peripheral nerve regeneration using stem cells: A review of current opinion显示文摘Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell(SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration. | Neil G Fairbairn Amanda M Meppelink Joanna Ng-Glazier Mark A Randolph Jonathan M Winograd | 2015 | World Journal of Stem Cells2015，7，1： | 12 |
| 2 | A dual positional specific lipoxygenase functions in the generation of flavor compounds during climacteric ripening of apple显示文摘Lipoxygenase(LOX)is an important contributor to the formation of aroma-active C6 aldehydes in apple(Malus×domestica)fruit upon tissue disruption but little is known about its role in autonomously produced aroma volatiles from intact tissue.We explored the expression of 22 putative LOX genes in apple throughout ripening,but only six LOXs were expressed in a ripening-dependent manner.Recombinant LOX1:Md:1a,LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b proteins showed 13/9-LOX,9-LOX,13/9-LOX and 13-LOX activity with linoleic acid,respectively.While products of LOX1:Md:1c and LOX2:Md:2b were S-configured,LOX1:Md:1a and LOX2:Md:2a formed 13(R)-hydroperoxides as major products.Site-directed mutagenesis of Gly567 to an alanine converted the dual positional specific LOX1:Md:1a to an enzyme with a high specificity for 9(S)-hydroperoxide formation.The high expression level of the corresponding MdLOX1a gene in stored apple fruit,the genetic association with a quantitative trait locus for fruit ester and the remarkable agreement in regio-and stereoselectivity of the LOX1:Md:1a reaction with the overall LOX activity found in mature apple fruits,suggest a major physiological function of LOX1:Md:1a during climacteric ripening of apples.While LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b may contribute to aldehyde production in immature fruit upon cell disruption our results furnish additional evidence that LOX1:Md:1a probably regulates the availability of precursors for ester production in intact fruit tissue. | Doreen Schiller Carolina Contreras Jörg Vogt Frank Dunemann Bruno G Defilippi Randolph Beaudry Wilfried Schwab | 2015 | Horticulture Research2015，2，1： | 6 |
| 3 | Chemical and cultural control of the sunflower moth in Texas显示文摘 | Teetes G L Randolph N M | 1969 | J Econ Entomol1969，62，： | 1 |
| 4 | Cochrane review:Corti-costeroids for the prevention and treatment of post-extubation stridor in neonates,children and adults显示文摘 | Markovitz B Randolph A Khemani R G | | 0，，： | 1 |
| 5 | Rationality of load transfer approach for pile analysis显示文摘 | WEI D G RANDOLPH M F | 1998 | Computers and Geotechics1998，34，2： | 1 |
| 6 | Clinical practice guideline: improving voice outcomes after thyroid surgery显示文摘 | CHANDRASEKHAR S S RANDOLPH G W SEIDMAN M D | 2013 | Otolaryngol Head Neck Surg2013，148，6： | 1 |
| 7 | Total thyroidectomy is associated with increased risk of complications for low- and high- volume surgeons显示文摘 | Hauch A AI-Qurayshi Z Randolph G | 2014 | Ann Surg Oncol2014，21，12： | 1 |
| 8 | The thyroid and parathyroid glands:CT and MRI imaging and correlation with pathology and clinical findings显示文摘 | Weber AL Randolph G Aksoy FG | 2000 | Radiol Clin North Am2000，38，5： | 1 |
| 9 | Assessing Relationships Among Strategic Types,Distinctive Marketing Competencies and Organizational Performance显示文摘 | Arch G W Daniel P S Randolph J T | 1999 | Journal of Business research1999，，45： | 1 |
| 10 | Efficacy of betaine as a carcass modifier in finishing pigs fed normal and reduced energy diets显示文摘 | Cromwell G L Lindemann M D Randolph J R | 1999 | Journal of Animal Science1999，77，1： | 1 |
| 11 | One-dimensional analysis of soil plugs in pipe piles显示文摘 | RANDOLPH M F LEONG E C HOULSBY G T | 1991 | Geotechnique1991，41，4： | 1 |
| 12 | Monotonic lateral loading of Piles in calcareous sand显示文摘 | Dyson G J RandolPh M F | | 0，，04： | 1 |
| 13 | Hibernation, spring emergence, and pupation habits of the sunflower moth, Homoeosoma electellum显示文摘 | Teetes G L Randolph N M | 1970 | Ann Entomol Soc Am1970，63，5： | 1 |
| 14 | The thyroid and parathyroid glands, CT and MR imaging and correlation with pathology and clinical findings显示文摘 | Weber AL Randolph G Aksoy FG | 2000 | Radial Clin North Am2000，38，： | 1 |
| 15 | Corticosteroids for the prevention of reintubation and postextubation stridor in pediatric patients: a meta-analysis显示文摘 | Markovitz B P Randolph A G | 2002 | Pediatr Crit Care Med2002，3，3： | 1 |
| 16 | The thyroid andparathyroid glands CT and MR imaging and correlationwith pathology and clinical findings显示文摘 | Weber AL Randolph G Aks oy FG | 2000 | Radiol Clin NorthAM2000，38，5： | 1 |
| 17 | Dendritic-cell trafficking to lymph nodes through lymphatic vessels显示文摘 | Randolph G J Angeli V Swartz M A | 2005 | Nat Rev Immunol2005，5，8： | 1 |
| 18 | A biomechanical analysis of an engineered cell2 scaffold implant for cartilage repair显示文摘 | Peretti G M Randolph M A Zaporojan V | 2001 | Ann Plast Surg2001，46，5： | 1 |
| 19 | The prog- nostic significance of nodal metastases from papillary thy- roid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the pres- ence of extranodal extension显示文摘 | Randolph G W Duh Q Y Heller K S | 2012 | Thyroid2012，22，11： | 1 |
| 20 | Friedlander approach for the incorporation of 6-bromoquinoline into novel chelating ligands显示文摘 | Hu Y Z Zhang G Randolph P T | 2003 | Org lett2003，5，13： | 1 |
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